Foxc1 promotes the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis via PI3K/AKT signalling pathway

Yu, Zhaohui; Xu, Hua; Wang, Hailin; Wang, Youhua

doi:10.1016/j.tice.2018.05.011

Cited by 17 publications

(9 citation statements)

References 26 publications

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“…POU domain-related TFs function in the cell cycle regulation of immunoglobulins and are involved in viral infection (16). Regulators in the FOX family are well-known regulators of cell proliferation, e.g., FOXC1 increases the proliferation of fibroblast-like synoviocytes in autoimmune diseases (17). In contrast, activities of the tumor suppressor protein p53, ETS-related proteins, and immune-related TFs (including STAT3, SMAD4, and macrophage migration inhibitory factor) were negatively correlated with the MRSS ( Figure 3A).…”

Section: (Supplemental Figures 3 and 4 And Supplementalmentioning

confidence: 99%

Regulator combinations identify systemic sclerosis patients with more severe disease

et al. 2020

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Section: (Supplemental Figures 3 and 4 And Supplementalmentioning

confidence: 99%

Regulator combinations identify systemic sclerosis patients with more severe disease

et al. 2020

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“…The present findings seem to be consistent with other research that found that FGFR is activated in the process of wound healing 25 . Intriguingly, published papers have established that foxc1 can promote the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis via the PI3K/AKT signalling pathway 35 .…”

Section: ■ Discussionmentioning

confidence: 99%

Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo

et al. 2019

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To explore the potential role and unclear molecular mechanisms of vaccarin in wound healing. Methods: Rats' skin excision model to study the effects of vaccarin on wound healing in vivo. Hematoxylin and eosin staining was performed to evaluate Histopathologic characteristics. Immunohistochemistry was employed to assess the effects of vaccarin in accelerating angiogenesis. Western blot was used to evaluate relative protein expressed levels. Results: Vaccarin could significantly promote wound healing and endothelial cells and fibroblasts proliferation in the wound site. Immunohistochemistry and Western blot studies showed that the nodal proteins and receptor (bFGFR) related to angiogenesis signaling pathway were activated, and the microvascular density in the wound site was markedly higher than that in the control group. Conclusions: The present study was the first to demonstrate that vaccarin is able to induce angiogenesis and accelerate wound healing in vivo by increasing expressions of p-Akt, pErk and p-bFGFR. This process is mediated by MAPK/ERK and PI3K/AKT signaling pathways.

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“…Mizoguchi et al. ( 59 ) identify seven different fibroblast surface protein phenotypes and classified them into three subsets according to the expression of podoplanin (PDPN) ( 60 , 61 ), cadherin-11 (CDH11) ( 46 , 62 ), THY1 (also known as CD90) ( 63 ) and CD34 ( 64 ) by integrating transcriptomic data. they found that different subsets of fibroblasts play different roles in joint inflammation and bone destruction.…”

Section: Scrna-seq Of Synovial Fibroblastsmentioning

confidence: 99%

New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis

Cheng

Wang

et al. 2021

Front. Immunol.

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Single-cell RNA sequencing (scRNA-seq) technology can analyze the transcriptome expression level of cells with high-throughput from the single cell level, fully show the heterogeneity of cells, and provide a new way for the study of multicellular biological heterogeneity. Synovitis is the pathological basis of rheumatoid arthritis (RA). Synovial fibroblasts (SFs) and synovial macrophages are the core target cells of RA, which results in the destruction of articular cartilage, as well as bone. Recent scRNA-seq technology has made breakthroughs in the differentiation and development of two types of synovial cells, identification of subsets, functional analysis, and new therapeutic targets, which will bring remarkable changes in RA treatment.

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Foxc1 promotes the proliferation of fibroblast-like synoviocytes in rheumatoid arthritis via PI3K/AKT signalling pathway

Cited by 17 publications

References 26 publications

Regulator combinations identify systemic sclerosis patients with more severe disease

Regulator combinations identify systemic sclerosis patients with more severe disease

Vaccarin hastens wound healing by promoting angiogenesis via activation of MAPK/ERK and PI3K/AKT signaling pathways in vivo

New Insights From Single-Cell Sequencing Data: Synovial Fibroblasts and Synovial Macrophages in Rheumatoid Arthritis

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