Fourier phase analysis of SPECT equilibrium radionuclide angiography in symptomatic patients with mitral valve prolapse without significant mitral regurgitation: Assessment of biventricular functional abnormalities suggesting a cardiomyopathy

Casset-Senon, Danielle; Babuty, Dominique; Philippe, Laurent; Fauchier, Laurent; Eder, Véronique; Fauchier, J P; Pottier, Jean Marie; Delhomme, C; Cosnay, P

doi:10.1067/mnc.2000.107242

Cited by 13 publications

(6 citation statements)

References 24 publications

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“…30 However, these changes in deformations may be the first signs of future deterioration of the left ventricular systolic function by mitral valve prolapse progression. [16][17][18] Moreover, we found aortic root enlargement in young patients with prolapse. Mitral valve prolapse associated with aortic root enlargement is an independent predictor of greater aortic size not only in patients with systemic connective tissue disorders such as Marfan syndrome, but also in the general population.…”

Section: Discussionmentioning

confidence: 69%

“…Left ventricular contraction abnormalities in symptomatic mitral valve prolapse patients without severe mitral regurgitation but with ventricular arrhythmias have been described in some studies using cardiac tomography, radionuclide angiography, and single-photon emission computed tomography. [16][17][18] Moreover, a marked reduction in the myocardial deformation indices has been demonstrated in patients with degenerative severe mitral regurgitation. 19,20 Two-dimensional speckle-tracking echocardiography is a relatively new technique used for evaluation of the myocardial function.…”

Section: N Inherited Connective Tissue Disorders Thatmentioning

confidence: 99%

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Cardiomyopathy in young adults with classic mitral valve prolapse

et al. 2013

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Section: Discussionmentioning

confidence: 69%

Section: N Inherited Connective Tissue Disorders Thatmentioning

confidence: 99%

Cardiomyopathy in young adults with classic mitral valve prolapse

et al. 2013

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“…Вопрос о возможности снижения сократимости при первичном ПМК ставился ранее на основании исследований с использованием компьютерной томографии, радионуклидной ангиографии и одно-фотонной эмиссионной компьютерной томографии [8][9][10]. Было показано снижение показателей дефор-мации миокарда (strain) у пациентов с тяжелой деге-неративной МН [11,12].…”

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Systemic Involvement of Connective Tissue and the Heart as Important Characteristics of Primary Mitral Valve Prolapse

Земцовский¹,

Малев²,

Реева³

2014

Russ J Cardiol

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Цель. Оценка системного вовлечения соединительной ткани (СВСТ) у бес-симптомных пациентов молодого возраста с ПМК без значимой митральной регургитации. Материал и методы. В исследование было включено 78 пациентов с пролап-сом митрального клапана (ПМК) (средний возраст -19,7±1,6 лет; 72% юноши). Контрольную группу составили 80 здоровых лиц сопоставимого возраста и пола. Проведено фенотипическое обследование лиц с ПМК и конт рольной группы, и ЭхоКГ-исследование для выявления малых аномалий серд ца (МАС). Продольная деформация и скорость деформации миокарда оценивались с помощью методики spackle tracking (Vivid 7 Dim, EchoPAC'06, GE). Результаты. Было выделено два кластера пациентов с ПМК. В 1 кластере (17 человек, 28% от всей группы ПМК) наблюдалось значимое снижение про-дольной систолической деформации по сравнению с контрольной группой и вторым кластером (61 человек, 72%). Глобальный стрейн у лиц 2 кластера достоверно не отличался от контрольной группы. ЭхоКГ-исследование выя-вило недостоверное увеличение среднего числа баллов СВСТ в 1 кластере и высоко достоверное увеличение числа МАС в этой группе обследованных. Заключение. Оценка деформации миокарда позволила нам выявить у части молодых бессимптомных пациентов с ПМК признаки кардиомиопатии (КМП). Увеличение числа МАС в группе лиц с первичным ПМК и КМП позволяет рас-сматривать пролапсы других клапанов, расширение магистральных сосудов, базальные и толстые хорды ЛЖ в качестве признаков ВСТС при первичном ПМК. Наличие большого числа этих МАС при первичном ПМК может указывать на изменение экстрацеллюлярного матрикса сердца, способное стать причи-ной развития КМП при первичном ПМК. Российский кардиологический журнал 2014, 9 (113): 54-60Ключевые слова: пролапс митрального клапана, функция левого желудочка, малые аномалии сердца, системное вовлечение соединительной ткани. SYSTEMIC INVOLVEMENT OF CONNECTIVE TISSUE AND THE HEART AS IMPORTANT CHARACTERISTICS OF PRIMARY MITRAL VALVE PROLAPSEZemtsovsky E. V. Aim. To evaluate systemic involvement of connective tissue (SICT) in young adults with mitral valve prolapse (MVP) without significant mitral regurgitation (MR). Material and methods. We studied 78 asymptomatic young subjects (mean age 19,7±1,6, 72% male) with MVP in comparison with 80 sex-and age-matched healthy subjects. We performed phenotypic examination of MVP patients and control group subjects, and echocardiographic study to identify the minor heart anomalies. Longitudinal strain and strain rate (SR) were determined using spackle tracking (Vivid 7 Dimension GE, EchoPAC'08). Results. We identified two clusters of patients with MVP. In the first cluster (17 subjects, 28% of the MVP group) a significant reduction of longitudinal systolic strain observed comparing to the control group and the second cluster (61 subjects, 72%). Global strain in the second cluster did not differ significantly from the control group. Echocardiographic study showed nonsignificant increase in the average number of SICT points in the first cluster and highly significant increase of the...

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“…Both planar and SPECT RNA studies have demonstrated that phase analysis parameters could assess MD by characterizing abnormal cardiac (67,(78)(79)(80)(81) patterns and be a predictor of cardiac events (74,82). Other studies have also shown that phase analysis could differentiate between normal and MD patients with high accuracy (65,68,69,83…”

Section: Dyssynchrony Evaluationmentioning

confidence: 99%

Novel Spect Rna Quantification of Mechanical Dyssynchrony for the Prediction of CRT Response

Lalonde¹

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Mechanical dyssynchrony (MD) occurs when different regions of the heart wall contract out of phase, reducing the pumping efficiency of the heart and possibly leading to congestive heart failure (CHF). Cardiac resynchronization therapy (CRT) is a possible medical intervention for CHF that resynchronizes the heart, effectively reducing MD.However, CRT has been shown to provide no clinical benefit in 20-50% of recipients.Current CRT patient selection protocols do not include assessment of MD despite evidence that the mechanism of CRT response is to improve MD. Single-photon emission computed tomography (SPECT) radionuclide angiography (RNA) is an imaging technique that is capable of quantifying MD by accurately assessing cardiac wall motion.In this thesis, new methods of quantifying MD with SPECT RNA were developed and evaluated as a means to predict response to CRT.Novel Fourier-analysis (FA) amplitude values were compared to left ventricular (LV) scar size in the lateral wall to determine whether they can serve as surrogate markers for predicting response to CRT. Moderate but significant correlations (r=0.51, p≤0.05) were shown to exist between amplitude-and scar-based parameters. Lateral wall amplitude ii analysis was equivalent to lateral wall scar analysis for predicting response to CRT, but there were indications that amplitude may also be partly complementary to scar.Novel MD parameters were developed using FA amplitude parameters and by developing novel clustering algorithms. These novel MD parameters were evaluated alongside preestablished FA phase-based parameters in both global and segmental regions for their ability to predict CRT response. Using FA, septal wall amplitude standard deviation (SD), global synchrony and global phase-SD were significantly predictive of CRT response. Similar to the FA amplitude results, cluster analysis was predictive of CRT response using septal wall analysis. Based on the area under a receiver operating characteristic curve (AUC), there was an indication of improved predictive ability using cluster analysis (AUC=0.82) over scar analysis (AUC=0.73) and FA (AUC=0.78), but differences were not significant in the small test population.Novel amplitude-based FA parameters and cluster analysis approaches provide promising tools for the assessment of MD and the prediction of CRT response with SPECT RNA.iii both UOHI studies. The thesis author had no involvement in study design, patient assessment, CRT selection criteria; baseline scans or follows up assessments.Acquisitions were reconstructed following standard protocol by UOHI technicians. Positron emission tomography (PET) scar assessment was evaluated using FlowQuant © software (UOHI) by qualified UOHI technicians. Functional parameters such as left ventricular ejection fraction (LVEF) were analyzed with planar radionuclide angiography (RNA) acquisitions using the FUGA software (Hermes Medical Solutions) by qualified UOHI technicians. The statistical analysis of the double-blind RAFT data was performed by the Cardiovascular Rese...

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Fourier phase analysis of SPECT equilibrium radionuclide angiography in symptomatic patients with mitral valve prolapse without significant mitral regurgitation: Assessment of biventricular functional abnormalities suggesting a cardiomyopathy

Cited by 13 publications

References 24 publications

Cardiomyopathy in young adults with classic mitral valve prolapse

Cardiomyopathy in young adults with classic mitral valve prolapse

Systemic Involvement of Connective Tissue and the Heart as Important Characteristics of Primary Mitral Valve Prolapse

Novel Spect Rna Quantification of Mechanical Dyssynchrony for the Prediction of CRT Response

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