Four-year prospective study of pulmonary venous thrombosis after lung transplantation

Schulman, Larry L.; Anandarangam, Thiruvengadam; Leibowitz, David; DiTullio, Marco R.; McGregor, Carlton C.; Galantowicz, Mark; Homma, Shunichi

doi:10.1067/mje.2001.111855

Cited by 96 publications

(62 citation statements)

References 10 publications

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“…These thrombi sometimes cause embolism to vital organs [8,11]. Lung resection, lobectomy, lung torsion, and lung transplantation have previously been reported as causes of PV thrombus [12][13][14][15]. There are two types of thrombus in the PV stump after lobectomy.…”

Section: Discussionmentioning

confidence: 99%

Thrombosis in the Pulmonary Vein Stump After Left Upper Lobectomy as a Possible Cause of Cerebral Infarction

Ohtaka

Hida

Kaga

et al. 2013

The Annals of Thoracic Surgery

127

180

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OBJECTIVE: Thrombus in the stump of the pulmonary vein (PV) is not a well-known complication after lung resection, and it has the potential to cause embolism to vital organs. To clarify the frequency, risk factors, and cause of this complication, a retrospective clinical study of patients who underwent lobectomy was performed.METHOD: The subjects were 193 patients with primary lung cancer who underwent lobectomy from 2005 to 2011 and contrast-enhanced chest CT within 2 years after lobectomy. Contrast-enhanced CT was retrospectively interpreted to check for thrombus in the PV stump.RESULTS: The operative procedures were 65 right upper lobectomies, 14 right middle lobectomies, 40 right lower lobectomies, 52 left upper lobectomies (LUL), and 22 left lower lobectomies. Of the 193 patients, 7 (3.6%) developed thrombus in the PV stump after lobectomy. All patients with thrombus had undergone LUL, and 13.5% of those who had undergone LUL developed thrombus. Univariate analyses revealed that LUL and operation time were significant risk factors, and that adjuvant chemotherapy was marginally significant. It appears that thrombus may be attributable to the length of the PV stump. Measurement of the length of the PV stump using three-dimensional CT images of the PV revealed that the stump of the left superior PV was longer than the others.CONCLUSION: Thrombus in the PV stump occurred in 13.5% of cases after LUL. These findings suggest that contrast-enhanced CT should be recommended for patients after LUL to help identify patients with a high risk for thromboembolism.(246 words)

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Section: Discussionmentioning

confidence: 99%

Thrombosis in the Pulmonary Vein Stump After Left Upper Lobectomy as a Possible Cause of Cerebral Infarction

Ohtaka

Hida

Kaga

et al. 2013

The Annals of Thoracic Surgery

127

180

View full text Add to dashboard Cite

show abstract

“…The mechanism underlying PVT is poorly understood, but it is thought that iatrogenic or immunologic damage to the vein wall may stimulate thrombosis formation (1). In patients with malignancy, a hypercoagulable state or mechanical compression of the pulmonary vein may contribute to thrombosis (4).…”

Section: Discussionmentioning

confidence: 99%

“…It can present acutely with cough, dyspnoea, pleuritic chest pain, and haemoptysis or as a progressive deterioration in respiratory function (1,8).…”

Section: Discussionmentioning

confidence: 99%

“…A thrombus reaching the large distal veins and left atrium may be seen on TEE, but the diagnosis requires a high level of skill. CT is a non-invasive and reproducible diagnostic tool and is the recommended imaging modality for PVT (1). MRI plays a role in distinguishing tumor from thrombus in select cases (9).…”

Section: Discussionmentioning

confidence: 99%

“…However, successful clot resolution has been reported with anticoagulation (1,2). Early diagnosis and treatment can help to prevent the other potential complications, including pulmonary gangrene, peripheral embolus, and massive haemoptysis (3).…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Idiopathic Pulmonary Vein Thrombosis in a Patient with Chronic Obstructive Pulmonary Disease

Shand¹,

Bradley²,

Schauer³

2016

Eurasian J Pulmonol

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We present the case of a 67-year-old man who presented to our hospital with acute shortness of breath. He was initially treated for a presumed infective exacerbation of chronic obstructive pulmonary disease (COPD) but did not respond to standard therapy. Further investigations were performed and revealed a large pulmonary vein thrombus. Clinical, laboratory, and radiological investigation did not identify an underlying cause for his thrombus. Idiopathic pulmonary vein thrombosis is much rarer than the more well-known pulmonary embolism and is worthy of consideration as an uncommon cause of pulmonary decline. To our knowledge, this is the first case report in the English literature of idiopathic pulmonary vein thrombus occurring in the setting of known COPD.

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Pediatric Lung Transplantation

and

Sweet

2014

Textbook of Organ Transplantation

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Four-year prospective study of pulmonary venous thrombosis after lung transplantation

Cited by 96 publications

References 10 publications

Thrombosis in the Pulmonary Vein Stump After Left Upper Lobectomy as a Possible Cause of Cerebral Infarction

Thrombosis in the Pulmonary Vein Stump After Left Upper Lobectomy as a Possible Cause of Cerebral Infarction

Idiopathic Pulmonary Vein Thrombosis in a Patient with Chronic Obstructive Pulmonary Disease

Pediatric Lung Transplantation

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