Four New Amaryllidaceae Alkaloids from Lycoris radiata and Their Cytotoxicity

Ang, Song; Liu, Xia-Mei; Huang, Xiao‐Jun; Zhang, Dongmei; Zhang, Wei; Wang, Lei; Ye, Wen‐Cai

doi:10.1055/s-0035-1557743

Cited by 12 publications

(25 citation statements)

References 19 publications

(26 reference statements)

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“…The most studied Lycoris species, L. radiata , also called spider lily, is a horticultural plant widely distributed in the south of China, Vietnam, Korea, Nepal and Malaysia [ 14 , 15 , 27 ]. Altogether 79 Aas have been either identified or isolated from either the bulbs or flowers of this plant ( Table 1 ).…”

Section: Phytochemistry Of the Genus Lycorismentioning

confidence: 99%

Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)

2020

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Lycoris Herbert, family Amaryllidaceae, is a small genus of about 20 species that are native to the warm temperate woodlands of eastern Asia, as in China, Korea, Japan, Taiwan, and the Himalayas. For many years, species of Lycoris have been subjected to extensive phytochemical and pharmacological investigations, resulting in either the isolation or identification of more than 110 Amaryllidaceae alkaloids belonging to different structural types. Amaryllidaceae alkaloids are frequently studied for their interesting biological properties, including antiviral, antibacterial, antitumor, antifungal, antimalarial, analgesic, cytotoxic, and cholinesterase inhibition activities. The present review aims to summarize comprehensively the research that has been reported on the phytochemistry and pharmacology of the genus Lycoris.

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Section: Phytochemistry Of the Genus Lycorismentioning

confidence: 99%

Chemistry and Biological Activity of Alkaloids from the Genus Lycoris (Amaryllidaceae)

2020

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“…Lycoranines C and D ( 13 and 14 , Figure ), and E and F ( 37 and 45 , Figure ), were isolated from the bulbs of Lycoris radiata (L'Hér.) together with homolycorine ( 35 ), haemanthidine ( 16 ), haemanthamine ( 15 ), α ‐dihydrolycorine, galanthine, lycorine ( 1 ), and pseudolycorine . L. radiata is mainly distributed in eastern Asia, particularly in China and Japan.…”

Section: Lycorenine Alkaloids Subgroupmentioning

confidence: 99%

“…In addition, the cytotoxic effects of these alkaloids were evaluated in vitro. Haemanthidine ( 16 ), haemanthamine ( 15 ), lycorine ( 1 ), and pseudolycorine exhibited a potent inhibitory effect against A549 and LoVo cells with 1.57 μM (Table ) …”

Section: Lycorenine Alkaloids Subgroupmentioning

confidence: 99%

“…together with homolycorine (35), haemanthidine (16), haemanthamine (15), α-dihydrolycorine, galanthine, lycorine (1), and pseudolycorine. 101 L. radiata is mainly distributed in eastern Asia, particularly in China and Japan. The bulbs of this plant have been used in traditional Chinese medicine for the treatment of different diseases.…”

Section: Lycoranines C-fmentioning

confidence: 99%

“…Haemanthidine (16), haemanthamine (15), lycorine (1), and pseudolycorine exhibited a potent inhibitory effect against A549 and LoVo cells with 1.57 μM (Table 1). 101 5 | MESEMBRINE ALKALOIDS SUBGROUP…”

Section: Lycoranines C-fmentioning

confidence: 99%

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Amaryllidaceae alkaloids: Absolute configuration and biological activity

et al. 2017

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Plants belonging to the Amaryllidaceae family are well known for their ornamental and medicinal use. Plant members of this group are distributed through both tropical and subtropical regions of the world and are dominant in Andean South America, the Mediterranean basin, and southern Africa. Amaryllidaceae plants have been demonstrated to be a good source of alkaloids with a large spectrum of biological activities, the latter being strictly related to the absolute stereochemistry of the alkaloid scaffold. Among them, great importance for practical applications in medicine has galanthamine, which has already spawned an Alzheimer's prescription drug as a potent and selective inhibitor of the enzyme acetylcholinesterase. Furthermore, lycorine as well as its related isocarbostyryl analogs narciclasine and pancratistatine have shown a strong anticancer activity in vitro against different solid tumors with malignant prognosis. This review addresses the assignment of the absolute configuration of several Amaryllidaceae alkaloids and its relationship with their biological activities.

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