Four stanniocalcin genes in teleost fish: Structure, phylogenetic analysis, tissue distribution and expression during hypercalcemic challenge

Schein, Vanessa; Cardoso, João C. R.; Pinto, Patrícia I. S.; Anjos, Liliana; Silva, Nádia; Power, Deborah M.; Canário, Adelino V.M.

doi:10.1016/j.ygcen.2011.11.033

Cited by 20 publications

(15 citation statements)

References 52 publications

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“…Blocking PTH signaling through the use of a PTH/PTHrP antagonist resulted in a decreased hypercalcemic response to estradiol in sea bream ( Sparus aurata ) [98]. Finally, four stanniocalcin ( stc ) genes are present in fugu and zebrafish, only stc1-a expression was sensitive to the calcium concentration in water [99]. [98] while PTHrP and Stc were shown to have opposing effects on calcium uptake in intestinal explants [100].…”

Section: Discussionmentioning

confidence: 99%

Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity

et al. 2015

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Teleost fish such as zebrafish (Danio rerio) are increasingly used for physiological, genetic and developmental studies. Our understanding of the physiological consequences of altered gravity in an entire organism is still incomplete. We used altered gravity and drug treatment experiments to evaluate their effects specifically on bone formation and more generally on whole genome gene expression. By combining morphometric tools with an objective scoring system for the state of development for each element in the head skeleton and specific gene expression analysis, we confirmed and characterized in detail the decrease or increase of bone formation caused by a 5 day treatment (from 5dpf to 10 dpf) of, respectively parathyroid hormone (PTH) or vitamin D3 (VitD3). Microarray transcriptome analysis after 24 hours treatment reveals a general effect on physiology upon VitD3 treatment, while PTH causes more specifically developmental effects. Hypergravity (3g from 5dpf to 9 dpf) exposure results in a significantly larger head and a significant increase in bone formation for a subset of the cranial bones. Gene expression analysis after 24 hrs at 3g revealed differential expression of genes involved in the development and function of the skeletal, muscular, nervous, endocrine and cardiovascular systems. Finally, we propose a novel type of experimental approach, the "Reduced Gravity Paradigm", by keeping the developing larvae at 3g hypergravity for the first 5 days before returning them to 1g for one additional day. 5 days exposure to 3g during these early stages also caused increased bone formation, while gene expression analysis revealed a central network of regulatory genes (hes5, sox10, lgals3bp, egr1, edn1, fos, fosb, klf2, gadd45ba and socs3a) whose expression was consistently affected by the transition from hyper- to normal gravity.

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Section: Discussionmentioning

confidence: 99%

Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity

et al. 2015

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“…In fish, the primary function of STC1 is related to calcium homeostasis, whereby STC1 (isoform A) is secreted by the CS in response to increased calcium in the blood protecting the animal against toxic hypercalcaemia (Schein et al, 2012;Wagner et al, 1986). Interestingly, T. nigroviridis kidney expresses both STC1-A and STC1-B (Schein et al, 2012) suggesting a potential paracrine Fig.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, T. nigroviridis kidney expresses both STC1-A and STC1-B (Schein et al, 2012) suggesting a potential paracrine Fig. 5.…”

Section: Discussionmentioning

confidence: 99%

“…Recently two fish STC1 isoforms encoded by paralogue genes have been identified: STC1-A strongly expressed in the CS and STC1-B only faintly expressed in various tissues (Schein et al, 2012). STC1-A stimulates phosphate reabsorption by renal proximal tubules, resulting in an increase in serum phosphate that combines with excess calcium to deposit into bone and scales (Lu et al, 1994).…”

Section: Introductionmentioning

confidence: 99%

“…STC1-A stimulates phosphate reabsorption by renal proximal tubules, resulting in an increase in serum phosphate that combines with excess calcium to deposit into bone and scales (Lu et al, 1994). Mammalian STC1 shares a high degree of amino acid sequence similarity (approximately 65e70%) with the fish STC1-A and STC1-B (Schein et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

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Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish

Schein

Kucharski

Guerreiro

et al. 2015

Molecular and Cellular Endocrinology

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The mammalian kidney contributes significantly to glucose homeostasis through gluconeogenesis. Considering that stanniocalcin 1 (STC1) regulates ATP production, is synthesized and acts in different cell types of the nephron, the present study hypothesized that STC1 may be implicated in the regulation of gluconeogenesis in the vertebrate kidney. Human STC1 strongly reduced gluconeogenesis from (14)C-glutamine in rat renal medulla (MD) slices but not in renal cortex (CX), nor from (14)C-lactic acid. Total PEPCK activity was markedly reduced by hSTC1 in MD but not in CX. Pck2 (mitochondrial PEPCK isoform) was down-regulated by hSTC1 in MD but not in CX. In fish (Dicentrarchus labrax) kidney slices, both STC1-A and -B isoforms decreased gluconeogenesis from (14)C-acid lactic, while STC1-A increased gluconeogenesis from (14)C-glutamine. Overall, our results demonstrate a role for STC1 in the control of glucose synthesis via renal gluconeogenesis in mammals and suggest that it may have a similar role in teleost fishes.

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Using zebrafish to study podocyte genesis during kidney development and regeneration

Kroeger

Wingert

2014

Genesis

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SUMMARY During development, vertebrates form a progression of up to three different kidneys that are comprised of functional units termed nephrons. Nephron composition is highly conserved across species, and an increasing appreciation of the similarities between zebrafish and mammalian nephron cell types has positioned the zebrafish as a relevant genetic system for nephrogenesis studies. A key component of the nephron blood filter is a specialized epithelial cell known as the podocyte. Podocyte research is of the utmost importance as a vast majority of renal diseases initiate with the dysfunction or loss of podocytes, resulting in a condition known as proteinuria that causes nephron degeneration and eventually leads to kidney failure. Understanding how podocytes develop during organogenesis may elucidate new ways to promote nephron health by stimulating podocyte replacement in kidney disease patients. In this review, we discuss how the zebrafish model can be used to study kidney development, and how zebrafish research has provided new insights into podocyte lineage specification and differentiation. Further, we discuss the recent discovery of podocyte regeneration in adult zebrafish, and explore how continued basic research using zebrafish can provide important knowledge about podocyte genesis in embryonic and adult environments.

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Four stanniocalcin genes in teleost fish: Structure, phylogenetic analysis, tissue distribution and expression during hypercalcemic challenge

Cited by 20 publications

References 52 publications

Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity

Zebrafish Bone and General Physiology Are Differently Affected by Hormones or Changes in Gravity

Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish

Using zebrafish to study podocyte genesis during kidney development and regeneration

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