Four types of traditional Chinese medicine inducing epileptic seizures

Wu, Mengjiao; Fang, Min; Hu, Yun; Wang, Xuefeng

doi:10.1016/j.seizure.2012.02.010

Cited by 15 publications

(25 citation statements)

References 28 publications

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“…In modern times, industrial-scale production has developed with less rigorous quality control, and MPs have been regulated as food or food supplements or have been imported for use without regulation. Some WMPs have been associated with repeated, severe adverse reactions, including liver and kidney toxicity (sometimes fatal) [86–88], heavy metal poisoning [89–93], epileptic seizures [94], and adrenal suppression from undeclared addition of corticosteroids to herbal products [90]. There are further concerns regarding environmental contaminations (e.g., air pollution, soil contaminations), cultivation practices (e.g., pesticides, fungicides, microorganisms, endotoxins), manufacturing procedures (e.g., microorganisms, endotoxins), and inappropriate use [95, 96].…”

Section: Resultsmentioning

confidence: 99%

Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process

Baars

Hamre

2017

Evidence-Based Complementary and Alternative Medicine

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Background There is an increasing need for a worldwide professional integration of conventional medicine and traditional/complementary whole medical systems (WMSs). However, the integration is perceived by conventional medicine as problematic or unacceptable, because of a supposed lack of evidence for specific effects of WMSs therapies and supposed prescientific or unscientific paradigms of WMSs. Objectives To review the literature on the features of WMSs, similarities and differences between conventional medicine and WMSs, and scientific and clinical practice issues that should be dealt with in order to promote the integration process. Methods A critical, narrative review of the literature on six WMSs. Results and Conclusions Key factors for the integration of WMSs and conventional medicine are as follows: legal frameworks, quality standards, high-quality research on safety and efficacy of WMS interventions, infrastructure, and financial resources. For scientific assessment of WMSs, there are unresolved ontological, epistemological, and methodological issues and issues of diagnostics, therapy delivery, and outcome assessment in clinical practice. Future research not only should be directed at quality assurance and generating the necessary data on safety and efficacy/effectiveness but also should address more fundamental (ontological, epistemological, and methodological) issues, in order to overcome the differences between WMSs and conventional medicine.

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Section: Resultsmentioning

confidence: 99%

Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process

Baars

Hamre

2017

Evidence-Based Complementary and Alternative Medicine

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“…Ancak, beşbin yıldan daha fazla bir zamandan beri bitkisel kökenli ilaçlar epilepside kullanıl-maktadır. [15,16] Çalışmaya katılanların nöbet esnasındaki uygulamaları arasında, hastayı yan yatırma, ayakları yukarı kaldırma, yumuşak bir yere yatırmaya ek olarak dişler kilitlendiğinde arasına kaşık, havlu sokma bulunmaktaydı. Sidig ve ark.…”

Section: Discussionunclassified

Traditional Medicine Practices in Epilepsy: Sample of Canakkale

Tanrıverdi¹,

Gursoy²,

Şen³

et al. 2013

Epilepsi

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SummaryObjectives: The aim of this study was to define known Traditional Medicine (TM) practices in the city center of Canakkale.Methods: This descriptive research was conducted with patients aged 18 and above. The sample calculation formula for a known population was used. There were 553 individuals included in this study. Permissions were obtained from the relevant institutions. The data obtained by the researchers was generated using a face-to-face interview method, which was collected using a questionnaire over five months. The data was evaluated with SPSS 13. Results:In the study, 3.1% (n=17) of participants suffered from epilepsy either themselves or had at least one family member (mother, father, or siblings) with epilepsy; 8.3% (n=46) of the participants' second degree relatives suffered with epilepsy; 6% (n=33) had friends or neighbors that had been diagnosed with epilepsy; and 26.4% (n=146) of the participants knew of at least one TM method of how to cope with epilepsy. Conclusion:Health care professionals need to know the cultural characteristics of the society they are working in and be aware of TM methods used in order to increase the chances of success in treating patients with epilepsy.Key words: Epilepsy; traditional medicine; Canakkale. ÖzetAmaç: Bu çalışmanın amacı, epilepside bilinen geleneksel tıp uygulamalarını Çanakkale il merkezinde tanımlamaktır. Gereç ve Yöntem:Tanımlayıcı türde olan bu araştırma 18 yaş ve üzeri bireylerde yapıldı. Olasılıksız örneklem yöntemi ile çalışmaya katılmayı kabul eden 553 birey örnekleme dahil edildi. İlgili kurumlardan izinler alındı. Veriler araştırmacılar tarafından oluşturulan soru formu ile yüzyüze görüşme yöntemiyle Ocak-Mayıs 2011 tarihlerini kapsayan beş aylık süre içinde toplandı. Veriler SPSS 13 ile yüzdelik ve ortalama dağılımları şeklinde değerlendirildi. Bulgular: Çalışmaya katılanların %3.1'inin (n=17) kendileri de dahil olmak üzere anne, baba ve kardeşleri epilepsi hastasıydı. Yine katılımcıların %8.3'ünün (n=46) ikinci dereceden akrabaları, %6'sının (n=33) komşu ve arkadaşları epilepsi tanısı almıştı. Araştırmaya katılanların %26.4'ü (n=146) epilepsiye yönelik en az bir geleneksel tıp uygulaması biliyordu. Geleneksel tıp uygulamaları arasında yaygın bilinenler arasında soğan/sarımsak ve kolonya koklatma (n=40), psikolojik destek (n=31), nöbet sırasında dişler kenetlendiğinde kaşık sokmak (n=19), hocaya götürme, okunmuş su içirme ve muska yazdırma gibi dini uygulamalar (n=14) ile sigara içirme sayılabilir (n=7). Ek olarak yılan, kirpi eti, acı kavun, anzer balı yedirilmesi, badem kabuğunun kaynatılıp içirilmesi, kurşun döktürme, tokat atma ve su dökerek uyandırma diğer geleneksel tıp uygulamalarındandır.Sonuç: Sağlık çalışanlarının içinde yaşadığı toplumun kültürel özelliklerini iyi tanıması ve geleneksel tıp uygulamaları hakkında bilgi sahibi olması, hastaların tedavi yönetimlerinde başarı şansını arttıracaktır.Anahtar sözcükler: Epilepsi; geleneksel tıp; Çanakkale.KLİNİK ÇALIŞMA / ORIGINAL ARTICLE

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“…16 Da higher than that of strychnine, which indicated that they were isomers of hydroxylation or oxidation products of strychnine. + ) and similar dominant fragment ions, indicating that they were isomers.…”

Section: Tentative Identication Of the Sas Extractmentioning

confidence: 91%

“…A2 was conrmed as strychnine by comparing the retention time and MS 2 fragment ions with the authentic standard. In addition, the cleavage of the bonds between C 7 and C 17 , C 16 and C 19 , C 20 and C 21 generated the major fragment ion at m/z 306.11203 and described the position of the hydroxyl group only to be C 16 . Therefore, A1 was tentatively identied to be isostrychnine according to its accurate molecular mass and structural characteristic.…”

Section: Tentative Identication Of the Sas Extractmentioning

confidence: 99%

Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer

Zhang

Hou

et al. 2015

RSC Adv.

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Strychnos alkaloids (SAs) are considered to be the main toxic constituents in the traditional Chinese medicine, Semen Strychni. However, a general method for rapid identification of SAs in Semen Strychni and relative metabolites in serum has been time-consuming and difficult to develop due to the high similarity of their structures and physicochemical properties. Hence, this study was conducted to allow rapid and reliable characterization of the alkaloids in SAs extract, the constituents absorbed into blood as well as their metabolites in serum after oral administration of SAs extract based on high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer. The method we developed in the present study only required 16 min with high accurate multiple-stage mass spectrometry (MS n ) data. A total of 14 strychnos alkaloids, 5 of which were absorbed into serum, were detected and identified. Moreover, 22 metabolites in serum, including 19 phase I and 3phase II metabolites were observed and characterized. Results demonstrated that the use of the Q Exactive hybrid quadrupole-Orbitrap mass spectrometer proved to be a very feasible and efficient approach for the rapid separation and identification of the complex constituents in the extract and relative metabolites in vivo. In summary, our study will provide a deep insight into the toxic substances of Semen Strychni and deliver beneficial information for further understanding the in vivo behavior of strychnos alkaloid analogues.

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Four types of traditional Chinese medicine inducing epileptic seizures

Cited by 15 publications

References 28 publications

Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process

Whole Medical Systems versus the System of Conventional Biomedicine: A Critical, Narrative Review of Similarities, Differences, and Factors That Promote the Integration Process

Traditional Medicine Practices in Epilepsy: Sample of Canakkale

Identification of the toxic components in Semen Strychni and their metabolites in rat serum by high performance liquid chromatography coupled with a Q Exactive high-resolution benchtop quadrupole Orbitrap mass spectrometer

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