Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison

Coolen, Lique M.; Peters, Hans J.P.W.; Veening, Jan G.

doi:10.1016/0006-8993(96)00763-9

Cited by 245 publications

(157 citation statements)

References 41 publications

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“…Similar results were observed in rats, with continuously increasing activity during mating, until after EJAC, when activity decreased during the postejaculatory interval (PEI) (Shimura et al, 1994). Similarly, sexual activity increased Fos immunoreactivity (-ir), a measure of cellular activity, in the MPOA of male rats (Baum and Everitt, 1992;Bressler and Baum, 1996;Coolen et al, 1996; for review, see Pfaus and Heeb, 1997), hamsters (Kollack-Walker and Newman, 1997), gerbils (Heeb and Yahr, 1996), and musk shrews (Gill et al, 1998). These data support the conclusion that neural activity in the MPOA is important for male sexual behavior.…”

Section: Introductionsupporting

confidence: 67%

Preoptic Glutamate Facilitates Male Sexual Behavior

2006

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The medial preoptic area (MPOA) is a critical regulatory site for the control of male sexual behavior. We first measured glutamate in 2 min microdialysate samples from the MPOA before, during, and after copulation by male rats. There was a slight [ϳ140% of baseline (BL)] rise in extracellular glutamate when the female was presented, a significant increase (ϳ170% of BL) during periods of mounting and intromitting, and a very large increase in samples collected during ejaculation (ϳ300% of BL). A precipitous fall in levels occurred in the first postejaculatory sample; the magnitude of this fall was highly correlated with the length of the postejaculatory interval of quiescence. In experiment 2, we reverse-dialyzed a mixture of glutamate uptake inhibitors into the MPOA before and during mating; control animals received artificial CSF. The mixture increased extracellular glutamate (ϳ280% of BL), increased the number of ejaculations in the 40 min test, decreased ejaculation latency, and decreased the postejaculatory latency to resume copulation. These data, together with other findings that glutamate in the MPOA can elicit genital reflexes in anesthetized rats and that glutamate receptor antagonists in the MPOA impair copulation, strongly suggest that MPOA glutamate is a major facilitator of copulation and that the postejaculatory fall in glutamate regulates the postejaculatory interval.

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Section: Introductionsupporting

confidence: 67%

Preoptic Glutamate Facilitates Male Sexual Behavior

2006

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“…Noncontact erections and exposure to the bedding of an estrous female also induced Fos-ir in the MPOA of male rats, but the effects were less dramatic than those observed following copulation [48]. In one subregion, the posterodorsal preoptic nucleus, Fos-ir was significantly increased only following ejaculation in male rats [49], hamsters [46] and gerbils [47], again suggesting that subregions within the MPOA may play different roles in regulating copulation.…”

Section: Measuring Mating-induced Activity In the Mpoamentioning

confidence: 91%

Dopamine, the medial preoptic area, and male sexual behavior

Domínguez

Hull

2005

Physiology & Behavior

248

190

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“…Conversely, a large number of studies in a variety of species indicate that stereotaxic implants of testosterone in the mPOA activate most if not all aspects of male copulatory behavior [32,80]. The implication of the mPOA in the control of male sexual behavior is also attested by experiments demonstrating that performance of this behavior increases neuronal activity in this brain region as assessed by an increase in 2-deoxyglucose incorporation [60], cytochrome oxidase activity [122] or increased transcription of immediate early genes such as c-fos or egr-1 (also know as Zenk in the avian literature) [49,56,76,93,118,134,153].…”

Section: The Preoptic Area As An Integration Center For the Control Omentioning

confidence: 95%

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

Balthazart

Ball

2007

Frontiers in Neuroendocrinology

191

168

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Several studies have suggested dissociations between neural circuits underlying the expression of appetitive (i.e. sexual motivation) and consummatory components (i.e., copulatory behavior) of vertebrate male sexual behavior. The medial preoptic area (mPOA) clearly controls the expression of male copulation but, according to a number of experiments, is not necessarily implicated in the expression of appetitive sexual behavior. In rats for example, lesions to the mPOA eliminate maletypical copulatory behavior but have more subtle or no obvious effects on measures of sexual motivation. Rats with such lesions still pursue and attempt to mount females. They also acquire and perform learned instrumental responses to gain access to females. However, recent lesions studies and measures of the expression of the immediate early gene c-fos demonstrate that, in quail, subregions of the mPOA, in particular of its sexually dimorphic component the medial preoptic nucleus, can be specifically linked with either the expression of appetitive or consummatory sexual behavior. In particular more rostral regions can be linked to appetitive components while more caudal regions are involved in consummatory behavior. This functional sub-region variation is associated with neurochemical and hodological specializations (i.e. differences in chemical phenotype of the cells or in their connectivity), especially those related to the actions of androgens in relation to the activation of male sexual behavior, that are also present in rodents and other species. It could thus reflect general principles about POA organization and function in the vertebrate brain.

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Fos immunoreactivity in the rat brain following consummatory elements of sexual behavior: a sex comparison

Abstract: Please be advised that this information was generated on 2018-05-12 and may be subject to change. BRAIN RESEARCH

Cited by 245 publications

References 41 publications

Preoptic Glutamate Facilitates Male Sexual Behavior

Preoptic Glutamate Facilitates Male Sexual Behavior

Dopamine, the medial preoptic area, and male sexual behavior

Topography in the preoptic region: Differential regulation of appetitive and consummatory male sexual behaviors

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