Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants

Nagasaka, Miharu; Maeda, Sakan; Maeda, Hitoshi; Hui-ling, Chen; Kita, K; Mabuchi, Osamu; Misu, Hideo; Matsuo, Tamotsu; Sugiyama, Taketoshi

doi:10.1182/blood.v61.6.1174.1174

Cited by 108 publications

(13 citation statements)

References 21 publications

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“…Ultrastructural, cytochemical, immunological and maturation induction techniques have been used. All but one of the cases tested have been negative for the c-ALL antigen (TIWCL 1980(TIWCL , 1981aEsseltine et al, 1982;Arthur et al, 1982;Morse et al, 1982;Parkin et al, 1982;Nagasaka et al, 1983;Walther et al, 1983;Secker-Walker, 1984;Levin et al, 1984). The features reported indicate a pluripotent target cell capable of myeloid or lymphoid development similar to that in Philadelphia ( P h l ) positive chronic myeloid leukaemia (Greaves, 1982).…”

Section: Discuss I 0 Nmentioning

confidence: 99%

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The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations

Secker-Walker

Stewart

et al. 1985

Br J Haematol

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Case reports of four girls and one boy with acute lymphoblastic leukaemia (ALL) or acute myeloid leukaemia (AML) and t(4;11) are presented. The incidence of t(4;11) ascertained at diagnosis in ALL was 2.6% and in AML 5.3%. Four of the children were under 2 years and one was 11 years at diagnosis. Leucocyte counts above 71 X 10(9)/l and liver, spleen and node enlargement were found in all cases. Blasts of the four cases tested at diagnosis were negative to the c-ALL antigen and either TdT+ (ALL) or TdT- (AML M1). Maximum survival was less than 8 months. Additional chromosomal change was found at diagnosis in two cases and in relapse in a third. In the case of AML t(4;11) (q21;p15) was present as a second translocation. Additional numerical changes, in these and other reported cases, included + 6, commonly found in ALL, +8, +19, more often reported in AML. It is suggested that additional chromosomal changes in these cases support cytochemical and surface marker evidence that t(4;11) has a pluripotent target cell, similar to that of the Philadelphia translocation.

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Section: Discuss I 0 Nmentioning

confidence: 99%

“…. Additional chromosomal change at diagnosis has occasionally been reported (Morse et ul, 1982;Nagasaka et al, 1983).…”

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confidence: 98%

The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations

Secker-Walker

Stewart

et al. 1985

Br J Haematol

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“…T h e patient described in this report had an acute leukemia that was atypical because the morphology suggested a lymphoid appearance at diagnosis, but both immunophenotypic and morphologic studies indicated a monocytic conversion at relapse. This t( 11; 12) patient had a clinical picture that has been reported in patients who had the t(4; 11) (Nagasaka et al, 1983;Stong et al, 1985). Rearrangements of 12p have been reported in 10% of childhood ALL, particularly at 1 2~1 3 (Krance et al, 1992).…”

Section: Results a N D Discussionmentioning

confidence: 54%

“…T h e most common t(4;ll) is associated with aggressive ALL, but it has also been shown that the cells have the potential to differentiate to a monocytic cell type (Nagasaka et al, 1983;Stong et al, 1985;Pui et al, 1991b). T h e t(9;ll) is seen predominantly in the monocytic or myelomonocytic leukemias (Sandoval et al, 1992), whereas the t( 11; 19) is seen in lymphoid, myeloid, and biphenotypic leukemias (Gibbons et al, 1990;Hudson et al, 1991).…”

Section: Results a N D Discussionmentioning

confidence: 99%

A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene

Sait

Raimondi

Look

et al. 1993

Genes Chromosomes & Cancer

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Translocations involving 11q23 have been shown to be a consistent finding in human hematopoietic malignancies and in some constitutional abnormalities. The identification of a gene, MLL (myeloid/lymphoid or mixed-lineage leukemia), that spans the breakpoints in four different recurrent 11q23 translocations was recently reported. We describe a rare (11;12)(q23;p13) translocation, observed in leukemic cells from a patient with acute lymphoblastic leukemia, which also disrupts this gene.

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“…A translocation (4; 1 l)(q2 1 ;q23) has been associated with a specific subtype of acute leukemia characterized by high leukocyte counts, splenomegaly, and poor prognosis (Oshimura et al, 1977;Van Den Berghe er al., 1979;Prigogina et al, 1979;Third International Workshop on Chromosomes in Leukemia, 1981;Arthur et al, 1982). Recent reports describing ultrastructural, cytochemical and immunologic characteristics of leukemic cells with t(4; 11) have suggested that the disease in these cases represents a proliferation of an early myeloid precursor cell or a multipotent progenitor cell capable of differentiating along myeloid or lymphoid lines (Parkin et al, 1982;Nagasaka et al, 1982;Stong et al, 1985;Mirro et al, 1986).…”

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Unusual cytogenetic findings in two patients with t(4;11) acute leukemia

Testa

Misawa

Pollak

et al. 1986

Intl Journal of Cancer

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Unusual cytogenetic findings are described in two patients with acute leukemia and rearrangements involving chromosomes 4 and 11. Both patients had clinical and phenotypic features often found in leukemia with t(4;11)(q21;q23). At initial diagnosis, one patient showed a standard t(4;11) with duplication of the 4q-translocation derivative. The latter finding has been described previously in a few patients with t(4;11) in association with disease progression. By analogy with the Ph1 chromosome in chronic myelogenous leukemia, duplication of the 4q-suggests that this derivative is the critical recombinant in the t(4;11). The second patient has a novel complex translocation, t(4;11;15)(q21;q23;q21). Analysis of this variant translocation implies that the 11q+ is the consistent chromosome rearrangement in this type of leukemia. The apparent contradiction of the findings in these and other relevant reported cases reviewed here suggests that genes on both the 11q+ and 4q- recombinant chromosomes are important, in either the etiology or the progression of this disease.

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Four cases of t(4;11) acute leukemia and its myelomonocytic nature in infants

Cited by 108 publications

References 21 publications

The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations

The (4;11) translocation in acute leukaemia of childhood: the importance of additional chromosomal aberrations

A t(11;12) 11q23 leukemic breakpoint that disrupts the MLL Gene

Unusual cytogenetic findings in two patients with t(4;11) acute leukemia

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