Foveal Intraretinal Fluid Localization Affects the Visual Prognosis of Branch Retinal Vein Occlusion

Sasajima, Hirofumi; Zako, Masaru; Maeda, Rio; Murotani, Kenta; Ishida, Hideyuki; Ueta, Yoshiki

doi:10.3390/jcm11123540

Cited by 4 publications

(5 citation statements)

References 23 publications

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“…This con rms the assumption that other factors regarding macular dynamics and visual acuity prognosis could be much more valuable than CMT. Similar conclusions were stated by Scott et al [12], who underlined the fact that a weak connection between these two variables could be made, or Tah et al [13], who sustained the fact that many other factors will have an impact on BCVA independently of CMT and could dissipate the dependence of this correlation [13,14]. Nevertheless, our results were different regarding the BRVO group of cases, where a strong correlation was found between a CMT decrease and BCVA increase.…”

Section: Discussionsupporting

confidence: 87%

Macular dynamics and visual acuity prognosis in retinal vein occlusions—Ways to connect

Darabus

Pac

Roşca³

et al. 2023

Preprint

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Background The aim of this study was to establish possible connections between macular dynamics, various macular features and visual acuity prognosis among patients with retinal vein occlusions. Methods This study included 85 patients with central retinal vein occlusions (CRVO) and 26 with branch retinal vein occlusions (BRVO). We assessed macular features such as central macular thickness (CMT), foveal intraretinal hemorrhage (IRH), the presence and distribution of hyperreflective foci (HF), ellipsoid zone (EZ) disruption, inner retinal layer disorganization (DRIL), and posterior vitreous detachment (PVD), as well as their dynamics over one year of observation and their impact on final visual acuity prognosis, depending on the type of occlusion. Results Best corrected visual acuity (BCVA) evolution is statistically significant regarding groups of age and type of occlusion and insignificant regarding gender. The best response to intravitreal treatment, quantified as a decrease in CMT, was registered after the first intravitreal injection. Connecting a decrease in CMT with BCVA improvement, we did not register a statistically significant correlation in the CRVO group, only in BRVO cases. The study results show that complete PVD plays a significant positive role in decreasing CMT and BCVA improvement in cases of CRVO. Our study revealed that no matter the type of occlusion, the presence of foveal IRH will have a negative impact on the BCVA outcome. Statistically significant differences have been noted only for the evolution of visual acuity in non-ischemic CRVO cases, in correlation with the presence of EZ disruption. Outer retinal layer HF have proved to be predictive factors for poor visual acuity outcomes. Conclusions The most important non-imaging predicting factors regarding BCVA after retinal vein occlusions are age and baseline BCVA. CMT’s dynamics still establish a weak connection with visual acuity fluctuations. The presence of foveal IRH, outer retinal layer HF and foveal EZ disruption have a negative impact on visual acuity outcome.

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Section: Discussionsupporting

confidence: 87%

Macular dynamics and visual acuity prognosis in retinal vein occlusions—Ways to connect

Darabus

Pac

Roşca³

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…This confirmed the assumption that other factors regarding macular dynamics and visual acuity prognosis could be much more valuable than CMT. Scott et al [ 12 ] stated similar conclusions, which underlined the fact that a weak connection between these two variables could be made, and Tah et al [ 13 ] sustained the fact that many other factors will have an impact on BCVA independently of CMT and could dissipate the dependence of this correlation [ 13 , 14 ]. Nevertheless, our results were different regarding the BRVO group of cases, in which a strong correlation was found between a CMT decrease and a BCVA increase.…”

Section: Discussionmentioning

confidence: 95%

Macular dynamics and visual acuity prognosis in retinal vein occlusions - ways to connect

2023

rjo

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Background and Objectives: This study aimed to establish possible connections between macular dynamics, various macular features, and visual acuity prognosis among patients with retinal vein occlusions. Materials and Methods: This study included 85 patients with central retinal vein occlusions (CRVO) and 26 with branch retinal vein occlusions (BRVO). We assessed macular features such as central macular thickness (CMT), foveal intraretinal hemorrhage (IRH), the presence and distribution of hyperreflective foci (HF), ellipsoid zone (EZ) disruption, inner retinal layer disorganization (DRIL), and posterior vitreous detachment (PVD), as well as their dynamics over one year of observation and their impact on final visual acuity prognosis, depending on the type of occlusion. Results: Best corrected visual acuity (BCVA) evolution is statistically significant regarding groups of age and type of occlusion and insignificant regarding gender. The best response to intravitreal treatment, quantified as a decrease in CMT, was registered after the first intravitreal injection. Connecting a decrease in CMT with BCVA improvement, we did not register a statistically significant correlation in the CRVO group, only in BRVO cases. The study results showed that complete PVD plays a significant positive role in decreasing CMT and BCVA improvement in cases of CRVO. Our study revealed that no matter the type of occlusion, the presence of foveal IRH will have a negative impact on the BCVA outcome. Statistically significant differences have been noted only for the evolution of visual acuity in non-ischemic CRVO cases, in correlation with the presence of EZ disruption. Outer retinal layer HF has proved to be a predictive factor for poor visual acuity outcomes. Conclusions: The most important non-imaging predicting factors regarding BCVA after retinal vein occlusions are age and baseline BCVA. CMT’s dynamics still establish a weak connection with visual acuity fluctuations. The presence of foveal IRH, outer retinal layer HF, and foveal EZ disruption has a negative impact on visual acuity outcomes. Abbreviations: CRVO = central retinal vein occlusions, BRVO = branch retinal vein occlusions, CMT = central macular thickness, IRH = foveal intraretinal hemorrhage, HF = hyperreflective foci, EZ = ellipsoid zone disruption, DRIL = inner retinal layer disorganization, PVD = posterior vitreous detachment, BCVA = best corrected visual acuity, OCT = optical coherence tomography, BCVA Ti = best corrected visual acuity at first, BCVA Tf = best corrected visual acuity after one year, NR of IVI = number of intravitreal injections, SD = standard deviation, M = male, F = female, CMT Ti = central macular thickness at first, CMT T1 = central macular thickness after first injection, CMT T3 = central macular thickness after 3 injections, CMT Tf = central macular thickness after one year

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“…To date, studies have reported several factors affecting visual prognosis in branch retinal vein occlusion (BRVO) [1][2][3][4][5]. Younger patients [1][2][3][4] and a better baseline logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) [1][2][3]5] are good visual prognoses for BRVO.…”

Section: Introductionmentioning

confidence: 99%

“…Optical coherence tomography (OCT) findings have clarified factors affecting the visual prognosis for BRVO [3,[5][6][7]. Intraretinal fluid and subretinal fluid (SRF) in eyes with BRVO are often detected using OCT images [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Visual Prognostic Factors in Eyes with Subretinal Fluid Associated with Branch Retinal Vein Occlusion

Sasajima¹,

Zako²,

Murotani

et al. 2023

JCM

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We investigated whether foveal ellipsoid zone (EZ) status affects visual prognosis in eyes with subretinal fluid (SRF) associated with branch retinal vein occlusion (BRVO). We included 38 eyes retrospectively and classified those with or without a continuous EZ on the SRF of the central foveola on the vertical optical coherence tomography (OCT) image at the initial visit as intact (n = 26) and disruptive EZ (n = 12) groups, respectively. In addition, we classified the intact EZ eyes into clear (n = 15) and blurred (n = 11) EZ groups according to whether EZ on the SRF was observed distinctly or not. Multiple regression analyses showed that baseline EZ status significantly correlated (p = 0.0028) with the 12-months logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA), indicating that baseline intact EZ significantly improves visual prognosis. The 12-months logMAR BCVA of the intact EZ group was significantly better (p < 0.001) than that of the disruptive EZ group, and did not differ significantly between the clear and blurred EZ groups. Thus, baseline foveal EZ status on vertical OCT images can be a novel biomarker for visual prognosis in eyes with SRF associated with BRVO.

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Foveal Intraretinal Fluid Localization Affects the Visual Prognosis of Branch Retinal Vein Occlusion

Cited by 4 publications

References 23 publications

Macular dynamics and visual acuity prognosis in retinal vein occlusions—Ways to connect

Macular dynamics and visual acuity prognosis in retinal vein occlusions—Ways to connect

Macular dynamics and visual acuity prognosis in retinal vein occlusions - ways to connect

Visual Prognostic Factors in Eyes with Subretinal Fluid Associated with Branch Retinal Vein Occlusion

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