Fowl adenovirus Group I as a causal agent of inclusion body hepatitis/hydropericardium syndrome (IBH/HPS) outbreak in brazilian broiler flocks

Mettifogo, Elena; Núñez, L; Parra, Silvana Hipatia Santander; Astolfi-Ferreira, Claudete S.; Ferreira, Antônio José Piantino

doi:10.1590/s0100-736x2014000800004

Cited by 14 publications

(7 citation statements)

References 30 publications

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“…The decreased weight gain and gross lesions observed in livers of birds seen in FAdV-11(MOR300315) inoculated SPF chickens were comparable to those obtained in other experiments [ 28 , 44 ] as well as in natural infections with FAdV-11 [ 5 , 6 , 33 , 42 , 48 – 50 ]. Poor weight gain was mainly attributed to malabsorption [ 42 , 48 , 49 ].…”

Section: Discussionsupporting

confidence: 86%

Pathogenicity of field strain of fowl aviadenovirus serotype 11 isolated from chickens with inclusion body hepatitis in Morocco

Abghour

Mouahid²,

Darkaoui³

et al. 2021

PLoS ONE

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Outbreaks of inclusion body hepatitis have emerged in Morocco since 2013 and has resulted in significant economic losses to poultry farms. Three isolates of the causative virus, Fowl adenonovirus (FAdV)were characterized from chickens with IBH, but their pathogenicity has never been investigated. In this work, the pathogenicity of an isolate FAdV 11 (MOR300315 strain) was evaluated by inoculating a group of 40 SPF chickens at 3 days of age by oral route. A group of 40 chicks injected with phosphate-buffered saline solution was used as a control group. The infected chickens showed decreased weight gain from 3dpi. Necropsy displayed pallor and enlargement in liver, swelling and slight hemorrhage in kidney and spleen at 6 dpi. Histopathological changes were mainly characterized by severe and extensive hepatic necrosis associated with the presence of basophilic intra-nuclear inclusion bodies within hepatocytes. The FAdV was reisolated in chicken embryo fibroblast cell culture from liver tissue homogenate of infected chicken from 3 to 6 dpi. Viral DNA was detected by PCR in liver, kidney, spleen and cloacal swabs from 3 to 13 dpi. Antibody response against inoculated FAdV was appeared from 9 dpi. These results confirmed that the FAdV 11 strain is pathogenic in chicken. This study is the first experimental infection of FAdV 11 in chicken in Morocco, which increase our understanding of its pathogenicity in chickens and indicate that preventive measures against FAdV infection in poultry farms should be implemented in Morocco.

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Section: Discussionsupporting

confidence: 86%

Pathogenicity of field strain of fowl aviadenovirus serotype 11 isolated from chickens with inclusion body hepatitis in Morocco

Abghour

Mouahid²,

Darkaoui³

et al. 2021

PLoS ONE

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“…There has been an increase in reports of HHS and IBH outbreaks from various regions in the last ten years, such as in Europe [41][42][43][44], Asia [45][46][47][48][49], Oceania [30], North America [50], South America [51,52], and Africa [53,54], indicating even geographical spread of FAdVs. As in most Asian countries, FAdV-induced outbreaks in poultry have been observed in South Korea for many years, and, to date, these outbreaks persist.…”

Section: Introductionmentioning

confidence: 99%

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

2021

Viruses

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Fowl adenoviruses (FAdVs) have long been recognized as critical viral pathogens within the poultry industry, associated with severe economic implications worldwide. This specific group of viruses is responsible for a broad spectrum of diseases in birds, and an increasing occurrence of outbreaks was observed in the last ten years. Since their first discovery forty years ago in South Korea, twelve antigenically distinct serotypes of fowl adenoviruses have been described. This comprehensive review covers the history of fowl adenovirus outbreaks in South Korea and updates the current epidemiological landscape of serotype diversity and replacement as well as challenges in developing effective broadly protective vaccines. In addition, transitions in the prevalence of dominant fowl adenovirus serotypes from 2007 to 2021, alongside the history of intervention strategies, are brought into focus. Finally, future aspects are also discussed.

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“…From IBH cases, predominantly strains belonging to species FAdV-D and FAdV-E have been isolated in different countries (Nakamura et al., 2011; Ojkić et al., 2008; Schachner et al., 2016; Zadravec et al., 2011, 2013). Pathogenic strains of FAdV-4 (from species FAdV-C) are responsible for HHS outbreaks (Li et al., 2016; Mase et al., 2009; Mettifogo et al., 2014), whereas GE is associated with FAdV-1 (species FAdV-A) infection (Domanska-Blicharz et al., 2011; Kecskeméti et al., 2012; Lim et al., 2012; Thanasut et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

An emerging new fowl adenovirus genotype

Kaján

Affranio

Bistyák

et al. 2019

Heliyon

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In this work, we examined the diversity of fowl adenovirus (FAdV) types occurring in Hungary. From diseased chicken flocks in Eastern Hungary, 29 FAdV strains were isolated between 2011 and 2015. We performed molecular typing of the isolates based on their partial hexon sequences. The results showed that representatives from every FAdV species from A to E are present in Hungary, but compared to the findings from our previous survey, a lower number of different FAdV types were detected. Inclusion body hepatitis was always associated with FAdV-2 or -8b, gizzard erosion was caused in almost every case by FAdV-1. Numerous strains belonging to species FAdV-B were found. The complete genome sequence of a candidate new genotype strain, showing the highest divergence from the reference FAdV-5, was determined using next generation sequencing. In order to provide results compatible with the serology-based type classification, multiple genomic regions, including the major antigenic determinants, of the new isolate (strain 40440-M/2015) were compared to their counterparts in the prototype FAdV-5 (strain 340) from species FAdV-B, at both nucleotide and amino acid sequence levels. In different comparative analyses, the two strains were always found to have larger divergence between each other than any two of the most closely related FAdV serotypes. This new emerging FAdV genotype is already present in Hungary and Austria, though its exact pathological role requires further investigations. The introduction of a novel FAdV (geno)type for the classification of these strains is further supported.

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Fowl adenovirus Group I as a causal agent of inclusion body hepatitis/hydropericardium syndrome (IBH/HPS) outbreak in brazilian broiler flocks

Cited by 14 publications

References 30 publications

Pathogenicity of field strain of fowl aviadenovirus serotype 11 isolated from chickens with inclusion body hepatitis in Morocco

Pathogenicity of field strain of fowl aviadenovirus serotype 11 isolated from chickens with inclusion body hepatitis in Morocco

Historical Investigation of Fowl Adenovirus Outbreaks in South Korea from 2007 to 2021: A Comprehensive Review

An emerging new fowl adenovirus genotype

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