Four Cases of Mediastinal Lymph Node Carcinoma of Unknown Primary Site After Chemoradiotherapy with a Long Survival

━━ Background. Hilar and/or mediastinal lymph node (LN) cancer without a primary tumor is rare. Case. A 50-year-old man underwent distal gastrectomy for gastric cancer in year X. Although preoperative fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed an LN of 11 mm in diameter with the abnormal uptake of FDG in the subaortic region (LN#5), a biopsy was not requested. In year X＋1, LN#5 shrank to 3 mm, and the carcinoembryonic antigen (CEA) concentration decreased from 56.6 ng/ml to 8.6 ng/ml after gastric cancer surgery. However, the mediastinal LN slowly enlarged from year X＋2, increasing to 24 mm at year X＋ 11; the CEA concentration increased to 1760.4 ng/ml and a nodule appeared in the S 1＋2 segment of the left lung. Surgery was performed. Thoracoscopic resection of LN # 5 and left upper division segmentectomy was performed. The postoperative pathological diagnosis was adenocarcinoma in both the pulmonary nodule and LN#5, and immunostaining was positive for thyroid transcription factor-1 and napsin A. Eleven years later, the primary lesion appeared in the lung and was diagnosed as lung cancer and mediastinal LN metastasis, pT1bN2M0 stage IIIA. Conclusion. Patients with lymph node carcinoma of unknown origin may develop a primary lesion after a long period of time. This case is instructive in suggesting the importance of long-term follow-up in such cases.

show abstract

Primary Tumor Detected 11 Years After the Appearance of Mediastinal Lymph Node Cancer of Unknown Primary

Sogabe

Myobatake

Saito

et al. 2022

JJLC

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Four Cases of Mediastinal Lymph Node Carcinoma of Unknown Primary Site After Chemoradiotherapy with a Long Survival

Cited by 1 publication

References 8 publications

Primary Tumor Detected 11 Years After the Appearance of Mediastinal Lymph Node Cancer of Unknown Primary

Primary Tumor Detected 11 Years After the Appearance of Mediastinal Lymph Node Cancer of Unknown Primary

Contact Info

Product

Resources

About