“…A single 3 g dose of fosfomycin was compared with single doses of amoxicillin 3 g, 188,189 ofloxacin 200 mg, 190 norfloxacin 800 mg, 191 pefloxacin 800 mg, 192 trimethoprim 200 mg, 193 and cotrimoxazole 1920 mg. 190 A single dose of fosfomycin was also compared with amoxicillin + clavulanic acid 375 mg four times daily for five days, 194 cefalexin 500 mg four times daily for five days, 195 ciprofloxacin 500 mg twice daily for five days, 196 pipemidic acid 400 mg twice daily for 5-7 days, [197][198][199] norfloxacin 400 mg bid for 5-7 days, 197,[200][201][202][203] cotrimoxazole 480 mg twice daily for three days, 204 trimethoprim 200 mg twice daily for five days, 18 and nitrofurantoin 50 mg four times daily for seven days. 205 In these studies, the microbiological and clinical efficacies were similar, and 70%-95% microbial eradication rates were observed 5-11 days after treatment.…”