Four years' cytogenetic experience with the culture of chorionic villi

Sikkema‐Raddatz, Birgit; Bouman, Katelijne; Verschuuren‐Bemelmans, Corien C.; Stoepker, Marian; Mantingh, A.; Beekhuis, J. R.; Jong, Bauke M. de

doi:10.1002/1097-0223(200012)20:12<950::aid-pd959>3.0.co;2-v

Cited by 16 publications

(3 citation statements)

References 25 publications

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“…Another study in a Turkish population focused on the same issue and revealed a CA rate of 4.4% ( 12 ) . The medical literature reports culture media failure lower than 1.0% ( 11 , 13 , 14 , 15 ) and we observed approximately the same rate (1.2%). The patients and their spouses accepted the second attempt in only 7 of 27 cases (6 CVS and one AC) and a new AC was performed, all of which revealed a normal karyotype.…”

Section: Discussionsupporting

confidence: 81%

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Summary of 2185 prenatal invasive procedures in a single center: A retrospective analysis

Özcan

Uğur

Mustafa

et al. 2017

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Objective:To determine the frequency, indications, and outcomes of diagnostic invasive prenatal procedures (DIPP) performed in a university hospital.Materials and Methods:This retrospective, observational study included 2185 cases of DIPP (chorionic villus sampling, amniocentesis, and cordocentesis) performed at the department of obstetrics and gynecology of a university hospital between 2010 and 2016. We included all DIPP cases performed between 11 and 24 weeks of gestation. We compared the different types of DIPP performed in our hospital.Results:Two thousand one hundred eighty-five procedures were performed (1853 amniocenteses, 326 chorionic villus sampling, and 6 cordocenteses). The main indication for performing invasive procedures was abnormal results of aneuploidy screening for trisomy 21, followed by maternal age, and fetal structural abnormality. The fetal karyotype was altered in 154 (26.1%) cases. Trisomy 21 was the most common aneuploidy followed by trisomy 18, monosomy X, and trisomy 13. Fetal karyotype could not be revealed in 42 (2%) cases due to maternal contamination in 18 cases, inadequate sampling in 4 cases, and failure of cell culture in 27 cases. There were 2 pregnancy losses due to the invasive procedure (only in amniocentesis).Conclusion:The ideal approach to pregnancies with a detected chromosomal abnormality should be tailored according to the individual choice of the couples regarding whether they decide for or against a child with a known chromosomal abnormality.

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Section: Discussionsupporting

confidence: 81%

“…This low rate of mosaicism in our study may have resulted from the high AC preference with regard to CVS. The skill and practice of the obstetrician plays an important role in performing invasive procedures ( 14 , 15 , 24 ) . In our study, we observed only 2 abortions (0.09%) associated with invasive procedures.…”

Section: Discussionmentioning

confidence: 99%

Summary of 2185 prenatal invasive procedures in a single center: A retrospective analysis

Özcan

Uğur

Mustafa

et al. 2017

tjod

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“…The advantage of CVS is early diagnosis, while the benefits of AC are less placental mosaicism and a slightly lower rate of procedure related abortion. 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

An alternative perspective on prenatal invasive techniques: Comparison of pre-procedural anxiety and depression scores for patients undergoing chorion villus sampling and amniocentesis

et al. 2015

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Objective:To compare the pre-procedural anxiety and depression levels of patients undergoing chorion villus sampling (CVS) and amniocentesis (AC).Methods:Patients referred to our department for fetal karyotype analysis with a positive first or second trimester screening test for aneuploidy between January 2013 to June 2015 were included. CVS and AC procedures were performed in patients with gestation periods of between 11-14 and 16-20 weeks, respectively. Anxiety was evaluated using the Spielberger State-Trait Anxiety Inventory (STAI), and depression was assessed using the Beck Depression Inventory II (BDI-II).Results:A total of 1,400 patients were included. Compared to first trimester controls, patients undergoing CVS had significantly higher STAI-state and BDI-II results. Likewise, patients undergoing AC had higher STAI-state and BDI-II scores than controls in the second trimester. In terms of STAI-trait results, no difference was found between the groups. Our results also showed that, compared to AC group, patients undergoing CVS had similar STAI-state, STAI-trait and but higher BDI-II scores.Conclusion:We conclude that evaluating the stress and depression levels of these patients should be one of the routine procedures in pregnancy follow-up.

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Four years' cytogenetic experience with the culture of chorionic villi

Cited by 16 publications

References 25 publications

Summary of 2185 prenatal invasive procedures in a single center: A retrospective analysis

Summary of 2185 prenatal invasive procedures in a single center: A retrospective analysis

An alternative perspective on prenatal invasive techniques: Comparison of pre-procedural anxiety and depression scores for patients undergoing chorion villus sampling and amniocentesis

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