Fos Immunoreactivity in the Suprachiasmatic Nuclei of Golden Hamsters Bearing an Ectopic Pituitary Graft

Cutrera, Rodolfo A.; Boggio, Verónica; Castrillón, Patricia O.; Scacchi, Pablo; Esquifino, Ana I.; Cardinali, Daniel P.

doi:10.1159/000065055

Cited by 2 publications

(1 citation statement)

References 38 publications

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“…Given the imbalance of the hypothalamic-pituitary axis present in hyperprolactinemia, it could affect the circadian timing system on several levels. Physiological and experimentally-induced hyperprolactinemia in rats was associated with modifications of Fos expression in the SCN (Cutrera et al, 2002;Lee et al, 1998). Thus, hyperprolactinemia might alter the metabolic activity of the central component of the circadian rhythm system.…”

Section: Discussionmentioning

confidence: 97%

Dysregulation of Circadian Rhythms Following Prolactin‐Secreting Pituitary Microadenoma

Borodkin

Ayalon

Kanety

et al. 2005

Chronobiology International

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A patient who developed an irregular sleep-wake pattern following prolactin-secreting pituitary microadenoma is described. The patient reported difficulties in sleep onset and awakening at the desired time, which caused major dysfunction in his daily life activities. Despite these difficulties, the sleep-related complaints of the patient remained unrecognized for as long as three yrs. Statistical analyses of the patient's rest-activity patterns revealed that the disruption of the sleep-wake circadian rhythm originated from a disharmony between ultradian (semicircadian) and circadian components. The circadian component displayed shorter than 24 h periodicity most of the time, but the semicircadian component fluctuated between longer and shorter than 12 h periods. Additionally, desynchrony in terms of period length was found in the tentative analyses of the rest-activity pattern, salivary melatonin, and oral temperature. While the salivary melatonin time series data could be characterized by a best-fit cosine curve of 24 h, the time series data of oral temperature was more compatible with 28 h best-fit curve. The rest-activity cycle during the simultaneous measurements, however, was best approximated by a best-fit curve of 21 h. The dysregulation of circadian rhythms occurred concomitantly, but not beforehand, with the onset of pituitary disease, thus suggesting an association between the two phenomena. This association may have interesting implications to the modeling of the circadian time-keeping system. This case also highlights the need to raise the awareness to circadian rhythm sleep disorders and to consider disruptions of sleep-wake cycle in patients with pituitary adenoma.

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Section: Discussionmentioning

confidence: 97%

Dysregulation of Circadian Rhythms Following Prolactin‐Secreting Pituitary Microadenoma

Borodkin

Ayalon

Kanety

et al. 2005

Chronobiology International

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Daily Changes of GABA and Taurine Concentrations in Various Hypothalamic Areas Are Affected by Chronic Hyperprolactinemia

Duvilanski

Álvarez

Castrillón

et al. 2003

Chronobiology International

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This study was designed to characterize, in anterior, mediobasal, and posterior hypothalamic and median eminence, the 24h changes of gamma aminobutyric acid (GABA) and taurine (TAU) contents in adult male rats and to analyze whether chronic hyperprolactinemia may affect these patterns. Rats were turned hyperprolactinemic by a pituitary graft. Plasma prolactin (PRL) levels increased after pituitary grafting at all time points examined. A disruption of the circadian rhythm was observed in pituitary-grafted rats, whereas GABA and TAU content followed daily rhythms in all areas studied in controls. In the mediobasal hypothalamus, two peaks for each amino acid were found at midnight and midday. In the anterior hypothalamus, GABA and TAU showed only one peak of concentration at midnight. In the posterior hypothalamus, the values of both GABA and TAU were higher during the light as compared to the dark phase of the photoperiod. In the median eminence GABA content peaked at 20:00h, the time when TAU exhibited the lowest values. Hyperprolactinemia abolished the 24h changes of GABA in the mediobasal hypothalamus and reduced its content as compared to controls. Hyperprolactinemia advanced the diurnal peak of TAU to 12:00h in the mediobasal hypothalamus and did not modify the 24:00h peak. In the anterior hypothalamus, hyperprolactinemia increased GABA and TAU contents during the light phase while it decreased them during the dark phase of the photoperiod. In the posterior hypothalamus hyperprolactinemia did not modify GABA or TAU patterns as compared to controls. In the median eminence hyperprolactinemia increased the 20:00h peak of GABA and shift advanced the decrease in TAU content at 20:00h and its maximum at 24:00h as compared to controls. These data show that GABA and TAU content exhibit specific daily patterns in each hypothalamic region studied. PRL differentially affects the daily pattern of these amino acids in each hypothalamic region analyzed.

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Fos Immunoreactivity in the Suprachiasmatic Nuclei of Golden Hamsters Bearing an Ectopic Pituitary Graft

Cited by 2 publications

References 38 publications

Dysregulation of Circadian Rhythms Following Prolactin‐Secreting Pituitary Microadenoma

Dysregulation of Circadian Rhythms Following Prolactin‐Secreting Pituitary Microadenoma

Daily Changes of GABA and Taurine Concentrations in Various Hypothalamic Areas Are Affected by Chronic Hyperprolactinemia

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