Fortgeschrittenes Magenkarzinom

Abstract

Radical tumor resection with palliative intentions (if possible from a technical point of view) resulted in a prolongation of the median survival time of 3 months with an acceptable postoperative morbidity and mortality compared with non-resection procedures. According to the results of individual analysis of each tumor resection intervention, palliative gastrectomy showed a significant prolongation of survival time of 5 months compared with more limited subtotal resection (6 versus 11 months).

The Role of Non-Curative Surgery in Incurable, Asymptomatic Advanced Gastric Cancer

“…This subset of stage 3 patients initially were to have curative-intent surgery, however had non-curative resection with macroscopically positive margin determined intra-operatively, which got a median OS of 33.13 months. Previous literature showed most favorable OS for these initially curative intent patients (median OS 7 to 33.9 months) and supported gastrectomy for local advanced gastric cancer [10], [12], [34]–[37], in accord to our finding.…”

“…The non-curative surgery with the intent of symptom palliation, which usually included resectional surgery and non-resectional surgery such as surgical bypass, achieved a narrow range of median OS from 3 to 13 months [18], [29]–[32]. Evidence showed the significantly superior survival prognosis of the non-palliative, non-curative resection than palliative, non-curative resection [12] and palliative bypass [33], [34]. In comparison to many studies with mixed intents, one important reason for this long median OS (28 months) of non-curative surgery group is that we centered on non-palliative, non-curative resections for asymptomatic patients in most recent years.…”