Four subtypes of childhood allergic rhinitis identified by latent class analysis

Abstract

Allergic rhinitis (AR) is common in childhood, 1 and its symptoms can have a major adverse impact on quality of life, emotional well-being, sleep, daily activities, and productivity of children and adolescents, especially when they are poorly controlled. 2 Traditionally, classification of AR is based on the temporal pattern of symptoms (as seasonal and perennial). Several other approaches to classify patients

Associations of Four sensitization patterns revealed by Latent Class Analysis with Clinical symptoms: A multi-center study of China

“…There is an abundance of evidence to support the associations of allergic sensitization with several clinical symptoms, for instance, asthma or rhinitis. 1 , 2 However, the complicated distribution of dominating allergens in different regions and sensitization to multiple allergens concurrently enable the patients to present complex anaphylaxis, 3 which poses a huge hinder in clinical diagnosis and therapy of allergy. 4 In traditional clinical practices, clinicians commonly use a skin prick test (SPT) or specific Immunoglobulin E (sIgE) measurement results in combination with the corresponding exposure history of allergens for clinical diagnosis of allergy.…”

Association between allergen component sensitisation and clinical allergic disease in children

“…14 In our study, LCA was unable to identify distinct phenotypes of allergic symptoms in relation to sensitisation patterns of allergen components. Although there are no clear guidelines on the desired sample size for LCA, 24 our study sample was relatively small compared to other studies using LCA, 27,28,30 which may have limited our power to identify distinct phenotypes. Future studies in larger clinical samples of children with allergic disease, using standardised methods to record the presence and severity of symptoms (like we did) and applying advanced statistical tests including machine learning techniques are needed to further elucidate the relationship between symptoms of allergic disease in children and their sensitisation patterns to multiple allergen components.…”

“…29 Recently, LCA has also been used to distinguish different phenotypes of children with allergic rhinitis. 30 We used LCA to identify patterns of different types of allergic symptoms (asthma, rhinitis, atopic dermatitis and food allergy) in relation to sensitisation to allergen and allergen components. The identification of a distinct phenotype of polysensitisation in this group of patients referred for allergy testing confirms earlier observations from population-based studies and clinical samples.…”

Allergic rhinitis in children: a comprehensive approach to treatment

“…фактор предпочтения пероральных антигистаминных препаратов топическим [14]. Эта позиция дискутабельна в т. ч. потому, что в перечне показаний к применению большинства антигистаминных средств отсутствуют атопический дерматит и БА, а для многих седативных пероральных антигистаминов обострение астмы является противопоказанием.…”

“…Актуальны сравнительные характеристики триггеров обострений АР у пациентов разных возрастных групп, а также пациентов с разным спектром сенсибилизации. Гетерогенность АР у детей и наличие клинико-патогенетических групп с разным прогнозом течения заболевания подчеркивается в свежих публикациях по проблеме [14,15].…”