Förster resonance energy transfer (FRET) paired carbon dot-based complex nanoprobes: versatile platforms for sensing and imaging applications

Miao, Shihai; Liang, Kang; Kong, Biao

doi:10.1039/c9qm00538b

Cited by 68 publications

(38 citation statements)

References 109 publications

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“…Carbon dots (CDs) are an emerging class of carbon-based nanomaterials that exhibit high intrinsic fluorescence brightness and low toxicity [ 20 ]. At present, CDs have been successfully utilized as nanoprobes [ 21 ] and drug delivery vehicles [ 22 ], as well as in bioimaging [ 23 ] and optoelectronic conversion [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

A highly sensitive dual-read assay using nitrogen-doped carbon dots for the quantitation of uric acid in human serum and urine samples

Rui

Yan

et al. 2021

Microchim Acta

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Graphical abstract A simple dual-read assay for uric acid (UA) was developed based on a combined ratiometric fluorescent and colorimetric strategy using nitrogen-doped carbon dots (N-CDs). The biosensor relies on the oxidation of UA by uricase to produce H 2 O 2 , which was then converted to • OH radicals by I - , resulting in the oxidation of o -phenylenediamine (OPD) to 2,3-diaminophenazine (DAP). In the presence of UA, the colorless biosensor system changed to yellow. Furthermore, the presence of DAP quenched the fluorescence emission of the N-CDs at 427 nm based on the inner filter effect (IFE). With increasing UA concentrations, the fluorescence intensity of the biosensor at 427 nm decreased but increased at 580 nm, demonstrating the ratiometric response. A strong linearity was observed between the fluorescence intensity ratio of DAP to N-CDs ( I 580 / I 427 ) and the corresponding UA concentration over the range 0.5−150 μM, and a limit of detection (S/N ratio of 3) of 0.06 μM was calculated. The dual-read assay was successfully employed in the quantitation of UA in human serum and urine samples, revealing its potential for measuring UA in clinical samples. Supplementary Information The online version contains supplementary material available at 10.1007/s00604-021-04971-2.

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Section: Introductionmentioning

confidence: 99%

A highly sensitive dual-read assay using nitrogen-doped carbon dots for the quantitation of uric acid in human serum and urine samples

Rui

Yan

et al. 2021

Microchim Acta

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“…There is no doubt that C-dots are a highly promising class of nanomaterials with distinct advantages with respect to conventional organic fluorescent dyes because of their multicolour nature and enhanced structural stability, while they are superior in terms of environmental friendliness and preparation ease compared to heavy metal-based quantum dots. These nanoemitters can be used in isolation for a variety of applications [ 38 ] or can be combined with other materials to generate advanced nanocomposites and devices, such as polymeric hybrids [ 27 ], powder compositions [ 87 ], ordered mesoporous frameworks [ 88 ] and C-dot-based Forster resonance energy transfer systems [ 89 ]. At the same time, their photoluminescence mechanism is not fully understood, and more studies are needed in order to gain further insights on the structure–properties relationships of those complex systems.…”

Section: Discussionmentioning

confidence: 99%

Towards Red Emissive Systems Based on Carbon Dots

Gavalas

Kelarakis

2021

Nanomaterials

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Carbon dots (C-dots) represent an emerging class of nontoxic nanoemitters that show excitation wavelength-dependent photoluminescence (PL) with high quantum yield (QY) and minimal photobleaching. The vast majority of studies focus on C-dots that exhibit the strongest PL emissions in the blue/green region of the spectrum, while longer wavelength emissions are ideal for applications such as bioimaging, photothermal and photodynamic therapy and light-emitting diodes. Effective strategies to modulate the PL emission of C-dot-based systems towards the red end of the spectrum rely on extensive conjugation of sp2 domains, heteroatom doping, solvatochromism, surface functionalization and passivation. Those approaches are systematically presented in this review, while emphasis is given on important applications of red-emissive suspensions, nanopowders and polymer nanocomposites.

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“…The mechanism of static quenching could be explained as that which occurs when a non-fluorescent groundstate complex is formed due to the interaction of the quencher and CQDs, while the dynamic quenching mechanism could occur by the return of the excited states to the ground state as a consequence of the CQDs and quencher collision due to the charge or energy transfer [82,83]. The FRET mechanism includes the transfer of non-radiative energy between a luminescent donor (first fluorophore; CQDs) and an energy acceptor (second fluorophore; quencher) within a close range of approximately 10 to 100 Å [83,84]. The FRET mechanism occurs between CQDs in the excited state and a quencher in the ground state, and the emission spectrum of CQDs overlaps with the absorption spectrum of the quencher.…”

Section: Sensing Mechanismsmentioning

confidence: 99%

An Overview of the Recent Developments in Carbon Quantum Dots—Promising Nanomaterials for Metal Ion Detection and (Bio)Molecule Sensing

et al. 2021

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The fluorescent carbon quantum dots (CQDs) represent an emerging subset of carbonaceous nanomaterials, recently becoming a powerful tool for biosensing, bioimaging, and drug and gene delivery. In general, carbon dots are defined as zero-dimensional (0D), spherical-like nanoparticles with <10 nm in size. Their unique chemical, optical, and electronic properties make CQDs versatile materials for a wide spectrum of applications, mainly for the sensing and biomedical purposes. Due to their good biocompatibility, water solubility, and relatively facile modification, these novel materials have attracted tremendous interest in recent years, which is especially important for nanotechnology and nanoscience expertise. The preparation of the biomass-derived CQDs has attracted growing interest recently due to their low-cost, renewable, and green biomass resources, presenting also the variability of possible modification for the enhancement of CQDs’ properties. This review is primarily focused on the recent developments in carbon dots and their application in the sensing of different chemical species within the last five years. Furthermore, special emphasis has been made regarding the green approaches for obtaining CQDs and nanomaterial characterization toward better understanding the mechanisms of photoluminescent behavior and sensing performance. In addition, some of the challenges and future outlooks in CQDs research have been briefly outlined.

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Förster resonance energy transfer (FRET) paired carbon dot-based complex nanoprobes: versatile platforms for sensing and imaging applications

Abstract: Förster resonance energy transfer (FRET) paired carbon dot composite nanoprobes are studied as multi-functional platforms for sensing and imaging applications.

Cited by 68 publications

References 109 publications

A highly sensitive dual-read assay using nitrogen-doped carbon dots for the quantitation of uric acid in human serum and urine samples

A highly sensitive dual-read assay using nitrogen-doped carbon dots for the quantitation of uric acid in human serum and urine samples

Towards Red Emissive Systems Based on Carbon Dots

An Overview of the Recent Developments in Carbon Quantum Dots—Promising Nanomaterials for Metal Ion Detection and (Bio)Molecule Sensing

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