Fourier transform IR imaging of primary tumors predicts lymph node metastasis of bladder carcinoma

Kujdowicz, Monika; Pérez-Guaita, David; Chłosta, Piotr; Okoń, Krzysztof; Malek, Kamilla

doi:10.1016/j.bbadis.2023.166840

Cited by 3 publications

(2 citation statements)

References 22 publications

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“…From our experience, in bladder and breast cancer, the lymphocytic inflammation, different tissue matrix response (f.e. fibrosis), and very small content of malignant cells might be the source of misdiagnosis, but sometimes it indicates a different prognosis [56][57][58][59][60][61]. There is no investigation into tumour nodule differences in patients with and without autoimmune disorders.…”

Section: Rs Perspectivesmentioning

confidence: 99%

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Kujdowicz,

Januś,

Taczanowska-Niemczuk

et al. 2023

IJMS

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The incidence of thyroid nodules (TNs) is estimated at 36.5% and 23% in females and males, respectively. A single thyroid nodule is usually detected during ultrasound assessment in patients with symptoms of thyroid dysfunction or neck mass. TNs are classified as benign tumours (non-malignant hyperplasia), benign neoplasms (e.g., adenoma, a non-invasive follicular tumour with papillary nuclear features) or malignant carcinomas (follicular cell-derived or C-cell derived). The differential diagnosis is based on fine-needle aspiration biopsies and cytological assessment (which is burdened with the bias of subjectivity). Raman spectroscopy (RS) is a laser-based, semiquantitative technique which shows for oscillations of many chemical groups in one label-free measurement. RS, through the assessment of chemical content, gives insight into tissue state which, in turn, allows for the differentiation of disease on the basis of spectral characteristics. The purpose of this study was to report if RS could be useful in the differential diagnosis of TN. The Web of Science, PubMed, and Scopus were searched from the beginning of the databases up to the end of June 2023. Two investigators independently screened key data using the terms “Raman spectroscopy” and “thyroid”. From the 4046 records found initially, we identified 19 studies addressing the differential diagnosis of TNs applying the RS technique. The lasers used included 532, 633, 785, 830, and 1064 nm lines. The thyroid RS investigations were performed at the cellular and/or tissue level, as well as in serum samples. The accuracy of papillary thyroid carcinoma detection is approx. 90%. Furthermore, medullary, and follicular thyroid carcinoma can be detected with up to 100% accuracy. These results might be biased with low numbers of cases in some research and overfitting of models as well as the reference method. The main biochemical changes one can observe in malignancies are as follows: increase of protein, amino acids (like phenylalanine, tyrosine, and tryptophan), and nucleic acid content in comparison with non-malignant TNs. Herein, we present a review of the literature on the application of RS in the differential diagnosis of TNs. This technique seems to have powerful application potential in thyroid tumour diagnosis.

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Section: Rs Perspectivesmentioning

confidence: 99%

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Kujdowicz,

Januś,

Taczanowska-Niemczuk

et al. 2023

IJMS

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“…Other promising applications of FTIR that have been recently investigated are the detection of melanoma metastases and lymph node metastases in thyroid and gastric cancer. FTIR imaging of the primary tumors in bladder, thyroid, and colon cancer has also been shown to predict metastatic spread [68][69][70][71][72][73].…”

Section: Fourier-transform Infrared Spectroscopymentioning

confidence: 99%

Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review

Papadoliopoulou,

Matiatou,

Koutsoumpos

et al. 2023

Cancers

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Assessment of regional lymph node status in breast cancer is of important staging and prognostic value. Even though formal histological examination is the currently accepted standard of care, optical imaging techniques have shown promising results in disease diagnosis. In the present article, we review six spectroscopic techniques and focus on their use as alternative tools for breast cancer lymph node assessment. Elastic scattering spectroscopy (ESS) seems to offer a simple, cost-effective, and reproducible method for intraoperative diagnosis of breast cancer lymph node metastasis. Optical coherence tomography (OCT) provides high-resolution tissue scanning, along with a short data acquisition time. However, it is relatively costly and experimentally complex. Raman spectroscopy proves to be a highly accurate method for the identification of malignant axillary lymph nodes, and it has been further validated in the setting of head and neck cancers. Still, it remains time-consuming. Near-infrared fluorescence imaging (NIRF) and diffuse reflectance spectroscopy (DFS) are related to significant advantages, such as deep tissue penetration and efficiency. Fourier-transform infrared spectroscopy (FTIR) is a promising method but has significant drawbacks. Nonetheless, only anecdotal reports exist on their clinical use for cancerous lymph node detection. Our results indicate that optical imaging methods can create informative and rapid tools to effectively guide surgical decision-making.

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Adipose-derived mesenchymal stem cells' adipogenesis chemistry analyzed by FTIR and Raman metrics

Augustyniak,

Lesniak,

Latka

et al. 2024

Journal of Lipid Research

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Fourier transform IR imaging of primary tumors predicts lymph node metastasis of bladder carcinoma

Cited by 3 publications

References 22 publications

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Raman Spectroscopy as a Potential Adjunct of Thyroid Nodule Evaluation: A Systematic Review

Optical Imaging in Human Lymph Node Specimens for Detecting Breast Cancer Metastases: A Review

Adipose-derived mesenchymal stem cells' adipogenesis chemistry analyzed by FTIR and Raman metrics

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