Fourier domain optical coherence tomographic and auto-fluorescence findings in indeterminate choroidal melanocytic lesions

Singh, Arun D.; Belfort, Rubens; Sayanagi, Kaori

doi:10.1136/bjo.2009.162636

Cited by 30 publications

(29 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sayanagi and coworkers used 3D spectral domain OCT and found a significantly higher prevalence of subretinal fluid (91% versus 14%), retinal edema (61% versus 14%), and subretinal deposits (61% versus 11%) in choroidal melanoma compared with nevi [10]. Singh and associates used spectral domain OCT to describe dispersed accumulation of subretinal deposits corresponding to orange pigment over a small choroidal melanoma that had not been found with time domain OCT [20]. Spectral domain OCT was also capable of detecting early vitreous seeding as highly reflective 20–30 micron spheroidal bodies in the vitreous [21].…”

Section: Choroidal Melanomamentioning

confidence: 99%

See 1 more Smart Citation

Optical Coherence Tomography of Retinal and Choroidal Tumors

Say

Shah

Ferenczy

et al. 2011

Journal of Ophthalmology

View full text Add to dashboard Cite

Optical coherence tomography (OCT) has revolutionized the field of ophthalmology since its introduction 20 years ago. Originally intended primarily for retina specialists to image the macula, it has found its role in other subspecialties that include glaucoma, cornea, and ocular oncology. In ocular oncology, OCT provides axial resolution to approximately 7 microns with cross-sectional images of the retina, delivering valuable information on the effects of intraocular tumors on the retinal architecture. Some effects include retinal edema, subretinal fluid, retinal atrophy, photoreceptor loss, outer retinal thinning, and retinal pigment epithelial detachment. With more advanced technology, OCT now provides imaging deeper into the choroid using a technique called enhanced depth imaging. This allows characterization of the thickness and reflective quality of small (<3 mm thick) choroidal lesions including choroidal nevus and melanoma. Future improvements in image resolution and depth will allow better understanding of the mechanisms of visual loss, tumor growth, and tumor management.

show abstract

Section: Choroidal Melanomamentioning

confidence: 99%

“…The limitation of OCT for choroidal melanoma lies in the difficulty of imaging the overlying retina for large melanomas and the inability to image past the anterior choroidal surface [19]. Reflectivity of the anterior choroid in melanoma is variable even with spectral domain OCT [20] (Figure 2). …”

Section: Choroidal Melanomamentioning

confidence: 99%

Optical Coherence Tomography of Retinal and Choroidal Tumors

Say

Shah

Ferenczy

et al. 2011

Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Dual-modal ophthalmic imaging [7,8] by combining OCT and AF could potentially be a valuable tool for the research and clinical diagnosis of AMD. Clinical ophthalmic imaging system manufacturers like Heidelberg and Topcon provide both OCT [9,10] and AF [11,12] instruments and have the option to combine these two imaging modalities.…”

Section: Introductionmentioning

confidence: 99%

“…Clinical ophthalmic imaging system manufacturers like Heidelberg and Topcon provide both OCT [9,10] and AF [11,12] instruments and have the option to combine these two imaging modalities. In non-ophthalmic imaging field, several groups have investigated the combination of OCT with AF imaging in different applications including cancer detection [13][14][15][16], heart imaging [17], morphological and biochemical tissues characterization [18,19], lung tissue imaging [20], and tissue imaging with needle probes [7,8,[13][14][15][16][17][18][19][20][21]. In these studies, two different light sources at different wavelengths were used for OCT and fluorescence excitation, i.e.…”

Section: Introductionmentioning

confidence: 99%

Simultaneous optical coherence tomography and lipofuscin autofluorescence imaging of the retina with a single broadband light source at 480nm

Jiang

Liu

et al. 2014

Biomed. Opt. Express

View full text Add to dashboard Cite

Abstract:We accomplished spectral domain optical coherence tomography and auto-fluorescence microscopy for imaging the retina with a single broadband light source centered at 480 nm. This technique is able to provide simultaneous structural imaging and lipofuscin molecular contrast of the retina. Since the two imaging modalities are provided by the same group of photons, their images are intrinsically registered. To test the capabilities of the technique we periodically imaged the retinas of the same rats for four weeks. The images successfully demonstrated lipofuscin accumulation in the retinal pigment epithelium with aging. The experimental results showed that the dual-modal imaging system can be a potentially powerful tool in the study of age-related degenerative retinal diseases. 1178-1181 (1991). 2. A. F. Fercher, "Optical coherence tomography," J. Biomed. Opt. 1(2), 157-173 (1996). 3. N. Ramanujam, "Fluorescence spectroscopy of neoplastic and non-neoplastic tissues," Neoplasia 2(1-2), 89-117 (2000). 4. W. Denk, J. H. Strickler, and W. W. Webb, "Two-photon laser scanning fluorescence microscopy," Science 248(4951), 73-76 (1990 7144-7158 (2006). 6. C. J. Kennedy, P. E. Rakoczy, and I. J. Constable, "Lipofuscin of the retinal pigment epithelium: a review," Eye (Lond.) 9(6), 763-771 (1995) 19653-19659 (2011). 31. S. Jiao, R. Knighton, X. Huang, G. Gregori, and C. Puliafito, "Simultaneous acquisition of sectional and fundus ophthalmic images with spectral-domain optical coherence tomography," Opt. Express 13(2), 444-452 (2005). 32. D. Grotte, V. Mattox, and R. Brubaker, "Fluorescent, physiological and pharmacokinetic properties of fluorescein glucuronide," Exp. Eye Res. 40(1), 23-33 (1985). 33. H. Xu, M. Chen, A. Manivannan, N. Lois, and J. V. Forrester, "Age-dependent accumulation of lipofuscin in perivascular and subretinal microglia in experimental mice," Aging Cell 7(1), 58-68 (2008).

show abstract

“…Several groups have investigated the combination of OCT with AF imaging and demonstrated the diagnostic capabilities of this combination by imaging pathological changes in different biological tissues. [4][5][6][7][8][9][10][11] In these studies, two different light sources at different wavelengths were used for OCT and fluorescence excitation. Accomplishing OCT and AF imaging with a single light source has not been demonstrated before.…”

mentioning

confidence: 99%