Fournier’s Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report

Mosayebi, Ziba; Omidian, Ali; Movahedian, A H; Kompani, Farzad; Hosseininodeh, Seyyed Saeed

doi:10.5812/ijp.4537

Cited by 10 publications

(21 citation statements)

References 12 publications

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“…Yoshino et al [6] described the case of an anal fistula in a patient with type 2 diabetes mellitus, resulting in an abscess of pararectal tissue complicated by Fournier gangrene. Mosayebi et al [7] described Fournier gangrene in a newborn with acute myeloid leukemia. Ishida et al [8] led a clinical case of the occurrence of Fournier gangrene in a patient who received chemotherapy for colon cancer.…”

Section: Epidemiological Situationmentioning

confidence: 99%

Fournier’s Gangrene: Literature Review and Clinical Cases

Chernyadyev¹,

et al. 2018

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Background: Fornier gangrene is an extremely rare disease of the genitals. This disease is a result of the urogenital tract, anorectal area, and genital skin infections, appearing usually in immunocompromised patients with diabetes, obesity, and malignant neoplasms. The basic treatment of Fournier gangrene includes an emergency surgical intervention combined with antibiotic therapy and detoxification. Methods: A review of recent papers comprising studies and reviews published in 2005–2016 was performed. The clinical cases were studied at the Department of Purulent Surgery Central Clinical Hospital No. 1, where 7 patients were diagnosed and treated. Results: The etiology, pathogenesis, clinical and laboratory presentation, diagnosis, treatment, and prognosis of Fournier gangrene are described in this article. The authors have described several clinical cases of patients with Fournier gangrene and with necrotic cellulitis and fasciomyositis of anterior abdominal wall, which is a manifestation of Fournier gangrene. Making allowance for the unfavorable epidemiological situation of syphilis in Russia, the increase in the incidence of complicated, atypical chancre, and therefore, the need for differentiation of Fournier gangrene with such manifestations of syphilis as necrotizing, esthiomenous chancre, indurative edema, the appropriate clinical examples are well explained in this article.

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Section: Epidemiological Situationmentioning

confidence: 99%

Fournier’s Gangrene: Literature Review and Clinical Cases

Chernyadyev¹,

et al. 2018

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“…Further assessment of eligibility, based on full-text papers, led to the exclusion of nineteen papers. Finally, 35 papers (6 case series and 29 case reports) involving a total of 44 patients were included in the final analysis ( Figure 1 ) [ 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Resultsmentioning

confidence: 99%

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

et al. 2021

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Patients suffering from hematological malignancies are at increased risk of Fournier’s gangrene (FG) due to immunosuppression caused by the disease itself or by disease-related treatments. A systematic review of PubMed, ISI Web of Knowledge, and Scopus databases was performed in June 2021. We included full papers that met the following criteria: original research, human studies, and describing clinical presentation, treatment, and outcomes of FG in patients with oncohematological diseases. We identified 35 papers published from 1983 to 2021 involving 44 patients (34 males, 8 females) aged between 4 days and 83 years. The most common malignant hematological disorders were acute myeloid leukemia (n = 21) and acute lymphocytic leukemia (n = 9). In 10 patients FG represented the first presentation of hematological malignancy. Scrotum (n= 27) and perineum (n = 11) were the sites most commonly involved. Pseudomonas aeruginosa (n = 21) and Escherichia coli (n = 6) were the most commonly isolated microorganisms. Surgery was performed in 39 patients. Vacuum-assisted closure and hyperbaric oxygen therapy were adopted in 4 and in 3 patients, respectively. Recovery was achieved in 30 patients. FG-related mortality was observed in 11 patients. FG should be carefully considered in patients with oncohematological diseases.

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“…One other case report of genital infection, without progression to necrosis, as the first sign of AML has been reported in the literature in a 51-year-old patient following perineal trauma. 14 His blood counts showed a normal total leukocyte count, but the differential was notable for 83% myeloblast predominance. A simple incision and drainage was performed.…”

Section: Discussionmentioning

confidence: 97%

Fournier’s gangrene as an initial manifestation of acute promyelocytic leukemia: A case report and review of the literature

Mostaghim

Dhanani

Ingalls

2019

SAGE Open Medical Case Reports

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Fournier’s gangrene is classically associated with diabetes mellitus and alcohol use disorder. While it is associated with chemotherapy, there are few case reports of Fournier’s gangrene as the initial presentation of acute myelogenous leukemia. A 38-year-old male presented with progressive scrotal swelling and hematochezia. Blood cell count showed depression of all cell lines without myeloblasts. He received broad-spectrum antibiotics and underwent surgical debridement once. Urgent bone marrow biopsy confirmed acute promyelocytic leukemia. The patient was started on chemotherapy. He was discharged without relapse of the infection. This is the fourth case of acute myelogenous leukemia presenting as Fournier’s gangrene in the literature and the only case to have survived. This brings forth a possible diagnostic consideration in patients without obvious predisposing risk factors for Fournier’s gangrene, particularly in those with pancytopenia. Coordination with surgical services as well as hematology/oncology specialists is imperative to survival of these dual diagnosis patients.

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Fournier’s Gangrene in a Neonate With Acute Myeloid Leukemia: A Case Report

Cited by 10 publications

References 12 publications

Fournier’s Gangrene: Literature Review and Clinical Cases

Fournier’s Gangrene: Literature Review and Clinical Cases

Fournier’s Gangrene in Patients with Oncohematological Diseases: A Systematic Review of Published Cases

Fournier’s gangrene as an initial manifestation of acute promyelocytic leukemia: A case report and review of the literature

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