Forty-year-old diabetic lady with tightness in lower limbs

Khade, Snehaldatta S; Deshmukh, Shrikant S; Dhonde, Pramod; Khadilkar, Satish V

doi:10.4103/0972-2327.93269

Cited by 3 publications

(2 citation statements)

References 12 publications

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“… 10–12 Episodic migraine disorder involving sensory sensitivity has widespread influence on the central nervous system and related organs; changes in the synchronisation of cortical activity may be an explanation of its pathophysiology. 13 Recent migraine research has focused on small molecules, calcitonin gene-related peptide (CGRP), substance P and endothelin. 6 14 In fact, the interaction between these neuropeptides and CKD is mediated by vasoafferent nerve activation, given the fact that the initial insult could activate renal sympathoexcitation.…”

Section: Introductionmentioning

confidence: 99%

Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study

Weng

Kor

et al. 2017

BMJ Open

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ObjectiveWe compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.DesignPopulation-based cohort study.Setting8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database.ParticipantsFinally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measureWe used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.ResultsThe incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40–64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1–2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.ConclusionMigraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine.

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Section: Introductionmentioning

confidence: 99%

Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study

Weng

Kor

et al. 2017

BMJ Open

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“…A study by Patel et al similarly reported that the odds of having migraine attacks were higher among vitamin D deficiency (OR: 1.97%; p<0.0001) and hypocalcemia (OR: 1.11; p=0.0061) patients [8]. The possible explanation of this association between migraine and Vitamin D deficiency and hypocalcemia can be neurogenic inflammation involved with the migraine cascade of events [26, 27] and the role of vitamin D in increasing the inflammation and the observed phenomenon of neuronal hyperexcitability in hypocalcemia leading to increased severity of the migraine attacks [28].…”

Section: Discussionmentioning

confidence: 99%

A Comprehensive Assessment of Vascular and Nonvascular Risk Factors Associated with Migraine

Patel¹,

Shah²,

Malik³

et al. 2019

Cureus

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Introduction: Migraine is a chronic disabling neurological disease, with an estimated expense of $15-20 million/year. Several studies with a small number of patients have studied risk factors for migraine such as cardiovascular disorders, stroke, smoking, demographic, and genetic factors but this is the first comprehensive study for evaluation of vascular and nonvascular risk factors. It is important to evaluate all the risk factors that help to prevent the healthcare burden related to migraine. Methodology: We performed a retrospective cross-sectional analysis of the Nationwide Inpatient Sample (NIS) (years 2013-2014) in adult (>18-years old) hospitalizations in the United States. Migraine patients were identified using ICD-9-CM code to determine the demographic characteristics, vascular, and nonvascular risk factors. Univariate analysis was performed using the chi-square test and a multivariate survey logistic regression analysis was performed to identify the prevalence of the risk factors and evaluate the odds of prevalence of risk factors amongst migraine patients compared to nonmigraine patients, respectively. Results: On weighted analysis, after removing missing data of age, gender and race, from years 2013 to 2014, of the total 983,065 (1.74%) migraine patients were identified. We found that younger (median age 48-years vs. 60-years), female (82.1% vs. 58.5%; p<0.0001), white population (76.8% vs. 70.5%; p<0.0001), and privately insured (41.1% vs. 27.4%; p<0.0001) patients were more likely to have migraine than others. Cerebral atherosclerosis, diabetes mellitus, ischemic heart disease, atrial fibrillation, and alcohol abuse were not significantly associated with migraine. Migraineurs had higher odds of having hypertension [odds ratio (OR):

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‘Mini-boomerang sign’: reversible corpus callosal signal change in neuroleptospirosis

Khanra

Talukdar

2013

International Journal of Infectious Diseases

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Medical Imagery'Mini-boomerang sign': reversible corpus callosal signal change in neuroleptospirosis A 30-year-old male presented with a high-grade fever of 7-day duration, followed by acute onset confusion and poor verbal fluency. Conjunctival hemorrhage and signs of meningeal irritation were noted. Moderate leukocytosis, thrombocytopenia, and elevated alkaline phosphatase and creatinine phosphokinase with normal renal function were found. The cerebrospinal fluid was culture-negative. The serum anti-Leptospira IgM antibody level was 87 U/ml (cut-off <15 U/ml). Magnetic resonance imaging (MRI) of the brain (Figure 1) showed a hyperintense area involving the central part of the splenium of the corpus callosum (SCC), with decreased apparent diffusion coefficient (ADC) values. The patient

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Forty-year-old diabetic lady with tightness in lower limbs

Cited by 3 publications

References 12 publications

Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study

Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study

A Comprehensive Assessment of Vascular and Nonvascular Risk Factors Associated with Migraine

‘Mini-boomerang sign’: reversible corpus callosal signal change in neuroleptospirosis

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