Four new prenylflavonol glycosides from the leaves of <i>Cyclocarya paliurus</i>

Ye, Zi-Jun; Sun, Huihui; Chen, Zu-Hui; Wu, Jianping; Li, Jing; Zhu, Hui; Huang, Lulu; Chang, Xi-Wen; Ou, Sai-Yu; Wang, Wen‐Xuan; He, Xiaoai; Zhu, Gangzhi; Xu, Kang‐Ping

doi:10.1080/14786419.2020.1803313

Cited by 10 publications

(4 citation statements)

References 11 publications

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“…Meanwhile, a small number of carbohydrates, proteins, mineral elements, sterols, amino acids, organic acids, and unsaturated fatty acids are present in this plant. [ 4 , 30 – 32 ]. These active substances are the material basis of drug efficacy.…”

Section: Extraction Of Effective Components From C Paliurusmentioning

confidence: 99%

Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of Type 2 Diabetes Mellitus

Wang

Tang

Gao

et al. 2021

Journal of Diabetes Research

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Type 2 diabetes mellitus (T2DM) is a common chronic metabolic disease that has become increasingly prevalent worldwide. It poses a serious threat to human health and places a considerable burden on global social medical work. To meet the increasing demand for T2DM treatment, research on hypoglycemic drugs is rapidly developing. Cyclocarya paliurus (Batal.) Iljinskaja is a medicinal plant that grows in China. The leaves of C. paliurus contain polysaccharides, triterpenoids, and other chemical components, which have numerous health benefits. Therefore, the use of this plant has attracted extensive attention in the medical community. Over the past few decades, contemporary pharmacological studies on C. paliurus extracts have revealed that it has abundant biological activities. Multiple in vitro and in vivo experiments have shown that C. paliurus extracts are safe and can play a therapeutic role in T2DM through anti-inflammatory and antioxidation activities, and intestinal flora regulation. Its efficacy is closely related to many factors, such as extraction, separation, purification, and modification. Based on summarizing the existing extraction methods, this article further reviews the potential mechanism of C. paliurus extracts in T2DM treatment, and we aimed to provide a reference for future research on natural plant medicine for the prevention and treatment of T2DM and its related complications.

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Section: Extraction Of Effective Components From C Paliurusmentioning

confidence: 99%

Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of Type 2 Diabetes Mellitus

Wang

Tang

Gao

et al. 2021

Journal of Diabetes Research

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“…Local and medical communities generally use CP leaves as functional foods or therapeutic agents [ 1 , 2 ]. CP leaves contain numerous active ingredients, including polysaccharides, triterpenoids, flavonoids, phenolic acids, and saponins [ 3 , 4 , 5 ]. Many studies have found that CP -derived triterpenoids possess various bioactivities, such as hypoglycemic, hypolipidemic, anti-inflammatory, and antioxidative stress effects [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

A Rational Combination of Cyclocarya paliurus Triterpene Acid Complex (TAC) and Se-Methylselenocysteine (MSC) Improves Glucose and Lipid Metabolism via the PI3K/Akt/GSK3β Pathway

Bai

Zhou

Luo³

et al. 2023

Molecules

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Cyclocarya paliurus (CP) contains triterpene acids that can improve glucose and lipid metabolism disorders. However, controlling the composition and content of these active ingredients in CP extracts is challenging. The main active components in CP triterpene acids, including ursolic acid (UA), oleanolic acid (OA), and betulinic acid (BA), exhibit antihyperglycemic and antihypertensive effects. The response surface methodology was utilized to design and optimize the ratio of UA, OA, and BA based on the inhibition rate of pancrelipase and α-amylase. The proportional mixture of UA, OA, and BA resulted in the formation of a complex known as Cyclocarya paliurus triterpenoid acid (TAC). Se-methylselenocysteine (MSC), a compound with various physiological functions such as antioxidant properties and tumor inhibition, has been used in combination with TAC to form the TAC/MSC complex. Our data demonstrate that TAC/MSC improved palmitic acid (PA)-induced insulin resistance in HepG2 cells through activating the phosphoinositide 3-kinase (PI3K) /protein kinase B (AKT)/glycogen synthase kinase 3 beta (GSK3β) pathway. Moreover, TAC/MSC effectively improved hyperglycemia, glucose intolerance, insulin resistance, and lipid metabolism disorder in mice with type 2 diabetes mellitus (T2DM), attenuated hepatic steatosis, and reduced oxidative stress to alleviate T2DM characteristics.

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“…Its cultivation method comprises cutting, grafting, layering, division, and sowing. Taking cuttings to produce seedlings has a more successful survival rate [21,22].…”

Section: Introductionmentioning

confidence: 99%

“…Its cultivation method comprises cutting, grafting, layering, division, and sowing. Taking cuttings to produce seedlings has a more successful survival rate [21,22]. The cultivation and growth of C. paliurus requires strict environmental controls, which limits its reproduction methods.…”

Section: Introductionmentioning

confidence: 99%

Technical Scheme for Cutting Seedlings of Cyclocarya paliurus under Intelligent Control of Environmental Factors

et al. 2023

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Cyclocarya paliurus is a species with high economic, horticultural, and medicinal value. C. paliurus grows faster than other plants, increasing the demand for propagation through leaf and stem cuttings to produce seedlings. However, this species requires pre-control of environmental factors such as high temperatures (25–30 °C), humidity (80–90%), and specific light (2000 to 3000 lux) intensity levels during the cutting and seedling production process. However, it is difficult to predict suitable environments for the growth of C. paliurus. This study requires the use of big data technology to parameterize the method of intelligent control of the environment used in the process of making stakes and creating seedlings. Our main results were that an improved convolutional neural network and short long-term memory (LSTM) in big data technology were used with a new method, multipath hole convolution (MPCNN), to predict environmental factors in production of seedlings. Also, the research results show that the MPCNN and LSTM methods can accurately predict the necessary temperature, humidity, and light conditions in the production process of C. paliurus seedlings. For the prediction of environmental characteristics related to this species, the light characteristics have a high error distribution, but the method described here was able to accurately control this variation, with an error of less than 2%.

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Four new prenylflavonol glycosides from the leaves of Cyclocarya paliurus

Cited by 10 publications

References 11 publications

Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of Type 2 Diabetes Mellitus

Potential Role of Natural Plant Medicine Cyclocarya paliurus in the Treatment of Type 2 Diabetes Mellitus

A Rational Combination of Cyclocarya paliurus Triterpene Acid Complex (TAC) and Se-Methylselenocysteine (MSC) Improves Glucose and Lipid Metabolism via the PI3K/Akt/GSK3β Pathway

Technical Scheme for Cutting Seedlings of Cyclocarya paliurus under Intelligent Control of Environmental Factors

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