Abstract:The comparison of protein sequences has been for long a very effective tool in producing biological knowledge. It was initially based on the alignment of sequences, that is to say organizing the set of sequences in columns (of a spreadsheet) of sites which have evolved from a common site of the ancestral sequence. Alignments are generally obtained by minimizing an evolution or an edition cost. Sequence comparisons are now often performed without alignments by comparing the -mer compositions of the sequences. W… Show more
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