Four-dimensional optoacoustic monitoring of tissue heating with medium intensity focused ultrasound

Landa, Francisco Javier Oyaga; Peñacoba, Silvia Ronda; Espinosa, F. Montero de; Razansky, Daniel; Deán‐Ben, Xosé Luís

doi:10.1016/j.ultras.2018.11.011

Cited by 13 publications

(10 citation statements)

References 53 publications

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“…Kim et al [147] designed a HIFU-living photoacoustic thermometry system with clinical US imaging with the feasibility of achieving safe and effective monitoring during the real-time treatment. Landa et al [148] demonstrated the optoacoustic monitored temperature variations with simultaneous thermocouple readings, and are regarded as 4D optoacoustic monitoring of tissue heating. Giurazza et al [149] conducted a preliminary analysis of thermometry based on ultrasound elastography and evaluated the feasibility of ultrasonic thermometry using specific ultrasound imaging technology based on elastography ARFI for laser ablation of biological tissue, though the results were not satisfactory.…”

Section: Real-time Temperature Monitoringmentioning

confidence: 99%

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

2021

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As a novel noninvasive therapeutic modality combining low-intensity ultrasound and sonosensitizers, sonodynamic therapy (SDT) is promising for clinical translation due to its high tissue-penetrating capability to treat deeper lesions intractable by photodynamic therapy (PDT), which suffers from the major limitation of low tissue penetration depth of light. The effectiveness and feasibility of SDT are regarded to rely on not only the development of stable and flexible SDT apparatus, but also the screening of sonosensitizers with good specificity and safety. To give an outlook of the development of SDT equipment, the key technologies are discussed according to five aspects including ultrasonic dose settings, sonosensitizer screening, tumor positioning, temperature monitoring, and reactive oxygen species (ROS) detection. In addition, some state-of-the-art SDT multifunctional equipment integrating diagnosis and treatment for accurate SDT are introduced. Further, an overview of the development of sonosensitizers is provided from small molecular sensitizers to nano/microenhanced sensitizers. Several types of nanomaterial-augmented SDT are in discussion, including porphyrin-based nanomaterials, porphyrin-like nanomaterials, inorganic nanomaterials, and organic-inorganic hybrid nanomaterials with different strategies to improve SDT therapeutic efficacy. There is no doubt that the rapid development and clinical translation of sonodynamic therapy will be promoted by advanced equipment, smart nanomaterial-based sonosensitizer, and multidisciplinary collaboration.

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Section: Real-time Temperature Monitoringmentioning

confidence: 99%

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

2021

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“…shown to be sensitive to temperature variations. 140,141 This has been exploited to monitor hyperthermia-induced vasodilation in the human skin. 142 Multi-spectral OA imaging has been used…”

Section: Other Applicationsmentioning

confidence: 99%

Optoacoustic imaging of the skin

Deán‐Ben

Razansky

2021

Experimental Dermatology

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Optoacoustic (OA, photoacoustic) imaging capitalizes on the synergistic combination of light excitation and ultrasound detection to empower biological and clinical investigations with rich optical contrast while effectively bridging the gap between micro and macroscopic imaging realms. State-of-the-art OA embodiments consistently provide images at micron-scale resolution through superficial tissue layers by means of focused illumination that can be smoothly exchanged for acoustic-resolution images at diffuse light depths of several millimetres to centimetres via ultrasound beamforming or tomographic reconstruction. Taken together, this unique multi-scale imaging capacity opens unprecedented capabilities for high-resolution in vivo interrogations of the skin at scalable depths. Moreover, diverse anatomical and functional information is retrieved via dynamic mapping of endogenous chromophores such as haemoglobin, melanin, lipids, collagen, water and others. This, along with the use of non-ionizing radiation, facilitates a clinical translation of the OA modalities. We review recent progress in OA imaging of the skin in preclinical and clinical studies exploiting the rich contrast provided by endogenous substances in tissues. The imaging capabilities of existing approaches are discussed in the context of initial translational studies on skin cancer, inflammatory skin diseases, wounds and other conditions.

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“…Intravascular access is also possible, and dedicated probes can find important applications such as the characterization of human coronary atherosclerosis [12,150,166,167]. Potentially important diagnostic feature of the OA method is its high sensitivity to temperature variations as well as ability to spectrally differentiate coagulated tissues, which can be employed for monitoring ablation procedures and other thermal interventions [168][169][170][171][172][173].…”

Section: Perspectivementioning

confidence: 99%

Optoacoustic image formation approaches—a clinical perspective

Deán‐Ben

Razansky

2019

Phys. Med. Biol.

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Clinical translation of optoacoustic imaging is fostered by the rapid technical advances in imaging performance as well as the growing number of clinicians recognizing the immense diagnostic potential of this technology. Clinical optoacoustic systems are available in multiple configurations, including hand-held and endoscopic probes as well as raster-scan approaches. The hardware design must be adapted to the accessible portion of the imaged region and other application-specific requirements pertaining the achievable depth, field of view or spatio-temporal resolution. Equally important is the adequate choice of signal and image processing approach, which is largely responsible for the resulting imaging performance. Thus, new image reconstruction algorithms are constantly evolving in parallel to the newly-developed setups. This review focuses on recent progress on optoacoustic image formation algorithms and processing methods in the clinical setting. Major reconstruction challenges include real-time image rendering in two and three dimensions, efficient hybridization with other imaging modalitites as well as accurate interpretation and quantification of bio-markers, herein discussed in the context of ongoing progress in clinical translation. I.

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Four-dimensional optoacoustic monitoring of tissue heating with medium intensity focused ultrasound

Cited by 13 publications

References 53 publications

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Optoacoustic imaging of the skin

Optoacoustic image formation approaches—a clinical perspective

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