FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

Dai, Weixing; Meng, Xiangjun; Mo, Shaobo; Xiang, Wenqiang; Xu, Ye; Zhang, Long; Wang, Renjie; Li, Qingguo; Cai, Guoxiang

doi:10.1186/s12964-019-0502-8

Cited by 22 publications

(13 citation statements)

References 34 publications

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“…7). In other tissues, FOXE1 operates as a tumor suppressor [93][94][95]. Recent studies have shown that FOXE1 regulates cell proliferation and migration by activating the Wnt/βcatenin pathway in thyroid carcinoma cells [96,97].…”

Section: Discussionmentioning

confidence: 99%

Transcriptional landscape of the embryonic chicken Müllerian duct

et al. 2020

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Background Müllerian ducts are paired embryonic tubes that give rise to the female reproductive tract in vertebrates. Many disorders of female reproduction can be attributed to anomalies of Müllerian duct development. However, the molecular genetics of Müllerian duct formation is poorly understood and most disorders of duct development have unknown etiology. In this study, we describe for the first time the transcriptional landscape of the embryonic Müllerian duct, using the chicken embryo as a model system. RNA sequencing was conducted at 1 day intervals during duct formation to identify developmentally-regulated genes, validated by in situ hybridization. Results This analysis detected hundreds of genes specifically up-regulated during duct morphogenesis. Gene ontology and pathway analysis revealed enrichment for developmental pathways associated with cell adhesion, cell migration and proliferation, ERK and WNT signaling, and, interestingly, axonal guidance. The latter included factors linked to neuronal cell migration or axonal outgrowth, such as Ephrin B2, netrin receptor, SLIT1 and class A semaphorins. A number of transcriptional modules were identified that centred around key hub genes specifying matrix-associated signaling factors; SPOCK1, HTRA3 and ADGRD1. Several novel regulators of the WNT and TFG-β signaling pathway were identified in Müllerian ducts, including APCDD1 and DKK1, BMP3 and TGFBI. A number of novel transcription factors were also identified, including OSR1, FOXE1, PRICKLE1, TSHZ3 and SMARCA2. In addition, over 100 long non-coding RNAs (lncRNAs) were expressed during duct formation. Conclusions This study provides a rich resource of new candidate genes for Müllerian duct development and its disorders. It also sheds light on the molecular pathways engaged during tubulogenesis, a fundamental process in embryonic development.

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Section: Discussionmentioning

confidence: 99%

Transcriptional landscape of the embryonic chicken Müllerian duct

et al. 2020

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“…This is of great interest since FOXE1 is a regulator of gene expression and essential for thyroid development and differentiation. FOXE1 is predominantly express in the thyroid but expression has also be found in colon, lung, and orofacial tissue [97][98][99]. FOXE1 has not been observed to play a role in fibrosis but a number of FOX member have shown to be involved in fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Characterization of Burn Eschar Pericytes

Evdokiou

Kanisicak

Gierek

et al. 2020

JCM

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Pericytes are cells that reside adjacent to microvasculature and regulate vascular function. Pericytes gained great interest in the field of wound healing and regenerative medicine due to their multipotential fate and ability to enhance angiogenesis. In burn wounds, scarring and scar contractures are the major pathologic feature and cause loss of mobility. The present study investigated the influence of burn wound environment on pericytes during wound healing. Pericytes isolated from normal skin and tangentially excised burn eschar tissues were analyzed for differences in gene and protein expression using RNA-seq., immunocytochemistry, and ELISA analyses. RNA-seq identified 443 differentially expressed genes between normal- and burn eschar-derived pericytes. Whereas, comparing normal skin pericytes to normal skin fibroblasts identified 1021 distinct genes and comparing burn eschar pericytes to normal skin fibroblasts identified 2449 differential genes. Altogether, forkhead box E1 (FOXE1), a transcription factor, was identified as a unique marker for skin pericytes. Interestingly, FOXE1 levels were significantly elevated in burn eschar pericytes compared to normal. Additionally, burn wound pericytes showed increased expression of profibrotic genes periostin, fibronectin, and endosialin and a gain in contractile function, suggesting a contribution to scarring and fibrosis. Our findings suggest that the burn wound environment promotes pericytes to differentiate into a myofibroblast-like phenotype promoting scar formation and fibrosis.

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“…FOXE1, one of the forkhead box (FOX) transcription factor family members, was found to be a prognostic marker for CRC patients. Knockdown of FOXE1 in CRC cell lines HT29 and SW480 by shRNA remarkably increased cell proliferation, colony formation and promoted glucose consumption, as well as lactate production through the FOXE1/HK2 axis, indicating that targeting FOXE1 could be a promising therapeutic option for CRC [261].…”

Section: Glycolysis Inhibitorsmentioning

confidence: 99%

Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy

Nenkov

Gaßler

et al. 2021

IJMS

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Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark of cancer, is closely related to the initiation and progression of carcinomas, including CRC. Accumulating evidence shows that activation of oncogenic pathways and loss of tumor suppressor genes regulate the metabolic reprogramming that is mainly involved in glycolysis, glutaminolysis, one-carbon metabolism and lipid metabolism. The abnormal metabolic program provides tumor cells with abundant energy, nutrients and redox requirements to support their malignant growth and metastasis, which is accompanied by impaired metabolic flexibility in the tumor microenvironment (TME) and dysbiosis of the gut microbiota. The metabolic crosstalk between the tumor cells, the components of the TME and the intestinal microbiota further facilitates CRC cell proliferation, invasion and metastasis and leads to therapy resistance. Hence, to target the dysregulated tumor metabolism, the TME and the gut microbiota, novel preventive and therapeutic applications are required. In this review, the dysregulation of metabolic programs, molecular pathways, the TME and the intestinal microbiota in CRC is addressed. Possible therapeutic strategies, including metabolic inhibition and immune therapy in CRC, as well as modulation of the aberrant intestinal microbiota, are discussed.

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FOXE1 represses cell proliferation and Warburg effect by inhibiting HK2 in colorectal cancer

Cited by 22 publications

References 34 publications

Transcriptional landscape of the embryonic chicken Müllerian duct

Transcriptional landscape of the embryonic chicken Müllerian duct

Characterization of Burn Eschar Pericytes

Metabolic Reprogramming of Colorectal Cancer Cells and the Microenvironment: Implication for Therapy

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