Forty-Five Years of Research and Progress in Breast Cancer: Progress for Some, Disparities for Most

Hoxha, Ilir; Islami, Dafina Ademi; Uwizeye, Glorieuse; Forbes, Victoria; Chamberlin, Mary D.

doi:10.1200/go.21.00424

Cited by 7 publications

(7 citation statements)

References 30 publications

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“…In the case of breast cancer, there is widespread evidence of insufficient decision-making that is not based on best medical practice standards and inappropriate treatment and follow-up by providers and patients [ 23 ]. The surgical treatments for breast cancer have changed dramatically, from radical mastectomy to breast-conserving surgery [ 83 ]. About one-third of women with breast cancer in Kosovo still have a mastectomy [ 73 ].…”

Section: Resultsmentioning

confidence: 99%

“…It confirms many publicly known facts about the management of NCDs that are valid for most of the healthcare provided in the country. For example, studies have reported that the system is underfunded, [ 4 , 11 , 87 ] care availability is limited in quality and quantity, [ 4 , 83 ] issues exist relating to availability and impact of the application of clinical standards [ 4 , 15 , 84 ], and there are issues with supply with the workforce [ 11 , 88 ]. This review highlights the issues with a defragmented system of provision of NCD care, as well as efforts in the function of improvement of the existing situation.…”

Section: Discussionmentioning

confidence: 99%

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Management of Non-Communicable Diseases in Kosovo: A Scoping Review

Hoxha

Apuk

Kryeziu

et al. 2023

IJERPH

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Background—Non-communicable diseases (NCDs) affect a growing share of the population in Kosovo. The country faces challenges with NCDs management, specifically detecting, screening, and treating people with NCDs. Objective—To assess the management of NCDs, including the inputs that influence the provision of NCDs and outcomes of NCD management. Eligibility criteria—Studies had to report NCD management in Kosovo. Sources of evidence—We systematically searched Google Scholar, PubMed, Scopus, and Web of Science. Charting methods—The data were charted by two researchers. In addition, we extracted data on general study details and design and information on the management and outcomes of NCDs in Kosovo. Synthesis of results—For the mix of studies that were included in the review, thematic narrative synthesis was used. We developed a conceptual framework based on health production core components to analyze the data. Results—Kosovo’s health care system is available to provide basic care for patients with NCDs. However, there are serious limitations in the availability of key inputs providing care, i.e., funding, medicines, supplies, and medical staff. Additionally, in terms of the management of NCDs, there are areas for improvement, such as limited application of clinical pathways and guidelines and issues with referrals of patients among levels and sectors of care. Finally, it is worth noting that there is overall limited information on NCD management and outcomes. Conclusions—Kosovo provides only basic services and treatment of NCDs. The data reporting the existing situation on NCD management are limited. The inputs from this review are helpful for existing policy efforts by the government aimed to enhance NCD care in Kosovo. Funding—This study was funded by World Bank Grant. WeBa NCD Trust Fund (P170638).

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Management of Non-Communicable Diseases in Kosovo: A Scoping Review

Hoxha

Apuk

Kryeziu

et al. 2023

IJERPH

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“…Cancer‐related cognitive impairment (CRCI) is an increasing issue in cancer survivors, especially in older survivors 1 . Recent advancements in cancer treatment, such as targeted therapies, immunotherapy, and endocrine therapy, have improved breast cancer survival 2,3 . CRCI has been reported in cancer survivors, which affects their quality of life 4 .…”

Section: Introductionmentioning

confidence: 99%

“… 1 Recent advancements in cancer treatment, such as targeted therapies, immunotherapy, and endocrine therapy, have improved breast cancer survival. 2 , 3 CRCI has been reported in cancer survivors, which affects their quality of life. 4 Older survivors may have persistent CRCI, particularly in attention, processing speed, working memory, and executive function, even several years after treatment.…”

Section: Introductionmentioning

confidence: 99%

Brain white matter microstructural changes in chemotherapy‐treated older long‐term breast cancer survivors

Daniel,

Deng,

Patel

et al. 2023

Cancer Medicine

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PurposeTo assess white matter microstructural changes in older long‐term breast cancer survivors 5–15 years post‐chemotherapy treatment.MethodsBreast cancer survivors aged 65 years or older who underwent chemotherapy (C+) and who did not undergo chemotherapy (C−) and age‐ and sex‐matched healthy controls (HC) were enrolled at time point 1 (TP1) and followed for 2 years for time point 2 (TP2). All participants underwent brain MRI with diffusion tensor images and neuropsychological (NP) testing with the NIH Toolbox Cognition Battery. Tract‐based spatial statistics (TBSS) analysis was performed on the diffusion tensor images to assess white matter microstructural changes with the fractional anisotropy (FA) parameter.ResultsThere were significant longitudinal alterations in FA within the C+ group over time. The C+ group showed diminished FA in the body and genu of corpus callosum, anterior corona radiate, and external capsule on both the whole brain and region of interest (ROI) based analyses after p < 0.05 family‐wise error (FWE) correction. However, there were no significant group differences between the groups at TP1. Additionally, at TP1, a positive correlation (R = 0.58, p = 0.04) was observed between the FA value of the anterior corona radiata and the crystallized composite score in the C+ group.ConclusionsBrain white matter microstructural alterations may be the underlying neural correlates of cognitive changes in older breast cancer survivors who had chemotherapy treatment years ago.

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“…Therefore, efforts to promote early diagnosis are still a primary focus of fighting breast cancer. Early diagnosis is associated with reduced mortality, and long intervals between breast cancer detection and treatment initiation can impact the prognosis of the disease (Hoxha et al, 2022). Therefore, it is essential to minimize delays in disease detection and diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Psychological characteristics of women with breast cancer who have applied for specialized medical care late

Ponomareva¹,

Pakhomova²,

Tsiring³

2022

Rev. Invest. Univ. Quindío

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Long intervals between detecting breast cancer and the beginning of treatment can influence the prognosis of the course of the disease and survival. This research aims to reveal the psychological characteristics of women with breast cancer who applied for specialized medical care late after detecting a mass lesion in the breast. The methods used in the study were a questionnaire, a test method, and methods of mathematical data processing. The Analysis of Variance (ANOVA) method was used as a method of mathematical statistics. The study involved 149 women aged 32 to 80 years (mean age 55 years) with breast cancer of different stages under the care of an oncologist from the time of diagnosis up to 6 months, living in Chelyabinsk city and Chelyabinsk region, Russia, who took part in the study in 2019-2021. Based on empirical research, it was found that women who delayed contacting their doctor to diagnose and initiate treatment of breast cancer had a more positive worldview, a more diverse repertoire of coping strategies, expressed motivational and cognitive components of personal helplessness, and an internal locus of control, compared to women who addressed their physician at the first signs of breast cancer.

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Forty-Five Years of Research and Progress in Breast Cancer: Progress for Some, Disparities for Most

Abstract: Gains in Breast Cancer Treatment Unavailable for MostAuthor affiliations and support information (if applicable) appear at the end of this article.

Cited by 7 publications

References 30 publications

Management of Non-Communicable Diseases in Kosovo: A Scoping Review

Management of Non-Communicable Diseases in Kosovo: A Scoping Review

Brain white matter microstructural changes in chemotherapy‐treated older long‐term breast cancer survivors

Psychological characteristics of women with breast cancer who have applied for specialized medical care late

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