FOXD2‐AS1 correlates with the malignant status and regulates cell proliferation, migration, and invasion in cutaneous melanoma

Abstract

Long noncoding RNA (lncRNA) FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been shown to be dysregulated in several types of human cancer. However, the role of FOXD2‐AS1 in cutaneous melanoma was still unclear. In our study, FOXD2‐AS1 expression has been found to be upregulated in cutaneous melanoma tissue specimens and cell lines compared with that in normal tissue specimens and normal human epidermal melanocyte, respectively. Furthermore, high expression of FOXD2‐AS1 was obviously correlated with deep Breslow thickness, present ulceration, high Clark level and distant metastasis in cutaneous melanoma patients. However, there were no statistical associations between FOXD2‐AS1 expression and cutaneous melanoma patients’ disease‐free survival and overall survival. The results of loss‐of‐function study showed that inhibition of FOXD2‐AS1 suppresses cutaneous melanoma cell proliferation, migration and invasion through regulating phospho‐Akt expression. In conclusion, FOXD2‐AS1 is associated with clinical progression in cutaneous melanoma patients, and functions as oncogenic lncRNA in cutaneous melanoma cells.

RETRACTED: Long Noncoding RNA FOXD2-AS1 Promotes the Malignancy of Cervical Cancer by Sponging MicroRNA-760 and Upregulating Hepatoma-Derived Growth Factor

“…The overall survival and progression-free survival of bladder cancer patients with high FOXD2-AS1 expression is shorter than that of bladder cancer patients with low FOXD2-AS1 expression (Su et al, 2018). Overexpressed FOXD2-AS1 is observed in multiple other types of human cancer, including hepatocellular carcinoma (Chang et al, 2018;Zhao et al, 2018;Xu et al, 2019), glioma (Ni et al, 2019), thyroid cancer Jiang et al, 2019;Liu et al, 2019), cutaneous melanoma (Ren et al, 2019), colorectal cancer (Zhu et al, 2018), esophageal squamous cell carcinoma (Bao et al, 2018), and non-small cell lung cancer (Rong et al, 2017). Nevertheless, FOXD2-AS1 expression status in cervical cancer has been unknown and warrants investigation.…”

“…In hepatocellular carcinoma, silencing of FOXD2-AS1 expression suppresses cell proliferation, colony formation, metastasis, and epithelial-mesenchymal transition; induces cell cycle arrest at the G0-G1 transition; and decreases tumor growth and metastasis in vivo (Chang et al, 2018;Zhao et al, 2018;Xu et al, 2019). FOXD2-AS1 also exerts oncogenic actions on carcinogenesis including progression of bladder cancer (Su et al, 2018), glioma (Ni et al, 2019), cutaneous melanoma (Ren et al, 2019), colorectal cancer (Zhu (Bao et al, 2018), and non-small cell lung cancer (Rong et al, 2017). Nevertheless, no studies have focused on specific functional roles of FOXD2-AS1 in the malignant characteristics of cervical cancer.…”

“…FOXD2-AS1 is dysregulated in multiple types of human cancer, and its dysregulation is involved in the modulation of various tumor-associated biological processes (Rong et al, 2017;Bao et al, 2018;Chang et al, 2018;Su et al, 2018;Zhang et al, 2018;Zhao et al, 2018;Zhu et al, 2018;Jiang et al, 2019;Liu et al, 2019;Ni et al, 2019;Ren et al, 2019;Xu et al, 2019). To the best of our knowledge, however, the expression status and detailed roles of FOXD2-AS1 in cervical cancer are still unknown.…”

LncRNA FOXD2-AS1 induces chondrocyte proliferation through sponging miR-27a-3p in osteoarthritis

“…For example, Rong et al showed that FOXD2-AS1 promoted non-small cell lung cancer progression via Wnt/b-catenin signaling [15]. Ren et al revealed that FOXD2-AS1 expression was correlated with the malignant status in cutaneous melanoma and could regulate cell proliferation, migration and invasion ability [16]. Zhu et al suggested that FOXD2-AS1 contributed to colorectal cancer proliferation through interaction with miR-185-5p [17].…”

Upregulation of long non‐coding RNA FOXD2‐AS1 promotes progression and predicts poor prognosis in tongue squamous cell carcinoma

“…In recent studies, lncRNAs are found playing an increasing important role in tumor progression 7‐9 , however, the understanding of lncRNAs in tumor is still poor. LncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2‐AS1) has been reported upregulated in several caners and modulates their malignant biological behaviors 10‐12 . Nonetheless, the role of FOXD2‐AS1 in TSCC progression still remains unknown.…”