Foveal threshold and photoreceptor integrity for prediction of visual acuity after intravitreal aflibercept on age-related macular degeneration

Abstract

PurposeTo determine whether baseline foveal threshold and photoreceptor integrity can predict best-corrected visual acuity (BCVA) at 12 months after intravitreal aflibercept (IVA) therapy in eyes with neovascular age-related macular degeneration (AMD).Patients and methodsWe evaluated 25 eyes of 25 patients with treatment-naïve neovascular AMD who received IVA once a month for 3 months, followed by once every 2 months for 8 months. BCVA, integrity of the external limiting membrane (ELM) or the ellipsoid zone (EZ) of the photoreceptors, and retinal sensitivity were determined before (baseline) and at 6 and 12 months after initial IVA. The average threshold foveal sensitivity and mean deviation within the central 10° were determined by Humphrey central 10-2 perimetry. Correlations between BCVA at 12 months and integrity of the ELM or EZ, foveal threshold, and mean deviation at each visit were determined.ResultsAt 12 months, BCVA improved significantly from 0.20±0.23 to 0.10±0.22 logMAR (logarithm of the minimum angle of resolution) units, and foveal threshold and mean deviation improved significantly from 29.0±5.1 and −3.38±3.10 dB to 32.6±3.2 and −1.64±2.10 dB, respectively (P=0.0009 and P=0.0021). At baseline, both foveal threshold and integrity of the ELM were significantly correlated with BCVA at 12 months (P=0.0428 and P=0.0275).ConclusionThese results indicate that both integrity of the ELM and foveal threshold at baseline can predict BCVA after treatment for neovascular AMD. There is a possibility that these parameters can predict the efficacy of IVA in each case.

Reliability of Subjective Assessment of Spectral-Domain OCT Pathologic Features by Multiple Raters in Retinal Vein Occlusion

“…However, some studies did not calculate or state interrater reliability, nor were OCT scans assessed by multiple observers. 34,35 Intraclass correlation is an alternative method for analyzing the agreement of interval-scaled parameters measured by multiple observers. Therefore, intraclass correlation was applied occasionally when more than 2 graders assessed the length of disrupted retinal boundaries on OCT cross sections.…”

Lamellar Macular Holes: The Role of Microperimetry in Functional Assessment

“…As the second step, we evaluated the integrity of the outer retinal layers, which represents a pathognomonic sign of visual acuity preservation. Several authors have described impaired visual recovery in patients affected by diabetic macular edema or exudative AMD when the IZ/EZ was damaged [16, 17]. Tractional LMHs showed integrity of the IZ/EZ line in 81.8% of the eyes; conversely, in degenerative LMH, IZ/EZ was present only in 14.3% of eyes ( p < 0.05).…”

Прогнозирование Возрастной Макулярной Дегенерации На Основании Определения Функциональной Активности Рецепторов Тромбоцитов

“…1,2 , Ковальчук К.В. 1,2,4 , Зяблицев С.В. 3 Проанализированы 9 факторных признаков и выявлено 5 значимых факторов риска, тесно связанных со стадией ВМД: активность пуриновых Р2Х-, А2А-рецепторов, ФАТ-рецепторов, а также α 2 -и β 2 -адренорецепторов.…”

“…Mogilevskyy 1,2 , Kh.V. Kovalchuk 1,2,4 , S.V. Ziablitsev 3 1 Shupyk National Medical Academy of Postgraduate Education of the Ministry of Health of Ukraine, Kyiv, Ukraine 2 Kyiv City Clinical Ophthalmological Hospital «Eye Microsurgery Centre», Kyiv, Ukraine 3 Bogomolets National Medical University of the Ministry of Health of Ukraine, Kyiv, Ukraine 4 Medical center "LAZER Plus", Lviv, Ukraine…”