Fourier transform surface-enhanced Raman scattering of single-layer nucleolipid Langmuir–Blodgett films on silver island film substrates

Wu, Sanxie; Huang, Jianguo; Li, Chun; Liang, Yingqiu

doi:10.1016/j.jcis.2003.10.004

Cited by 6 publications

(6 citation statements)

References 34 publications

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“…Table summarizes the peak positions in the SERS, Raman, and IR absorption spectra. Also the interpretation of the spectral peaks was done in Table taking into account the data of refs and . As is seen from Table there is reasonable correspondence among the SERS, Raman, and IR positions of the vibrational bands, while their relative intensities are different.…”

Section: Resultsmentioning

confidence: 88%

“…It is known that there are two mechanisms for the SERS effect: an electromagnetic enhancement mechanism and a chemical enhancement mechanism. ,– The first mechanism is a long-range effect that does not require molecule adsorption on the metal surface. The second mechanism requires the absorption of molecules.…”

Section: Resultsmentioning

confidence: 99%

“…Solid SERS active substrates are known to be stable for a long time. 11,12,25,26 In the present work a new method for SERS active substrate synthesis is proposed. The substrate is Ag nanoparticles synthesized by photo-or thermodecomposition of Langmuir-Blodgett layers of the silver salt of a fatty acid.…”

Section: Introductionmentioning

confidence: 99%

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New Surface-Enhanced Raman Scattering Active Substrate Fabricated by Use of the Langmuir−Blodgett Technique

et al. 2010

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A new method of fabrication of a substrate for surface-enhanced Raman scattering (SERS) is proposed. The substrate is a layer of Ag nanoparticles on a solid surface, where the nanoparticles are synthesized by photo- or thermodecomposition of Langmuir−Blodgett layers of the silver salt of a fatty acid. The number of Ag nanoparticles depends on the number and composition of the monolayers. The optical properties and morphology of the substrate were studied by ultraviolet−visible absorption spectroscopy, scanning electron microscopy, and atomic force microscopy. It was found that the localized surface plasmon resonance has a maximum extinction in the range of 470−480 nm. The SERS ability was tested by use of a Langmuir−Blodgett film of hydroxamic acid.

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Section: Resultsmentioning

confidence: 88%

Section: Resultsmentioning

confidence: 99%

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New Surface-Enhanced Raman Scattering Active Substrate Fabricated by Use of the Langmuir−Blodgett Technique

et al. 2010

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“…Moreover, there are no significant changes of characteristic peaks at 448 and 1362 cm −1 , respectively, belonging to the Al–O and NO 3 − vibrations, in the IR spectra of LDH after PNA loading, also indicating the noncovalent PNA loading. [ 26 ] For further experiments, PNA was labeled with fluorescent fluoresceine isothiocyanate (FITC) groups for subsequent characterization. Fluorescence emission spectrum of LDHs/PNA‐FITC in Figure 3d shows the emission wavelength of FITC group at 520 nm.…”

Section: Figurementioning

confidence: 99%

Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)‐Loaded Layered Double Hydroxides (LDH) Nanoplatform

et al. 2020

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Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest malignant tumors with extremely poor prognosis due to the later stage diagnosis when surgical resection is no longer applicable. Alternatively, the traditional gene therapy which drives pancreatic cancer cells into an inactive state and inhibiting the proliferation and metastasis, presents potentials to safely inhibit pancreatic cancer progression, but unfortunately has received limited success to date. Here, an efficient gene therapy of pancreatic cancer is shown via a peptide nucleic acid (PNA)‐loaded layered double hydroxides (LDHs) nanoplatform. Compared with the traditional DNA‐ or RNA‐based gene therapies, the gene therapy using PNA features great advantages in recognizing and hybridizing with the target mutant sequences to form PNA–DNA hybrids with significantly enhanced stability due to the absence of electrostatic repulsion, and the constrained flexibility of the polyamide backbone. Moreover, ultrasmall LDHs are engineered to load PNA and the obtained PNA‐loaded LDH platform (LDHs/PNA) is capable of efficiently and selectively targeting the intranuclear mutant sequences thanks to the proton sponge effect. Treatments with LDHs/PNA demonstrate markedly inhibited growth of pancreatic cancer xenografts via a cancer cell proliferation suppression mechanism. The results demonstrate the great potentials of LDHs/PNA as a highly promising gene therapy agent for PDAC.

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“…Assembly of both analytes and nanoparticles enables forming relatively uniform SERS system of molecular aggregates giving rise to good signal‐to‐noise ratio . This research topic is retrospect to early investigations on 2D Langmuir–Blodgett films . Recently, Luo et al .…”

Section: Sers/raman Of Molecular Aggregatesmentioning

confidence: 99%

Probing single molecules and molecular aggregates: Raman spectroscopic advances

Chen

Ding

Luo

et al. 2015

J. Raman Spectrosc.

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Development of Raman spectroscopy, profiting from surface‐enhanced Raman scattering and tip‐enhanced Raman scattering techniques, has inspired extensive research interest for trace analysis and dynamic measurements up to single‐molecule level. For another, Raman spectroscopy has also been recognized of significance in solving some important issues relating to molecule aggregates in chemistry and biology, owing to the capability of non‐destructive detection and high‐resolution fingerprints by which molecules and their aggregates can be identified. Herein, we summarize the recent progress of Raman spectroscopy in probing single molecules and molecular aggregates and block out a future prospective of Raman spectroscopy applied in cluster science. Copyright © 2015 John Wiley & Sons, Ltd.

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Fourier transform surface-enhanced Raman scattering of single-layer nucleolipid Langmuir–Blodgett films on silver island film substrates

Cited by 6 publications

References 34 publications

New Surface-Enhanced Raman Scattering Active Substrate Fabricated by Use of the Langmuir−Blodgett Technique

New Surface-Enhanced Raman Scattering Active Substrate Fabricated by Use of the Langmuir−Blodgett Technique

Efficient Gene Therapy of Pancreatic Cancer via a Peptide Nucleic Acid (PNA)‐Loaded Layered Double Hydroxides (LDH) Nanoplatform

Probing single molecules and molecular aggregates: Raman spectroscopic advances

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