FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis

Madarkar, Mahajabeen; Koti, Varsha R

doi:10.5826/dpc.1103a57

Cited by 8 publications

(19 citation statements)

References 9 publications

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“…To analyze the dermoscopic findings in different variants of PCA, we performed a comprehensive search of three medical databases (PubMed, Web of Science, and Scopus) using the search terms ‘dermoscopy’ or ‘dermatoscopy’ combined with ‘primary cutaneous amyloidosis’ or ‘macular amyloidosis’ or ‘lichen amyloidosis’ or ‘nodular amyloidosis’ or ‘biphasic amyloidosis’ or ‘amyloidosis cutis dyschromica’. In total, twelve articles, including three original studies and nine case reports, were identified [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The dermoscopic characteristics of PCA are summarized in Table 1 .…”

Section: Discussionmentioning

confidence: 99%

“…In the majority of cases, LA presented with central white hubs or scar-like centers surrounded by varied pigmentation, mainly in the form of gray-brown dots, globules, or peppering [ 2 , 7 , 11 , 12 ]. Behera et al [ 12 ] coined the term ‘two-zone pattern’ to describe this arrangement of dermoscopic structures.…”

Section: Discussionmentioning

confidence: 99%

“…Behera et al [ 12 ] coined the term ‘two-zone pattern’ to describe this arrangement of dermoscopic structures. Other less frequent findings included shiny white streaks under polarized light, blue-grey ovoid nest-like areas, concentric structures, white scaling, and white collarettes [ 1 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

“…Primary cutaneous amyloidosis (PCA) is a common condition in the Asian and South American populations, characterized by the extracellular deposition of amyloid fibrils in the skin without internal organ involvement [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The disease may be associated with itch and disfigurement, and therefore, it may lead to significant psychological distress [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Dermoscopy of PCA has been the subject of very few studies so far [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. The majority of papers present the dermoscopic features in the Asian and South American populations [ 1 , 2 , 3 , 6 , 8 , 9 , 10 , 11 , 12 ]. As the condition is infrequent in Europe, data on the dermoscopic findings in this population are scarce [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

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Dermoscopic Features of Lichen Amyloidosis in Caucasians—A Case Series and Literature Review

Żychowska¹,

Pięta²,

Rudy³

et al. 2021

Medicina

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Primary cutaneous amyloidosis (PCA) is characterized by the extracellular deposition of amyloid in the skin without systemic involvement. It comprises several clinical variants, the most common of which are macular amyloidosis (MA) and lichen amyloidosis (LA). PCA is frequently observed in Asians, while it is considered to be very rare in Caucasians. In the latter population, the condition often poses a diagnostic challenge. Dermoscopy has already been proved to be a useful, non-invasive diagnostic tool in various non-neoplastic skin diseases. In the paper, we present three Caucasian patients (skin phototypes I–II) with histologically confirmed LA. Under dermoscopy, central white hubs with grayish-brown dots and globules were observed in all three cases. Vascular structures were present in two cases and had the morphology of red globules and thick, unfocused branching lines intersecting the white hubs. A comprehensive review of the literature retrieved twelve papers presenting the dermoscopic features of PCA, including five articles on the dermoscopy of LA. The vast majority of these studies have been conducted on the Asian population, and there is a lack of data on the dermoscopic findings for patients with skin type I or II. The literature review revealed that MA and LA share several dermoscopic similarities (the presence of a white central hub and grayish dots), but also display distinct features. Compared to the dermoscopic features of LA in darker skin phototypes, our patients presented less pronounced pigmentation and more evident vascular structures. Nevertheless, further studies are needed in order to reliably evaluate the dermoscopic features of PCA in various ethnicities.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Dermoscopic Features of Lichen Amyloidosis in Caucasians—A Case Series and Literature Review

Żychowska¹,

Pięta²,

Rudy³

et al. 2021

Medicina

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Dermoscopy aids in differentiating primary cutaneous amyloidosis and post‐inflammatory hyperpigmentation: A clinico‐dermoscopic‐histopathaological study

El-Samanoudy

Gawdat

Fouda

et al. 2022

J of Cosmetic Dermatology

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Background: Primary cutaneous amyloidosis (PCA) and post-inflammatory hyperpigmentation (PIH) are common causes of cutaneous hyperpigmentation that are usually diagnosed clinically. However, their presentations are sometimes atypical, and their differentiation is difficult. Dermoscopy is a valuable diagnostic tool for pigmented diseases that might aid in their diagnosis.Objective: To describe the characteristic dermoscopic features of PCA and PIH together with histopathological correlation, and to differentiate between these conditions in a non-invasive way.Methods: Fifty-two patients with PCA (n = 26) and PIH (n = 26) were enrolled. A detailed history, skin examination, dermoscopic examination using handheld and video dermoscopy, and histopathological evaluation were performed. Results:A statistically significant difference could be detected between PCA and PIH in terms of the duration of the disease (p = 0.027), symmetry (p = 0.044), rippling (p < 0.001), and back affection (p = 0.048). On dermoscopic examination, central hubs were seen more in the PCA group (p < 0.001) with different patterns of peripheral pigmentation. Histopathologically, the number of melanophages per high-power field was significantly higher in the PCA group (p = 0.013). Conclusion:The results of this study shed the light on the potential of dermoscopy as a non-invasive diagnostic tool in differentiating between doubtful cases of PCA and PIH.

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Clinical Characteristics and Treatment of Acne with Sensitive Skin

Sheng,

Zhou,

et al. 2023

Dermatologic Therapy

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Background. Acne is a prevalent skin disorder that primarily affects seborrheic areas. It occurs due to hair follicle obstruction and subsequent inflammation. Patients with acne often exhibit compromised skin barrier function and sensitivity, making treatment challenging. Objectives. This study aimed to investigate the occurrence of acne complicated by sensitive skin and explore the associated physiological changes. Methods. The lactic acid test and capsaicin test were employed to identify subjects with simple acne and those with acne and sensitive skin. Physiological characteristics were assessed in both groups. Two random groups were selected from the subjects with acne and sensitive skin. One group received treatment for acne alone, while the other group received combined treatment for acne and sensitive skin care. The efficacy and physiological function of the two groups were compared after treatment. Results. Among 170 acne patients, 99 were identified as having acne with sensitive skin. Patients with acne and sensitive skin exhibited significantly higher scores on the lactic acid test and capsaicin test compared to those with simple acne. They also showed increased transepidermal water loss (TEWL), decreased skin cuticle hydration (SCH), thinner epidermis, and thicker blood vessels. The group receiving combined treatment demonstrated a more significant reduction in the number of skin lesions and IGA scores compared to the group receiving treatment for acne alone. They also exhibited lower scores on the lactate and capsaicin tests, along with decreases in TEWL and increases in SCH. Conclusions. Acne with sensitive skin is highly prevalent and is associated with distinct physiological characteristics. Combined treatment targeting both acne and sensitive skin yields excellent clinical outcomes and improves skin’s physiological function. These findings underscore the importance of considering sensitive skin in the clinical management of acne.

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FotoFinder Dermoscopy Analysis and Histopathological Correlation in Primary Localized Cutaneous Amyloidosis

Cited by 8 publications

References 9 publications

Dermoscopic Features of Lichen Amyloidosis in Caucasians—A Case Series and Literature Review

Dermoscopic Features of Lichen Amyloidosis in Caucasians—A Case Series and Literature Review

Dermoscopy aids in differentiating primary cutaneous amyloidosis and post‐inflammatory hyperpigmentation: A clinico‐dermoscopic‐histopathaological study

Clinical Characteristics and Treatment of Acne with Sensitive Skin

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