“…In this regard, this result opens new insights in the field of psychiatric research. First, it should substantially enhance our understanding of the biology of mania, manic depressive illness, aggression, and suicidal behavior, which are all markedly affected by lithium; and, second, it should facilitate development of alternative treatment or elaboration of novel promising therapeutic agents, because lithium is a very valuable drug, but one with substantial side-effects and a very low therapeutic safety index (Schildkraut 1973;Schou and Thomsen 1975;Wood and Goodwin 1987;Price et al 1990;Odagaki et al 1992;Price and Heninger 1994;Schou 1997;Gershon and Soares 1997;Soares and Gershon 1998).…”