Forskolin-driven conversion of human somatic cells into induced neurons through regulation of the cAMP-CREB1-JNK signaling
Guodong Wang,
Dandan Zhang,
Liangshan Qin
et al.
Abstract:Human somatic cells can be reprogrammed into neuron cell fate through regulation of a single transcription factor or application of small molecule cocktails.
Methods:
Here, we report that forskolin efficiently induces the conversion of human somatic cells into induced neurons (FiNs).
Results:
A large population of neuron-like phenotype cells was observed as early as 24-36 h post-induction. There were >90% TUJ1-, >80% MAP2-, and >80% NEUN-positive neurons at 5 day… Show more
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