Four diclofenac complexes with cobalt(II) and nickel(II) ions: synthesis, spectroscopic properties, thermal decompositions, crystal structures, and carbonic anhydrase activities

Abstract

Cobalt(II) and nickel(II) complexes with diclofenac (dicl) in the presence of nitrogen-donor 3-picoline (3-pic) and 1-(2-aminoethyl)pyrrolidine (2-aepyr), [Co(dicl) 2 (3-pic) 2 ] (1), [Ni(dicl) 2 (3-pic) 2 (H 2 O) 2 ] (2), [Co(dicl) 2 (2-aepyr) 2 ] (3), and [Ni(dicl) 2 (2-aepyr) 2 ] (4), have been synthesized and characterized by FT-IR, UV-Vis, elemental and thermal analysis. The crystal structures of 1 and 3 have been determined by single-crystal X-ray diffraction; phase purity of complexes has been proved by powder X-ray diffraction analysis. Structural analyses have demonstrated that 1 and 3 are mononuclear and Co(II) ions have distorted octahedral environments. In 1, dicl is bidentate, whereas in 2, 3, and 4 dicl is monodentate. Dicl ligands are coordinated to metal(II) ions with O of carboxylate. Therefore, IR spectra of all complexes display {ν(OCO) asym and ν(OCO) sym } of dicl. The calculated Δν(OCO) values are consistent with the presence of monodentate (>200) and bidentate (<200) carboxylate. Compounds 2, 3, and 4 exhibit inhibition effects on human carbonic anhydrase-I. Compounds 3 and 4 show high thermal stability compared with 1 and 2.

Crystal structure of a mixed-ligand silver(I) complex of the non-steroidal anti-inflammatory drug diclofenac and pyrimidine

“…(Kim et al, 2004;Ribeiro et al, 2008;Duffy et al, 1998). In previous publications, the crystal structures of metal complexes of diclofenac have been reported (Caglar et al, 2013(Caglar et al, , 2014Ali & Jabali, 2016;Dimiza et al, 2011;Kovala-Demertzi et al, 1997;Castellari et al, 1999;Kourkoumelis et al, 2004) and in addition its molecular structure has been characterized by various techniques (Iliescu et al, 2004). Based on the above-mentioned points, we report herein the synthesis and structural characterization of a new mixedligand silver(I) complex with dicl and pyrimidine (pym), namely [Ag(-dicl)(-pym)] n , (I).…”

Evaluation of antioxidant and antiproliferative activities of 1,2‐bis (p‐amino‐phenoxy) ethane derivative Schiff bases and metal complexes

“…Vitamins A, E, and C levels were reduced by the treatment of compounds and especially Cu (II) complexes were decreased (Table ). In recent studies, copper coordination with TSC and SB ligands were comprehensively studied . Some of these research were known to generate severe cytotoxicity with of the production of reactive oxygen species .…”

Synthesis, crystal structures and characterizations of three new copper(II) complexes including anti-inflammatory diclofenac

“…Until now, different metal complexes, including manganese(II), cobalt(II), nickel(II), zinc(II), cadmium(II), tin(II) and silver(I) centres, with diclofenac in the presence of nitrogendonor ligands, have been investigated (Banti & Hadjikakou, 2016;Theodorou et al, 1999;Kovala-Demertzi, 2000;Caglar, Aydemir et al, 2014;Zampakou, Hatzidimitriou et al, 2015;Zampakou, Tangoulis et al, 2015;Dimiza et al, 2011;Hamamci Alisir et al, 2016Kyropoulou et al, 2013;Abu Ali et al, 2016;Refat et al, 2014). However, there are only a few reports related to mixed-ligand copper(II)-dicl complexes in the literature (Kumar et al, 2018;Caglar et al, 2013Caglar et al, , 2016Dimiza et al, 2011).…”