Fosfomycin Use in Multi Drug Resistant Uropathogenic &lt;i&gt;Escherichia coli&lt;/i&gt;

Mittal, Sakshi; Sharma, Madhu; Chaudhary, Uma

doi:10.2174/1871526515666150916141907

Cited by 8 publications

(6 citation statements)

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“…[12] In another study by Mittal et al ., it was found that fosfomycin was 100% sensitive to uropathogenic E. coli strains. [13] In this present study, 95.18% isolates were susceptible to fosfomycin which is similar to the findings of a study done by Sabharwal and Sharma where it was found that 94.4% of the isolates causing UTI were susceptible to fosfomycin. [14] Khawaja et al .…”

Section: Discussionsupporting

confidence: 90%

Fosfomycin susceptibility among multidrug-resistant, extended-spectrum beta-lactamase-producing, carbapenem-resistant uropathogens

2017

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Introduction:Urinary tract infection (UTI) is one of the most common infectious diseases. With the emergence of multidrug resistance (MDR), therapeutic options for treatment of UTIs are becoming limited. Fosfomycin has emerged as a novel oral therapeutic option with bactericidal activity against the MDR uropathogens. We evaluated the susceptibility pattern of uropathogens to this antibiotic.Methods:A prospective study was conducted for 6 months in a tertiary care hospital in Eastern India to evaluate whether the common uropathogens were susceptible to fosfomycin. Identification of organisms causing significant bacteriuria was done by conventional biochemical and VITEK 2 Compact System™. Antimicrobial susceptibility testing was performed against these pathogens by Kirby-Bauer disc diffusion method. Minimum inhibitory concentrations were measured for certain drugs by E-strips and VITEK 2 Compact System.Results:A total of 2229 urine samples were referred for culture during the study period, which yielded 356 significant bacterial isolates. Among these isolates, 64.78% were extended-spectrum beta-lactamases producers, 15.97% were carbapenem-resistant Enterobacteriaceae, and 42.7% isolates were found to be MDR Enterobacteriaceae (MDRE). However, 95.18% of the total isolates and 95.93% of MDRE were found to be susceptible to fosfomycin.Conclusion:The common uropathogens, including MDR isolates, show high in vitro susceptibility to fosfomycin, which therefore has the potential to emerge as a promising alternative oral agent for outpatient therapy of UTIs.

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Section: Discussionsupporting

confidence: 90%

Fosfomycin susceptibility among multidrug-resistant, extended-spectrum beta-lactamase-producing, carbapenem-resistant uropathogens

2017

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“…[14,15] As CLSI does not mention the zone size for Klebsiella sp and Pseudomonas sp, values were interpreted with respect to CLSI interpretative criteria for E. coli. The sensitivity of E coli and Klebsiella sp was more when compared to study done by Zafar et al [13] Same study reports sensitivity of Psudomonas sp to 100% whereas in this study the sensitivity is 41-50%. Review literature suggest inherent and acquired resistant mechanism for Pseudomonas sp which could be responsible forits low sensitivity.…”

Section: Discussioncontrasting

confidence: 56%

“…Similiar to other studies ;E coli is the most common isolate in both the locations in urinary tract infection in this study followed by Klebsiella sp and Pseudomonas. [13] The sensitivity to fosfomycin in E coli isolates was less when compared to other study 85% in OPD isolates and 79% in IPD isolates. [14,15] As CLSI does not mention the zone size for Klebsiella sp and Pseudomonas sp, values were interpreted with respect to CLSI interpretative criteria for E. coli.…”

Section: Discussionmentioning

confidence: 60%

Fosphomycin: Current Scenario and Susceptibility Pattern in Urinary Isolates of a Teaching Hospital

Ah¹

2018

jmscr

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“…60% women will develop an episode of UTIs in their lives and one third of those will have a recurrence within a year. 6 UTIs during pregnancy must be effectively treated to prevent complications associated with it like pyelonephritis, preterm rupture of membrane, preterm labour, chorio-amnionitis, and neonatal septicemia. Repeated urinary tract infection and its treatment with long courses of antibiotic treatment resulted in highly antibiotic resistant bacteria and multi-drug resistant organisms.…”

Section: Discussionmentioning

confidence: 99%

To compare empirical treatment of uncomplicated UTI in pregnancy

2020

IJOGR

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Objectives: To compare empirical treatment with fosfomycin and nitrofurantoin in uncomplicated lower urinary tract infection during pregnancy. Materials and Methods: Patients were recruited from OPD of obstetrics and gynecology presenting with symptoms of lower (UTIs) urinary tract infection. Patients were divided randomly alternately in two groups. Fosfomycin therapy was given in group 1 (n=60) and seven days nitrofurantoin therapy was given in group 2(n=60). Patients were evaluated for symptoms improvement, compliance, side effects and cost of treatment. Results: Efficacy of fosfomycin on day 7 post treatment is 98% compare to nitrofrantoin I s83.3%. Side effect is 15% in fosfomycin group as compare to 28.3% in nitrofurantoin group. Compliance is 100% in fosfomycin group as compare to 96.6% in nitrofrantoin group. Cost of therapy in fosfomycin group is 300 Rs average while 170 Rs in nitrofurantoin group. Conclusion: Fosfomycin is first line empirical treatment of uncomplicated UTIs during pregnancy because it is safe, effective, less resistance, higher patient's compliance with fewer side effect and equal cost of therapy.

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Fosfomycin Use in Multi Drug Resistant Uropathogenic <i>Escherichia coli</i>

Abstract: The testing of the newer therapeutic agents like fosfomycin will add on to therapeutics for UTI's.

Cited by 8 publications

References 0 publications

Fosfomycin susceptibility among multidrug-resistant, extended-spectrum beta-lactamase-producing, carbapenem-resistant uropathogens

Fosfomycin susceptibility among multidrug-resistant, extended-spectrum beta-lactamase-producing, carbapenem-resistant uropathogens

Fosphomycin: Current Scenario and Susceptibility Pattern in Urinary Isolates of a Teaching Hospital

To compare empirical treatment of uncomplicated UTI in pregnancy

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