Four-year experience with methotrexate exposures

LoVecchio, Frank; Katz, Kenneth D.; Watts, David J.; Wood, Ian

doi:10.1007/bf03161192

Cited by 24 publications

(20 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…LoVecchio et al reported 13 adults and children who had methotrexate exposure [5]. Our study had similar results to LoVecchio, in the fact that no patients had severe effects.…”

Section: Discussionsupporting

confidence: 89%

Acute Methotrexate Ingestions in Adults: A Report of Serious Clinical Effects and Treatments

Bebarta

Hensley

Borys

2014

Journal of Toxicology

View full text Add to dashboard Cite

Objective. Limited reported data have reports effects after acute ingestion of methotrexate. Treatment recommendations do not differentiate between exposure routes. Our objective was to determine the frequency of significant toxicity effects and use of therapy after methotrexate ingestion in adults. Methods. We performed a retrospective study on adult cases reported to 6 poison centers over 6 years (2000–2005) which exceed 180,000 exposures/year. Variables collected included demographics, dosages ingested, coingestions, clinical effects, and therapies with outcomes. Results. Sixty-three patients examined over the 6-year period met inclusion criteria. No patient in the series received dialysis or died. The mean dose ingested for all patients was 24 mg (range 2.5–100 mg) and the mean dose for suicidal ingestions was 47.5 mg (12.5–100 mg). The most common clinical effects were abdominal pain, oral irritation, throat irritation, nausea, dizziness, and headache. Nine patients received folinic acid and 3 patients received sodium bicarbonate. No patient developed renal failure, bone marrow suppression, seizure, or coma. No patient died or received dialysis. Conclusion. In our series of patients from 6 poison centers over six years, 63 cases of acute adult methotrexate ingestions were reported. Methotrexate toxicity from ingestion in adults was uncommon and rarely toxic.

show abstract

“…LoVecchio et al reported 13 adults and children who had methotrexate exposure [5]. Our study had similar results to LoVecchio, in the fact that no patients had severe effects.…”

Section: Discussionsupporting

confidence: 89%

Acute Methotrexate Ingestions in Adults: A Report of Serious Clinical Effects and Treatments

Bebarta

Hensley

Borys

2014

Journal of Toxicology

View full text Add to dashboard Cite

show abstract

“…Methotrexate (Mtx) is an anti-neoplastic and immunosuppressive agent widely used in the treatment of various malignancies and autoimmune diseases (1,2). It is toxic not only to cancer cells but also to normal cells.…”

Section: Introductionmentioning

confidence: 99%

“…Its cytotoxic characteristic causes some life-threatening adverse effects. One of the most serious side effect is hepatotoxicity, limiting the use of this agent (1)(2)(3)(4)(5). The mechanism of Mtx-induced hepatotoxicity has not been fully understood yet (6,7).…”

Section: Introductionmentioning

confidence: 99%

The effects of lycopene on methotrexate-induced liver injury in rats

Yucel¹,

Oğuz²,

Koçarslan³

et al. 2017

BLL

View full text Add to dashboard Cite

BACKGROUND: The aim of this study was to investigate the effects of lycopene (Lyc) on methotrexate (Mtx) induced liver toxicity in rats. METHODS: Twenty-eight male Sprague-Dawley rats were divided into four equal groups: control, Lyc, Mtx and Mtx-L: Control group: Rats were given only the vehicle. Lyc group: Rats were given Lyc (10 mg/kg) with corn oil by oral gavage for ten days. Mtx group: Rats were injected intraperitoneally with a single dose of 20 mg/kg of Mtx and given corn oil by oral gavage. Mtx-L group: Rats were post-treated with Lyc (10 mg/kg) for ten days after a single dose of Mtx (20 mg/kg). RESULTS: Mtx administration increased histopathological damage, TNF-α, IL-1β, TOS, TAS and OSI levels in tissues; AST, ALT levels in the blood. Sinusoidal dilatation, infl ammatory cell infi ltration and congestion were signifi cantly improved in the Mtx-L aon histopathologic examination of the rats. In Mtx-L group that were treated at the Lyc, TNF-α and IL-1β levels of liver tissue were decreased signifi cantly compared to Mtx group whereas the decrease in OSI was not signifi cant. Lyc treatment improved the AST and ALT values in Mtx-L group. But only AST improvement was signifi cant. CONCLUSIONS: The results of this study revealed that Lyc might be useful in protecting the liver from injury due to Mtx in rats by reducing the increased proinfl ammatory cytokine levels (Tab. 4, Fig. 1, Ref. 44). Text in PDF www.elis.sk.

show abstract

“…3 Autonomic effects, including tachycardia, hypersalivation, diaphoresis, emesis, bronchoconstriction, or uncoordinated voluntary muscle activity also occur. 4 Somatic motor symptoms include fasciculation, ataxia, restlessness, thrashing, and opsoclonus. 4 Scorpion antivenom has been a treatment option for severe stings since 1965 when a goat-derived whole IgG preparation was developed by Arizona State University.…”

mentioning

confidence: 99%

“…4 Somatic motor symptoms include fasciculation, ataxia, restlessness, thrashing, and opsoclonus. 4 Scorpion antivenom has been a treatment option for severe stings since 1965 when a goat-derived whole IgG preparation was developed by Arizona State University. 5 The preparation was never approved by the US Food and Drug Administration (FDA) and its production was discontinued in 1999.…”

mentioning

confidence: 99%

Antivenom Therapy of Scorpion Stings in Children

Benton¹

2009

AAP Grand Rounds

View full text Add to dashboard Cite

Four-year experience with methotrexate exposures

Cited by 24 publications

References 6 publications

Acute Methotrexate Ingestions in Adults: A Report of Serious Clinical Effects and Treatments

Acute Methotrexate Ingestions in Adults: A Report of Serious Clinical Effects and Treatments

The effects of lycopene on methotrexate-induced liver injury in rats

Antivenom Therapy of Scorpion Stings in Children

Contact Info

Product

Resources

About