Four single nucleotide polymorphisms (SNPs) are associated with resistance and resilience to Haemonchus contortus in Brazilian Morada Nova sheep

Haehling, Marei Borsch von; Cruvinel, G. G.; Toscano, J. H. B.; Giraldelo, L. A.; Santos, Isabella Barbosa dos; Esteves, S. N.; Benavides, Magda Vieira; Júnior, Waldomiro Barioni; Niciura, S. C. M.; Chagas, A. C. de S.

doi:10.1016/j.vetpar.2020.109053

Cited by 10 publications

(11 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On OAR12 a SNP at 63,873,649 kb was significant ( q -value = 0.011), which was located inside EDEM3 . In sheep, EDEM3 has been identified as a candidate gene for resistance to gastrointestinal nematodes [ 37 ]. This candidate gene highlights a challenge of studies that detect selective sweeps: Without phenotypes, we can’t know what trait has been selected on.…”

Section: Resultsmentioning

confidence: 99%

Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

Ghoreishifar

Rochus

Moghaddaszadeh-Ahrabi

et al. 2021

Genes

View full text Add to dashboard Cite

Gotland sheep, a breed native to Gotland, Sweden (an island in the Baltic Sea), split from the Gute sheep breed approximately 100 years ago, and since, has probably been crossed with other breeds. This breed has recently gained popularity, due to its pelt quality. This study estimates the shared ancestors and identifies recent selection signatures in Gotland sheep using 600 K single nucleotide polymorphism (SNP) genotype data. Admixture analysis shows that the Gotland sheep is a distinct breed, but also has shared ancestral genomic components with Gute (~50%), Karakul (~30%), Romanov (~20%), and Fjällnäs (~10%) sheep breeds. Two complementary methods were applied to detect selection signatures: A Bayesian population differentiation FST and an integrated haplotype homozygosity score (iHS). Our results find that seven significant SNPs (q-value < 0.05) using the FST analysis and 55 significant SNPs (p-value < 0.0001) using the iHS analysis. Of the candidate genes that contain significant markers, or are in proximity to them, we identify several belongings to the keratin genes, RXFP2, ADCY1, ENOX1, USF2, COX7A1, ARHGAP28, CRYBB2, CAPNS1, FMO3, and GREB1. These genes are involved in wool quality, polled and horned phenotypes, fertility, twining rate, meat quality, and growth traits. In summary, our results provide shared founders of Gotland sheep and insight into genomic regions maintained under selection after the breed was formed. These results contribute to the detection of candidate genes and QTLs underlying economic traits in sheep.

show abstract

Section: Resultsmentioning

confidence: 99%

Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

Ghoreishifar

Rochus

Moghaddaszadeh-Ahrabi

et al. 2021

Genes

View full text Add to dashboard Cite

show abstract

“…Provision of clean water free from fecal matter, proper drainage in the animal shed, avoiding overstocking in pastures and pens, and isolation of newly acquired animals to be aggressively dewormed to prevent the introduction of drug-resistant worms are some management practices for sustainable parasite control. Using host genetics to produce parasite-resistant and robust breeds like Red Maasai (Benavides et al 2015 ) and the Brazilian Morada Nova (Marei et al 2020 ) sheep is expected to be a long-term defense against internal parasites, such as the hematophagous H. contortus spp. Aside from targeting parasitic stages within the animal, biological control targeting free-living infective larvae on pasture by use of certain micro-fungi, particularly Duddingtonia flagrans , dung beetles, and earthworms, aims to reduce the number of infective stages available to susceptible grazing livestock (Canhão-Dias et al 2020 ; Mendoza-de Gives et al 2018 ; Szewc et al 2021 ).…”

Section: One-health Approach To Anthelmintic Drug Resistancementioning

confidence: 99%

Anthelmintic resistance in soil-transmitted helminths: One-Health considerations

Ng’etich,

Amoah,

Bux

et al. 2023

Parasitol Res

View full text Add to dashboard Cite

The One-Health approach recognizes the intricate connection between human, animal, and environmental health, and that cooperative effort from various professionals provides comprehensive awareness and potential solutions for issues relating to the health of people, animals, and the environment. This approach has increasingly gained appeal as the standard strategy for tackling emerging infectious diseases, most of which are zoonoses. Treatment with anthelmintics (AHs) without a doubt minimizes the severe consequences of soil-transmitted helminths (STHs); however, evidence of anthelmintic resistance (AR) development to different helminths of practically every animal species and the distinct groups of AHs is overwhelming globally. In this regard, the correlation between the application of anthelmintic drugs in both human and animal populations and the consequent development of anthelmintic resistance in STHs within the context of a One-Health framework is explored. This review provides an overview of the major human and animal STHs, treatment of the STHs, AR development and drug-related factors contributing towards AR, One-Health and STHs, and an outline of some One-Health strategies that may be used in combating AR.

show abstract

“…It should be possible to breed for more resistant sheep, both through conventional methods such as crossing with more resistant breeds (Amarante et al, 1999;Li et al, 2001), selection of stock for breeding on the basis of phenotypic measures such as FEC (Woolaston, 1992), weight gain in the face of challenge or PCV/FAMACHA © score (Burke and Miller, 2008;Riley and Van Wyk, 2009;Pereira et al, 2016) or, more recently, through the identification of genetic markers of resistance to haemonchosis and the use of these for the selection of breeding animals (Estrada-Reyes et al, 2019;Haehling et al, 2020).…”

Section: Breeding Haemonchosis-resistant Sheepmentioning

confidence: 99%

Haemonchosis: dealing with the increasing threat of the barber's pole worm

Crilly¹,

Evans

Tähepõld

et al. 2020

Livestock

View full text Add to dashboard Cite

Haemonchus contortus is a trichostrongyle nematode parasite of sheep and goats, and worldwide is considered to be the most important parasite of these species. It has a similar lifecycle to other parasitic trichostrongyle gastrointestinal nematodes, but it has a markedly higher fecundity, a preference for higher temperatures and a short pasture development time, which makes it epidemiologically different. Similarly, because of its blood-feeding habit the disease produced is distinct from parasitic gastroenteritis. This article summarises the differences in biology and control of H. contortus to other gastrointestinal nematodes of sheep, and covers specific control measures such as the use of FAMACHA© scoring, use of closantel and nitroxynil, the H. contortus vaccine, the effect of copper oxide wire particles, and the potential for breeding haemonchosis-resistant sheep and other future developments in H. contortus control.

show abstract

Four single nucleotide polymorphisms (SNPs) are associated with resistance and resilience to Haemonchus contortus in Brazilian Morada Nova sheep

Cited by 10 publications

References 43 publications

Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

Shared Ancestry and Signatures of Recent Selection in Gotland Sheep

Anthelmintic resistance in soil-transmitted helminths: One-Health considerations

Haemonchosis: dealing with the increasing threat of the barber's pole worm

Contact Info

Product

Resources

About