2014
DOI: 10.1016/j.ijpharm.2013.10.049
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Four new polymorphic forms of suplatast tosilate

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Cited by 10 publications
(5 citation statements)
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“…Different hydrogen bonding modes may affect the crystals in many compounds, such as barbiturate derivatives, sulfonamides, and oxalic acid [252627]; thus, the occurrence of hydrogen bonds in the two valnemulin hydrogen tartrate polymorphs was assessed by comparing the IR spectra of Form I and Form II. As discussed in the theoretical study of geometries of valnemulin salts included in our previous work [14], there is hydrogen bonding between the valnemulin molecule and the tartaric acid molecule as –C=O (tartaric acid) … H–N (valnemulin).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Different hydrogen bonding modes may affect the crystals in many compounds, such as barbiturate derivatives, sulfonamides, and oxalic acid [252627]; thus, the occurrence of hydrogen bonds in the two valnemulin hydrogen tartrate polymorphs was assessed by comparing the IR spectra of Form I and Form II. As discussed in the theoretical study of geometries of valnemulin salts included in our previous work [14], there is hydrogen bonding between the valnemulin molecule and the tartaric acid molecule as –C=O (tartaric acid) … H–N (valnemulin).…”
Section: Discussionmentioning
confidence: 99%
“…Due to different crystallization conditions: such as solvents, temperature, pressure, and pseudoseeding with a crystal, different polymorphs may be obtained and which can have different arrangements of the molecule in the crystal [2628]. Moreover, polymorphic solids can have different chemical and physical properties and pharmaceutical effects.…”
Section: Discussionmentioning
confidence: 99%
“…The difference in crystal structure is due to the variation of intermolecular interactions between the molecules, resulting in alternative packing arrangements and leading to the occurrence of a new polymorph. [6] To tackle the challenge of polymorphism, a number of variables need to be considered, which represents an opportunity to produce new forms with improved physicochemical properties. The ultimate aim of crystallization is to produce a certain texture of the crystal to make the product acceptable.…”
Section: Introductionmentioning
confidence: 99%
“…The difference in crystal structure is due to the variation of intermolecular interactions between the molecules, resulting in alternative packing arrangements and leading to the occurrence of a new polymorph. [ 6 ]…”
Section: Introductionmentioning
confidence: 99%
“…Polymorphism of a drug compound usually results from the possibility of at least two different spatial arrangements of the molecules in the crystal lattice, or in some cases, from variations in molecular conformation, including crystalline and amorphous forms as well as solvate and hydrate forms [1][2][3][4].…”
Section: Introductionmentioning
confidence: 99%