Fowl plague virus adapted to human epithelial tumor cells and human myeloblasts in vitro

Gerber, Andrea; Sauter, Christian; Lindenmann, Jean

doi:10.1007/bf01242544

Cited by 14 publications

(4 citation statements)

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“…The present report shows that an avian influenza A virus (TUR), after serial passages, caused acute lethal hepatitis in various mouse strains. This result was anticipated for the following reasons : a) Avian influenza viruses are reportedly easy to adapt to new host cells (8,9,17,26), b) classical fowl plague (strain Brescia) is known to produce peculiar histopathologieal changes in mouse liver (15), c) the intrinsic susceptibility of mouse liver cells for human influenza viruses has been revealed by earlier studies (21, 24). Nevertheless, reliable growth of myxoviruses in hepatic tissues has, to our knoMedge, not been previously described.…”

Section: Discussionmentioning

confidence: 63%

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A mouse hepatotropic variant of influenza virus

Haller

1975

Archives of Virology

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A hepatotropic variant of avian influenza virus A/Turkey/England 63 (Hav 1, Nav 3) was selected by serial passages in mouse liver. Adaptation to this organ was established after 13 in vivo passages and was found to improve during further passages as shown by increasing rates of replication in livers of ICR mice. The mutant virus finally selected was stable and differed from the original virus mainly in lethality upon intraperitoneal injection in mice, in its ability to grow to high titers in livers of susceptible animals and in plaque morphology in chick embryo fibroblasts. No differences were detected in hemagglutination inhibition and neutralization by standard mouse antisera. Pathogenicity for the liver was independent of the route of inoculation, included other laboratory animals sensitive to influenza virus and could be inhibited by amantadine. Fatal hepatitis in 50 per cent of susceptible mice by the intraperitoneal route required from 10 to 20 EID50-. Pathological changes consisted of severe necrosis of liver parenchyma accompanied by release of F antigen into the serum and were apparently due to virus replication in hepatic cells as evidenced by immunofluorescence. The main implications of this animal model for studies on experimental hepatitis and on myxovirus-host interactions in an organ not usually associated with influenza are discussed.

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Section: Discussionmentioning

confidence: 63%

“…To that purpose a strain of avian influenza virus, A/Turkey/England/63, scrologieally related to fowl plague (23) and showing a high adaptability to a number of tissues (8,9,17,26) was chosen. The present paper reports its successful adaptation to mouse liver.…”

Section: Introductionmentioning

confidence: 99%

A mouse hepatotropic variant of influenza virus

Haller

1975

Archives of Virology

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show abstract

“…Fowl plague virus (FPV; A/Turkey/England/63, Hav 1 Nav 3, Langham strain) has been adapted to leukemia cells as previously described [4],…”

Section: Virusmentioning

confidence: 99%

“…Myxovirus-infected tumor cells could very effectively protect animals from tumor challenge [6]. To use this myxovirus effect in the therapeutic strategy of acute myelogenous leukemia, an avian influenza A virus not pathogenic for man was adapted to human leukemic myeloblasts [4]. This virus re plicated well in the leukemia cells in vitro of many patients suffering from acute myelogenous leukemia [7].…”

Section: Introductionmentioning

confidence: 99%