Four‐dimensional transcatheter intra‐arterial perfusion MR imaging before and after uterine artery embolization in the rabbit VX2 tumor model

Chung, J.; Wang, Dingxin; Lewandowski, Robert J.; Tang, Richard; Chrisman, Howard B.; Vogelzang, Robert L.; Woloschak, Gayle E.; Larson, Andrew C.; Omary, Reed A.; Ryu, Robert K.

doi:10.1002/jmri.22134

Cited by 3 publications

(2 citation statements)

References 27 publications

(37 reference statements)

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“…DSA imaging was used smoothly in above rabbit uterine tumor model as a functional imagery way to obtain blood perfusion by a mask subtraction method. The imaging obtained before urografin given was used to produce a mask, which was subtracted [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities

Guan

2017

Oncotarget

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ObjectivesTo evaluate damage effect of High-intensity focused ultrasound on early stage endometrial cancer tissues and their vascularities.Materials and MethodsRabbit endometrial cancer models were established via tumor blocks implantation for a prospective control study. Ultrasonic ablation efficacy was evaluated by pathologic and imaging changes. The target lesions of experimental rabbits before and after ultrasonic ablation were observed after autopsy. The slides were used for hematoxylin-eosin staining, elastic fiber staining and endothelial cell staining; the slides were observed by optical microscopy. One slide was observed by electron microscopy. Then the target lesions of experimental animals with ultrasonic ablation were observed by vascular imaging, one group was visualized by digital subtract angiography, one group was quantified by color Doppler flow imaging, and one group was detected by dye perfusion.SPSS 19.0 software was used for statistical analyses.ResultsHistological examination indicated that High-intensity focused ultrasound caused the tumor tissues and their vascularities coagulative necrosis. Tumor vascular structure components including elastic fiber, endothelial cells all were destroyed by ultrasonic ablation. Digital subtract angiography showed tumor vascular shadow were dismissed after ultrasonic ablation. After ultrasonic ablation, gray-scale of tumor nodules enhanced in ultrasonography, tumor peripheral and internal blood flow signals disappeared or significantly reduced in color Doppler flow imaging. Vascular perfusion performed after ultrasonic ablation, tumor vessels could not filled by dye liquid.ConclusionHigh-intensity focused ultrasound as a noninvasive method can destroy whole endometrial cancer cells and their supplying vascularities, which maybe an alternative approach of targeted therapy and new antiangiogenic strategy for endometrial cancer.

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Section: Discussionmentioning

confidence: 99%

Destructive effect of HIFU on rabbit embedded endometrial carcinoma tissues and their vascularities

Guan

2017

Oncotarget

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“…Embolization follow up showed that the procedure was successful when fibroids were unenhanced and the uterine arteries were invisible on perfusion MRI [27] . In a rabbit tumor model, Chung et al [28] used intra-arterial bolus injection of gadoliniumbased MR contrast medium to measure uterine fibroid perfusion before and after uterine artery embolization. After positioning a catheter within the uterine artery and injecting the microemboli, they found that uterine tumor perfusion decreased by 76% on MRI.…”

Section: Body Interventionsmentioning

confidence: 99%

Value of MR contrast media in image-guided body interventions

Saeed¹

2012

WJR

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In the past �ew years, there have been multiple advances in magnetic resonance (MR) instrumentation, in vivo devices, real-time imaging sequences and interventional procedures with new therapies. More recently, interventionists have started to use minimally invasive image-guided procedures and local therapies, which reduce the pain �rom conventional surgery and increase drug e��ectiveness, respectively. Local therapy also reduces the systemic dose and eliminates the toxic side e��ects o� some drugs to other organs. The success o� MR-guided procedures depends on visualization o� the targets in 3D and precise deployment o� ablation catheters, local therapies and devices. MR contrast media provide a wealth o� tissue contrast and allows 3D and 4D image acquisitions. A�ter the development o� �ast imaging sequences, the clinical applications o� MR contrast media have been substantially expanded to include pre-during-and post-interventions. �rior to intervention, MR contrast media have the potential to localize and delineate pathologic tissues o� vital organs, such as the brain, heart, breast, kidney, prostate, liver and uterus. They also o��er other options such as labeling therapeutic agents or cells. During intervention, these agents have the capability to map blood vessels and enhance the contrast between the endovascular guidewire/catheters/devices, blood and tissues as well as direct therapies to the target. Furthermore, labeling therapeutic agents or cells aids in visualizing their delivery sites and tracking their tissue distribution. A�ter intervention, MR contrast media have been used �or assessing the efficacy of ablation and therapies. It should be noted that most image-guided procedures are under preclinical research and development. It can be concluded that MR contrast media have great value in preclinical and some clinical interventional procedures. Future applications o� MR contrast media in image-guided procedures depend on their sa�ety, tolerability, tissue speci�icity and e��ectiveness in demonstrating success o� the interventions and therapies.

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