Four-component synthesis of 3-aminomethylated imidazoheterocycles in EtOH under catalyst-free, oxidant-free and mild conditions

Abstract

The 3-aminomethylated imidazoheterocycles were efficiently synthesized in one-step via a four-component reaction of equimolar cheap and commercially available reactants at ambient temperature under catalyst-, oxidant-, base-free and mild conditions.

Study and application of graphene oxide in the synthesis of 2,3-disubstituted quinolinesviaa Povarov multicomponent reaction and subsequent oxidation

“…5 MCRs are one-pot reactions where three or more reagents are combined in the same reaction vessel, to obtain a product that contains the largest possible number of atoms of the reagents. [6][7][8][9] Recently, the range of possible multicomponent reactions has been greatly expanded by using photocatalysis and electrocatalysis. [10][11][12][13] When MCRs are included in a one-pot multistep process the advantages multiply, saving time and energy (step and operational efficiency) and reducing waste, therefore approaching the concept of an ideal eco-friendly synthesis.…”

Enantioselective synthesis of α-tetrasubstituted (3-indolizinyl) (diaryl)methanamines via chiral phosphoric acid catalysis

“…Chiral α-tetrasubstituted methanamines are frequently distributed in diverse bioactive natural products, 1 and extensive effort has been devoted to constructing these scaffolds in synthetic chemistry over the past decade. 2 Some excellent chiral organocatalysts 3 and chiral metal salt catalysts 4 have been developed in the asymmetric synthesis of chiral α-tetrasubstituted (diaryl)alkyl or (triaryl) methanamines. Despite these notable advances, to the best of our knowledge, there are currently no versatile protocols for the asymmetric preparation of chiral α-(3-indolizinyl)(diaryl) methanamines.…”

Nickel supported on magnetic biochar as a highly efficient and recyclable heterogeneous catalyst for the one‐pot synthesis of spirooxindole‐dihydropyridines

“…For sustainable development, green synthesis is highly desirable focusing on environment‐friendly manufacturing to reduce toxic or polluting waste generated in chemical processes. [ 12,13 ] Significant efforts have been made to develop heterogeneous catalysts in combination with MCRs in green solvents for the construction of biologically active compound. [ 14,15 ] Specifically, biochar (BC) materials have received considerable attention due to their excellent chemical stability, low cost, simple and cheap preparation, low toxicity, high porosity, large specific surface area, and adjustable surface function.…”