“…The different species belonging to the genus Phomopsis are especially known for producing a wide variety of compounds with pharmacological properties, notably cytotoxic [ 30 , 31 , 32 ], antimicrobial [ 33 , 34 , 35 ], β -site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitory [ 36 ], anti-Tobacco mosaic virus (TMV) [ 37 ] and immunosuppressive activities [ 38 ]. As part of our research on discovering structurally novel and biologically active natural products from mangrove-derived endophytic fungal strains [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 ], a strain of Phomopsis asparagi DHS-48 isolated from the fresh root of Rhizophora mangle attracted our attention for the characterization of a series of immunosuppressive chromones [ 46 ] and cytochalasins [ 38 ]. In the present study, in order to tap the metabolic potential of this titled fungal strain, epigenetic manipulation was applied to activate its cryptic secondary biosynthetic pathways.…”