Foveal avascular zone analysis by optical coherence tomography angiography in patients with type 1 and 2 diabetes and without clinical signs of diabetic retinopathy

Oliverio, Giovanni William; Ceravolo, Ida; Bhatti, Ahsan; Trombetta, C. J.

doi:10.1007/s10792-020-01621-z

Cited by 29 publications

(31 citation statements)

References 46 publications

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“…e advances in optical coherence tomography (OCT) technology have contributed to improving our understanding of the pathophysiology and classification of diabetic macular edema and have enabled us to recognize structural biomarkers for a morphologic categorization of the disease that can influence treatment outcome [2,[5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent

Meduri

Oliverio

Trombetta

et al. 2021

Journal of Ophthalmology

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Purpose. To evaluate efficacy and safety of intravitreal dexamethasone 0.7 mg implant in treatment-naïve DME patients and to assess the utility of OCT structural biomarkers as predictors of functional response after treatment. Methods. Thirty-nine eyes of 39 diabetic patients with center involving DME were enrolled. Best-corrected visual acuity (BCVA) and SS-OCT (DRI SS-OCT Triton, Topcon, Japan) to evaluate central retinal thickness (CRT), serous retinal detachment (SRD), intraretinal cysts (IRC), number of hyper-reflective spots (HRS), integrity of the ellipsoid zone (EZ), disorganization of the inner retinal layers (DRIL), vitreomacular adhesion (VMA), vitreomacular traction (VMT), and posterior vitreous detachment (PVD) were evaluated at baseline and at 3, 6, and 12 months after treatment. Multiple logistic analysis was performed to evaluate the possible OCT biomarker as predictive factors for final visual acuity improvement at the end of treatment. Results. At 12 months after treatment, the mean BCVA improved from 51.6 ± 17.5 to 56.9 ± 17.3 ETDRS letters ( p = 0.03 ). Furthermore, there were statistically significant changes in CRT, IRC, HRS, and SRD. Nineteen patients presented a >10-letters improvement in BCVA; the presence of SRD at baseline was a predictor of good functional treatment response at 12 months (OR 2.1; 95% C.I. 1.2–4.9; p = 0.001 ) as well as the presence of EZ integrity preoperatively (OR 1.3; 95% C.I. 0.5–2.4; p = 0.001 ) and the absence of vitreoretinal interface alteration (OR 1.1; 95% C.I. 0.3–2.3; p = 0.02 ). No significant changes in the IOP and lens status were observed throughout the follow-up period. Conclusion. This study empathized the importance of structural biomarkers as predictors of favorable response and confirmed the efficacy and safety of intravitreal dexamethasone implant in treatment-naïve DME patients showing a better functional response in the presence of SRD integrity of EZ and absence of vitreoretinal alterations.

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Section: Introductionmentioning

confidence: 99%

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent

Meduri

Oliverio

Trombetta

et al. 2021

Journal of Ophthalmology

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“…Although FA is necessary for identification of the disease, this is a time-consuming, dye-dependent technique and does not allow users to examinate the deep capillary plexus. OCTA may be an effective alternative to the standard FA as it consents to the microvascular analysis of both superficial and deep capillary plexi and to monitoring of the vascular density changes without dye injection [24]. However, additional prospective studies are necessary to establish the role of OCTA, widefield color fundus photography, and AF to monitor disease activity and to determine the efficacy of new therapeutic approaches [25].…”

Section: Discussionmentioning

confidence: 99%

Multimodal Imaging in Susac Syndrome: A Case Report and Literature Review

Bagaglia

Passani

Oliverio

et al. 2021

IJERPH

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Susac syndrome (SS) is a rare microangiopathy that involves arterioles of the brain, retina, and cochlea. Diagnosis is extremely difficult because of the rarity of the disease and because the signs and symptoms often occur at different times. Multidisciplinary approaches and multimodal images are mandatory for diagnosis and prompt therapy. In this report, we describe a case of SS and the application of multimodal retinal imaging to evaluate the ophthalmologic changes and to confirm diagnosis. Early diagnosis and therapy based on the associations of steroids and immunosuppressants are necessary to limit the sequelae of the disease.

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“…The FAZ is highly sensitive to ischemia. Atrophic changes of macular capillaries might rst affect the shape and size of FAZ, which had been proved to have signi cant clinical application value in retinal vein occlusion and diabetic retinopathy 15,16,29 . However, few studies investigated the clinical value of FAZ in glaucoma, especially PACG.…”

Section: Discussionmentioning

confidence: 99%

“…The FAZ is highly susceptible to ischemia. Diabetic retinopathy and retinal vein occlusion can lead to the expansion of FAZ area 15,16 . Previous study reported that FAZ parameters in POAG had good diagnostic ability by using OCTA 17 .…”

Section: Introductionmentioning

confidence: 99%

Spatial Positional Relationship Between Macular Superficial Vessel Density and Ganglion Cell-Inner Plexiform Layer Thickness in Primary Angle Closure Glaucoma

Lin

Wang

et al. 2021

Preprint

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Purpose: To evaluate the spatial relationship between macular superficial vessel density (SVD) and macular ganglion cell-inner plexiform layer (GCIPL) thickness in primary angle-closure glaucoma (PACG), and to investigate diagnostic abilities of macular SVD and foveal avascular zone (FAZ) parameters.Methods: This was a cross-sectional study on 38 PACG patients (38 eyes) and 25 healthy subjects (25 eyes). Macular region was imaged using a 1050-nm-wavelength swept-source optical coherence tomography (OCT) angiography (OCTA) system (DRI OCT Triton, TOPCON). Vessel density of the macular region was quantified by ImageJ software. The peripapillary retinal nerve fiber layer (pRNFL) thicknesses and macular GCIPL thickness were obtained by swept-source OCT. Pearson correlation analysis was used to evaluate the spatial positional relationship between macular SVD and macular GCIPL thickness. At the same time, the correlation between macular SVD and pRNFL thickness was evaluated. Areas under the receiver operating characteristics curves (AUCs) of OCT, OCTA and FAZ measurement metrics were calculated to assess the diagnostic ability for glaucoma.Results: Macular GCIPL thickness had a moderate correlation with the macular SVD in the inferonasal sector (r = 0.426, P = 0.008). In addition, there was a strong correlation between inferonasal sector of macular vessel density and 5,6,7,8 clock-hour regions of the pRNFL thicknesses(all r>0.5). Inferoinferior sector of macular SVD and 6,7 clock-hour regions of pRNFL thicknesses also had strong correlation (all r>0.5).The AUCs of macular SVD ranged between 0.61 (superonasal sector) and 0.76 (inferoinferior sector).The FAZ circularity index showed the highest diagnostic power (AUC= 0.94;95% CI, 0.85-0.99), followed by superotemporal sector of macular GCIPL thicknesses (0.93;95% CI,0.83-0.98).Conclusions: Sector of macular SVD not only had a spatial positional correlation with corresponding macular GCIPL thickness, but also with clock-hour regional pRNFL thicknesses in PACG eyes. FAZ circulation index might be a useful diagnostic parameter.

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Foveal avascular zone analysis by optical coherence tomography angiography in patients with type 1 and 2 diabetes and without clinical signs of diabetic retinopathy

Cited by 29 publications

References 46 publications

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent

Optical Coherence Tomography Predictors of Favorable Functional Response in Naïve Diabetic Macular Edema Eyes Treated with Dexamethasone Implants as a First-Line Agent

Multimodal Imaging in Susac Syndrome: A Case Report and Literature Review

Spatial Positional Relationship Between Macular Superficial Vessel Density and Ganglion Cell-Inner Plexiform Layer Thickness in Primary Angle Closure Glaucoma

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