Fourier transform electrospray ion mobility spectrometry

Chen, Yong Hong; Siems, William F.; Hill, Herbert H.

doi:10.1016/s0003-2670(96)00251-6

Cited by 51 publications

(46 citation statements)

References 12 publications

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“…IMS techniques [34][35][36][37] and theory [38][39][40][41][42][43] as well as the instrumentation utilized to obtain IMS measurements [2,5,7,15,[44][45][46][47][48][49][50][51][52][53][54][55][56] have been described in detail elsewhere. Here, a detailed description of the new instrumentation is provided.…”

Section: Instrumentation Overviewmentioning

confidence: 99%

An Ion Mobility/Ion Trap/Photodissociation Instrument for Characterization of Ion Structure

Zucker

Lee

Webber

et al. 2011

J. Am. Soc. Mass Spectrom.

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A new instrument that combines ion mobility spectrometry (IMS) separations with tandem mass spectrometry (MS n ) is described. Ion fragmentation is achieved with vacuum ultraviolet photodissociation (VUV PD) and/or collision-induced dissociation (CID). The instrument is comprised of an approximately 1 m long drift tube connected to a linear trap that has been interfaced to a pulsed F 2 laser (157 nm). Ion gates positioned in the front and the back of the primary drift region allow for mobility selection of specific ions prior to their storage in the ion trap, mass analysis, and fragmentation. The ion characterization advantages of the new instrument are demonstrated with the analysis of the isomeric trisaccharides, melezitose and raffinose. Mobility separation of precursor ions provides a means of separating the isomers and subsequent VUV PD generates unique fragments allowing them to be distinguished.

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Section: Instrumentation Overviewmentioning

confidence: 99%

An Ion Mobility/Ion Trap/Photodissociation Instrument for Characterization of Ion Structure

Zucker

Lee

Webber

et al. 2011

J. Am. Soc. Mass Spectrom.

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“…Successful approaches trying to improve the situation, with special focus on the resolving power of IMS devices, concentrated especially on the electron source and the voltage schemes applied to the device. Regarding the electron source, prominent examples are electrospray ionization (typically for liquid samples) (Wittmer et al 1994, Chen et al 1996, Wu et al 2000, Harris et al 2008, Yamagaki and Sato 2009, optical sources (high-intensity light sources resp. laser, X-ray) (Matsaev et al 2002, Sielemann et al 2002, Oberh ü ttinger et al 2009 ), corona discharges (Tabrizchi et al 2000, Schmidt et al 2001, Khayamian et al 2003, Han et al 2007, Mulugeta et al 2010, Tabrizchi and Ilbeigi 2010, and electron guns (Gunzer et al 2010a ).…”

Section: Introductionmentioning

confidence: 99%

Pulsed electron beams in ion mobility spectrometry

Baether¹,

Zimmermann²,

Gunzer³

2012

Reviews in Analytical Chemistry

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Abstract:Ion mobility spectrometry is a well-known technique used to analyze trace gases in ambient air. Typically, it works by employing a radioactive source to provide electrons with high energy to ionize the analytes in a series of chemical reactions. During the past ten years non-radioactive sources have been one of the subjects of interest in ion mobility spectrometry, initially in order to replace radioactive sources as a result of general security and regulatory concerns. Among these non-radioactive sources especially pulsed sources have recently been shown to additionally improve the analytic information provided by ion mobility spectrometers. In this review we will describe the progress regarding the application of pulsed non-radioactive electron sources in ion mobility spectrometry and show the recent analytical advances that have been achieved by using pulsed electron beams.

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“…structure and size) reach after different drift times the detector. The techniques used to ionize the sample are as diverse as the fields of application of IMS: Electrospray [15][16][17][18][19], typically for liquid samples, optical (high intensity light sources [20,21] resp. laser [22,23], X-Ray [24]), or corona discharge [25][26][27][28], but the most common one especially in commercial devices is a radioactive source (mainly 63 Ni, but also 241 Am and 3 H).…”

Section: Introductionmentioning

confidence: 99%

A novel non-radioactive electron source for ion mobility spectrometry

Gunzer

Ulrich

Baether

2010

Int. J. Ion Mobil. Spec.

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Typical ion mobility spectrometers work by employing a radioactive source to provide electrons with high energy to ionize the analytes in a series of chemical reactions. General security as well as regulatory concerns related to the use of radioactivity resulted in a need for a different ionization source which on the other hand produces ions in a similar manner as a radioactive source because the mechanisms are well known. Here we introduce a novel non-radioactive electron source which is capable of providing high energy electrons in a way that is similar to beta radiating substances yielding correspondingly similar peak spectra.

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Fourier transform electrospray ion mobility spectrometry

Cited by 51 publications

References 12 publications

An Ion Mobility/Ion Trap/Photodissociation Instrument for Characterization of Ion Structure

An Ion Mobility/Ion Trap/Photodissociation Instrument for Characterization of Ion Structure

Pulsed electron beams in ion mobility spectrometry

A novel non-radioactive electron source for ion mobility spectrometry

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