Four Multiple Primary Malignant Neoplasms of the Aerodigestive Tract

Keshishian, Ara; Sarkar, Fazlul H.; Kucyj, George; Just-Viera, Jorge O.

doi:10.1016/s0003-4975(97)01196-x

Cited by 6 publications

(1 citation statement)

References 15 publications

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“…The combinations of colorectal malignancies with the other digestive system neoplasms including stomach and small intestinal tumors (10 males; 3 females) were frequently observed. Living habits may be an important contributing factor, such as unhealthy diet, tobacco smoking and alcohol consumption (Keshishian et al, 1998;Gursel et al, 2011), lack of exercise and so on. Not surprisingly, breast cancer was the most frequent first and second tumor among females in the present study, and consistent with the literature reported (Munker et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Multiple Primary Malignancies: a Retrospective Analysis of 72 Chinese Patients

Jiao¹,

Yao²,

Zhou³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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There is a scarcity of reports addressing patients with multiple primary malignancies (MPM), especially for Chinese cses. The aim of this study was to present a detailed analysis of Chinese patients presenting with at least two primary malignancies. Particularly, the clinical characteristics and survival between synchronous and metachronous MPM were compared. Out of 6,545 cases, 72 patients (1.1%) including 39 males (54.2%) and 33 females (45.8%) were diagnosed as MPM, giving a male: female sex ratio of 1.2:1. Of these, there were 16 (22.2%) cases of synchronous MPM (7 males, 9 females), 55(76.4%) metachronous (31 males, 24 females), and 1 "mixed form". For first tumor diagnosis time, synchronous MPM patients generally presented later than the metachronous cases. The top three sites for malignancies with metachronous MPM were colorectum, head and neck, and lung, while for synchronous they were lung, colorectum and breast. Among MPM patients, the median survival time was 15.7 years and the 5-year survival was 56%, and there was statistical difference in MPM categories (P < 0.05). The median survival time was 17.3 years and 3.8 years for metachronous and synchronous MPM patients, respectively. In comparison with synchronous MPM patients, those metachronous had a longer survival. This studies increase understanding of the clinical features of Chinese MPM patients and suggest that those presenting with metachronous cancers have a higher incidence and a better prognosis.

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Section: Discussionmentioning

confidence: 99%