Four- versus 6-minute infusion protocol for adenosine thallium-201 single photon emission computed tomography imaging

Stress Perfusion Imaging Using Cardiovascular Magnetic Resonance: A Review

“…For the adenosine infusion it is preferable to place two intravenous lines, one in each antecubital fossa. Adenosine is infused at 140 g/kg/min for 3-6 min [28], and the patient observed for an increase in heart rate (>10 beats/min) accompanied by a fall in blood pressure (>10 mm Hg). In the apparent absence of an appropriate physiologic response, an increased infusion rate up to 210 g/kg/min has been validated and found safe in patients with prior caffeine consumption [29].…”

Delayed heart rate recovery after adenosine stress testing with supplemental arm exercise predicts mortality

“…2,24 In addition, supplemental exercise may improve image quality and does affect the hemodynamics observed during the protocol. Elliot et al 25 and other investigators 26 have demonstrated that a protocol incorporating a 4-minute adenosine infusion with low-level exercise results in a marked reduction in the quantity and severity of adverse effects in addition to an improvement in MPI quality in comparison to a 6-minute adenosine infusion. The authors also showed that the mean peak HR during a 6-minute adenosine-only study is significantly lower than that achieved during the 4-minute adenosine/lowlevel exercise protocol.…”

Lipid Risk Factor Correlates of Ischemic Heart Disease as Diagnosed by Myocardial Perfusion Scintigraphy

“…Patients were stressed using either symptom limited treadmill exercise testing (Bruce, modified Bruce, or Naughton protocols), or pharmacologic stress testing with adenosine or dobutamine 19,20 …”