Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults

Biancuzzo, Rachael M.; Young, Albert G.; Bibuld, Douglass; Cai, Mona H; Winter, Michael; Klein, Ellen; Ameri, Allen; Reitz, Richard E.; Salameh, Wael A.; Chen, Thomas; Holick, Michael F.

doi:10.3945/ajcn.2009.27972

Cited by 160 publications

(159 citation statements)

References 45 publications

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“…The studies were conducted in the United States, Canada, United Kingdom, Australia, Denmark, and Italy; all studies were single-center studies. Seven studies were conducted in healthy, free-living participants (4,6,7,12,13,15,17); one study focused on elderly women who were residents of a nursing home and were deficient in vitamin D (5), whereas another study instead focused on hospital inpatients who had been diagnosed with a hip fracture and were vitamin D deficient (16). The final study recruited participants who were under the care of a rheumatology outpatient clinic (diagnosis unspecified) and were vitamin D insufficient (14).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Only 4 studies used a control or placebo group to compare against intervention groups (4,6,7,13), and of those, only 3 studies implemented double blinding of the intervention (4, 6, 7). Of the 6 studies that chose not to compare intervention groups against a control group (5, 12, 14-17), 3 studies were double blind to the intervention (12,15,16).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

Tripkovic¹,

Lambert²,

Hart³

et al. 2012

SciVee

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Conclusions: This meta-analysis indicates that vitamin D 3 is more efficacious at raising serum 25(OH)D concentrations than is vitamin D 2 , and thus vitamin D 3 could potentially become the preferred choice for supplementation. However, additional research is required to examine the metabolic pathways involved in oral and intramuscular administration of vitamin D and the effects across age, sex, and ethnicity, which this review was unable to verify.Am J Clin Nutr 2012;95:1357-64.

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

Tripkovic¹,

Lambert²,

Hart³

et al. 2012

SciVee

117

134

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show abstract

“…Moreover, few foods contain vitamin D in noteworthy concentrations; those that do are fish-liver oils, fatty fish and egg yolk. Furthermore, there is a wide variety of foods fortified with vitamin D across the world (Calvo et al, 2005), that is, dairy products, bread, and recently, orange juice (Biancuzzo et al, 2010;Holick et al, 1992;Natri et al, 2006). Naturally, the vitamin D 2 content of cultivated mushrooms is almost nil (o0.1 mg/100 g fresh weight) yet they are very rich in ergosterol (Jasinghe and Perera, 2005;Mattila et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Bioavailability of vitamin D2 from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial

et al. 2011

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Background/Objectives: Mushrooms contain very little or any vitamin D 2 but are abundant in ergosterol, which can be converted into vitamin D 2 by ultraviolet (UV) irradiation. Our objective was to investigate the bioavailability of vitamin D 2 from vitamin D 2 -enhanced mushrooms by UV-B in humans, and comparing it with a vitamin D 2 supplement. Subjects/Methods: Fresh mushrooms were irradiated with an UV-B dose of 1.5 J/cm 2 , increasing vitamin D 2 content from o1 to 491 mg/100 g and made to an experimental soup. In this 5-week, single-blinded, randomized, placebo-controlled trial, 26 young subjects with serum 25-hydroxyvitamin D (25OHD) p50 nmol/l were randomly assigned into three groups ((a) mushroom, (b) supplement and (c) placebo). They received during winter (a) 28 000 IU (700 mg) vitamin D 2 via the experimental soup, or (b) 28 000 IU vitamin D 2 via a supplement or (c) placebo, respectively. Results: After 2 weeks, serum 25OHD was significantly higher in the mushroom than in the placebo group (P ¼ 0.001). The serum 25OHD concentrations in the mushroom and supplement groups rose significantly and similarly over the study period by 3.9 nmol/l (95% confidence interval (95% CI): 2.9, 4.8) and by 4.7 nmol/l per week (95% CI: 3.8, 5.7), respectively. Conclusions: We are the first to demonstrate in humans that the bioavailability of vitamin D 2 from vitamin D 2 -enhanced button mushrooms via UV-B irradiation was effective in improving vitamin D status and not different to a vitamin D 2 supplement. This trial was registered at http://germanctr.de as DRKS00000195.

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“…Vitamin D (D2, D3, or both) deficiency is an international health concern that has been associated with rickets, osteomalacia, muscle weakness, osteoporosis, and an increased risk of wheezing diseases, autoimmune diseases (eg, type 1 diabetes, multiple sclerosis, rheumatoid arthritis, and Crohns disease), and cancer, such as of the prostate, breast, and colon [10]. Vitamin D has been demonstrated as having potential immunomodulatory activity; vitamin D analogues are effective in the treatment of psoriasis [11].…”

Section: Introductionmentioning

confidence: 99%

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

Faruk¹,

Yousef²,

Mohamed³

2014

J Histol Histopathol

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Background: Nasal polyps (NPs) are benign pedicled mucosal protrusions into the nasal cavity of multifactorial origin. Vitamin D has been demonstrated as having potential immunomodulatory activity and act as an antiproliferative agents. Aim of the work: To determine the possible antiproliferative effect and immunomodulatory activity of VD on human nasal polyposis. Material and methods: Based on thirty patients and divided equally into 3 groups. Group Ι (healthy subjects). Group ΙΙ were received low daily oral dose of VD(1000 IU) for 4 weeks. Group ΙΙΙ were received high daily oral dose of VD(4000 IU) for 4 weeks.Each group ΙΙ and ΙΙΙ divided into 2 subgroups; group b: patients with NP before taking VD and group a: patients with NP after taking. Nasal biopsies were obtained of all groups for histological examination and immunohistochemical detection of Toll-like receptors 9 expression. Results: patients of nasal polyps before VD taking (groups IIb and IIIb) presented with symptoms of Visual Analogue Scale, VAS score (facial pain, headache, nasal blockage, nasal discharge, post-nasal drip and olfactory disturbance) and endoscopic appearance of Lund and Mackey score (polypi, edema and discharge), damage of respiratory epithelium, extensive accumulation of collagen fibers in lamina propria and highly expressed TLR-9. The high dose VD group (IIIa) showed near normal respiratory epithelium, significant decrease (P<0.05) in all symptoms of VAS score, endoscopic appearance of Lund and Mackey score. The mean area % of submucosal accumulation of collagen fibers and TLR-9 expression were also significant decreased but decrease was insignificant (P<0.05) in the low dose VD group (IIa). Conclusion: VD participate significantly in protection against human nasal polyposis when used by high therapeutic dose, by reducing the size of nasal polyps, relieving the symptoms and signs of nasal polyposis.

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Fortification of orange juice with vitamin D2 or vitamin D3 is as effective as an oral supplement in maintaining vitamin D status in adults

Abstract: Vitamin D(2) and vitamin D(3) are equally bioavailable in orange juice and capsules.

Cited by 160 publications

References 45 publications

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

Comparison of vitamin D2 and vitamin D3 supplementation in raising serum 25-hydroxyvitamin D status: a systematic review and meta-analysis

Bioavailability of vitamin D2 from UV-B-irradiated button mushrooms in healthy adults deficient in serum 25-hydroxyvitamin D: a randomized controlled trial

Does vitamin D have protective effect on human nasal polyposis: histological and immunohistochemical study

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