Formyl Peptide Receptor 2 Is Involved in Cardiac Repair After Myocardial Infarction Through Mobilization of Circulating Angiogenic Cells

Heo, Soon Chul; Kwon, Yang Woo; Jang, Il Ho; Jeong, Geun Ok; Lee, Tae Wook; Yoon, Jaesik; Shin, Ho Jin; Jeong, Hae Chang; Ahn, Young Keun; Ko, Tae Hee; Lee, Sang Chul; Han, Jin; Kim, Jae Ho

doi:10.1002/stem.2535

Cited by 32 publications

(34 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We recently reported the activation of formyl peptide receptor 2 led to the mobilization of Flk‐1 + /Sca‐1 + CACs from bone marrow and to subsequent repair of infarcted myocardium. Furthermore, Flk‐1 + /Sca‐1 + cells isolated from bone marrow of wild‐type mice were found to recapitulate the therapeutic effects of formyl peptide receptor activation . These reports support our finding that Ac‐PGP accelerates the mobilization of Flk‐1 + /Sca‐1 + CACs, and thus, neovascularization in ischemic tissues.…”

Section: Discussionsupporting

confidence: 88%

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications

Kwon

Lee

Heo

et al. 2018

Stem Cells Translational Medicine

Self Cite

View full text Add to dashboard Cite

Circulating angiogenic cells (CACs) have been implicated in the repair of ischemic tissues, and their mobilization from bone marrow is known to be regulated by the activations of chemokine receptors, including CXCR2 and CXCR4. This study was conducted to investigate the role of N‐acetylated proline‐glycine‐proline (Ac‐PGP; a collagen‐derived chemotactic tripeptide) on CAC mobilization and its therapeutic potential for the treatment of peripheral artery diseases. Ac‐PGP was administered daily to a murine hind limb ischemia model, and the effects of Ac‐PGP on blood perfusion and CAC mobilization (Sca1+Flk1+ cells) into peripheral blood were assessed. Intramuscular administration of Ac‐PGP significantly improved ischemic limb perfusion and increased limb salvage rate by increasing blood vessel formation, whereas Ac‐PGP‐induced blood perfusion and angiogenesis in ischemic limbs were not observed in CXCR2‐knockout mice. In addition, Ac‐PGP‐induced CAC mobilization was found to occur in wild‐type mice but not in CXCR2‐knockout mice. Transplantation of bone marrow from green fluorescent protein (GFP) transgenic mice to wild‐type mice showed bone marrow‐derived cells homed to ischemic limbs after Ac‐PGP administration and that GFP‐positive cells contributed to the formation of ILB4‐positive capillaries and α smooth muscle actin (α‐SMA)‐positive arteries. These results suggest CXCR2 activation in bone marrow after Ac‐PGP administration improves blood perfusion and reduces tissue necrosis by inducing CAC mobilization. These findings suggest a new pharmaceutical basis for the treatment of critical limb ischemia. Stem Cells Translational Medicine 2019;8:236&246

show abstract

Section: Discussionsupporting

confidence: 88%

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications

Kwon

Lee

Heo

et al. 2018

Stem Cells Translational Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…[ 38 ] In addition, activation of FPR2 , the family member of FPR1 , is involved in cardiac repair after MI via mobilization of circulating angiogenic cells. [ 39 ] Therefore, the deregulated expression of FPRs might account for the occurrence of AMI. In our study, FPR1 was predicted as a crucial node in the PPI network.…”

Section: Discussionmentioning

confidence: 99%

Biomarkers identification for acute myocardial infarction detection via weighted gene co-expression network analysis

Zhang¹,

Liu²,

Liu³

et al. 2017

Medicine

View full text Add to dashboard Cite

The study aimed to seek potential biomarkers for acute myocardial infarction (AMI) detection and treatment.The dataset GSE48060 was used, consisting of 52 peripheral blood samples (31 AMI samples and 21 normal controls). By limma package, differentially expressed genes (DEGs) between 2 kinds of samples were identified, followed by enrichment analysis, subpathway analysis, protein–protein interaction (PPI) network analysis, and transcription factor network (TFN) analysis. Weighted gene co-expression network analysis was used to further extract key modules relating to AMI, followed by enrichment and TFN analyses. Expression validation was performed via meta-analysis of 2 datasets, GSE22229 and GSE29111.A set of 428 DEGs in AMI were screened out, and the upregulated toll-like receptor (TLR) family genes (TLR1, TLR2, and TLR10) were enriched in wound response, immune response and inflammatory response functions, and downregulated genes (GBP5, CXCL5, GZMA, CCL5, and CCL4) were correlated with immune response. CCL5, GZMA, GZMB, TLR2, and formyl peptide receptor 1 (FPR1) were predicted as crucial nodes in the PPI network. Signal transducer and activator of transcription 1 (STAT1) was the key transcription factor (TF) with multiple targets. The grey module was highly related to AMI. Genes in this module were closely related to regulation of macrophage activation, and spermatogenic leucine zipper 1 (SPZ1) was identified as a TF. Expressions of TLR2 and FPR1 were confirmed via the integrated matrix.Several potential biomarkers for AMI detection were identified, such as GZMB, GBP5, FPR1, TLR2, STAT1, and SPZ1. They might exert their functions via regulation of immune and inflammation responses. Genes in grey module play significant roles in AMI via regulation of macrophage activation.

show abstract

“…For instance, its activation by the WKYMVm peptide stimulated chemotactic migration, angiogenesis, and proliferation ability of human endothelial colony forming cells, thus promoting ischemic limb salvage . Moreover, FPR2‐dependent mobilization of circulating angiogenic cells contributed to myocardial protection and neovascularization in a murine model of myocardial infarction .…”

Section: Spm Receptors and Scsmentioning

confidence: 99%

Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review

Romano

Patruno

Pomilio

et al. 2019

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Summary Accumulating evidence indicates that stem cells (SCs) possess immunomodulatory, anti‐inflammatory, and prohealing properties. The mechanisms underlying these functions are being investigated with the final goal to set a solid background for the clinical use of SCs and/or their derivatives. Specialized proresolving lipid mediators (SPMs) are small lipids formed by the enzymatic metabolism of polyunsaturated fatty acids. They represent a leading class of molecules that actively and timely regulate the resolution of inflammation and promote tissue/organ repair. SC formation of these mediators as well as expression of their receptors has been recently reported, suggesting that SPMs may be involved in the immunomodulatory, proresolving functions of SCs. In the present review, we summarize the current knowledge on SPMs in SCs, focusing on biosynthetic pathways, receptors, and bioactions, with the intent to provide an integrated view of SPM impact on SC biology. Stem Cells Translational Medicine 2019;8:992–998

show abstract

Formyl Peptide Receptor 2 Is Involved in Cardiac Repair After Myocardial Infarction Through Mobilization of Circulating Angiogenic Cells

Cited by 32 publications

References 47 publications

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications

Role of CXCR2 in the Ac-PGP-Induced Mobilization of Circulating Angiogenic Cells and its Therapeutic Implications

Biomarkers identification for acute myocardial infarction detection via weighted gene co-expression network analysis

Proresolving Lipid Mediators and Receptors in Stem Cell Biology: Concise Review

Contact Info

Product

Resources

About