Four-membered ring systems

Anaya, Josefa; Sánchez, Ramón M.

doi:10.1016/b978-0-443-18939-5.00018-4

Cited by 2 publications

(3 citation statements)

References 176 publications

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“…Beta-lactam antibiotics represent one of the major classes of antimicrobials. Emerging antibiotic resistance has compromised their antibacterial efficacy [8]. In some bacteria, particularly Gram-negative bacteria, beta-lactamases have evolved, i.e., enzymes that can break down beta-lactam antibiotics.…”

Section: Introductionmentioning

confidence: 99%

“…In some bacteria, particularly Gram-negative bacteria, beta-lactamases have evolved, i.e., enzymes that can break down beta-lactam antibiotics. The expression of beta-lactamases is one of the most studied and widespread mechanisms of antimicrobial resistance [8]. ESBL producers have been identified mainly in the taxonomic order Enterobacterales.…”

Section: Introductionmentioning

confidence: 99%

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Detection of Extended Spectrum ß-Lactamase-Producing Escherichia coli with Biofilm Formation from Chicken Meat in Istanbul

Aydin,

Suleymanoglu,

Abdramanov

et al. 2024

Foods

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Antimicrobial resistance is one of the major public health problems worldwide. This study aimed to detect the presence of extended-spectrum β-lactamase-(ESBL-)producing Escherichia (E.) coli in chicken meat in Istanbul, Türkiye. Raw chicken meat samples (n = 208) were collected from different sale points and analyzed for ESBL-producing E. coli. In total, 101 (48.5%) isolates were confirmed as E. coli by PCR, of which 80/101 (79.2%) demonstrated multiple antibiotic resistance. Resistance against amoxicillin-clavulanic acid was most frequent (87.1%). Eighteen isolates (17.8%) demonstrated phenotypical ESBL resistance, as assessed by the double disc synergy test (DDST). Isolates were tested for the presence of β-lactamase genes and mobilized colistin-resistant genes. The blaTEM group was most frequently detected (97.02%), followed by blaCTX m (45.5%), blaSHV (9.9%), and blaOXA-2 (0.9%). However, mcr genes and blaNDM, blaKPC, blaVIM, and blaOXA-48 genes were not found in any isolate. E. coli strains were tested for biofilm formation in six different media [Nutrient broth, LB broth, Tryptone Soya broth (TSB), TSB containing 1% sucrose, TSB containing 0.6% yeast extract, and BHI]. Biofilm formation by E. coli isolates (44/101, 43.5%) was highest in TSB with 1% sucrose. It is worth noting that all biofilm-producing isolates were found to harbor the blaTEM-1 gene, which can indicate a high level of antibiotic resistance. This is the first report about ESBL-producing E. coli in poultry meat, the exposure of consumers in Istanbul metropolitan areas, and the ability of E. coli from this region to produce biofilms.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detection of Extended Spectrum ß-Lactamase-Producing Escherichia coli with Biofilm Formation from Chicken Meat in Istanbul

Aydin,

Suleymanoglu,

Abdramanov

et al. 2024

Foods

View full text Add to dashboard Cite

show abstract

“…3 However, further investigation of bicycloalkanes for drug discovery has been hampered owing to their limited availability in nature and sophisticated preparation, even though substantial research efforts have been dedicated to the synthesis of single strained cyclic frameworks or bridged-rings. 4,5 Therefore, the invention of new synthetic methods for efficiently achieving highly constrained bicycloalkanes is crucial and highly desired. These methods would not only enhance the capabilities of chemists, but also expand the range of compounds available for drug discovery efforts.…”

Section: Introductionmentioning

confidence: 99%