Formyl MIDA Boronate: C₁ Building Block Enables Straightforward Access to α‐Functionalized Organoboron Derivatives

Abstract

Formyl MIDA boronate has been known to be an elusive type of acylboronate that has not been obtained to date. In this work, an approach to the one‐pot preparation and chemical transformations of formyl MIDA boronate were developed to provide new types of α‐functionalized organoboron compounds. Among them are acylboronate reagents which present boron‐substituted analogues of ynones and β‐dicarbonyl compounds. The developed synthetic procedures, utilizing formyl MIDA boronate, are tolerant to diverse functional groups, making this reagent an advantageous C1 building block for extending the scope of organoboron chemistry.

Synthesis of Acylboron Compounds

“…Note added in proof: Since the submission of this Minireview,G rygorenko and co-workers reported the synthesis of formyl MIDAb oronate.T reatment of this building Angewandte block with organotitanium reagents followed by Dess Martin/ Swern oxidation produced alkynyl acylboronates. [63]…”

“…Minireviews block with organotitanium reagents followed by Dess Martin/ Swern oxidation produced alkynyl acylboronates. [63]…”

Synthesis of Acylboron Compounds

“…Kurzaufsätze block with organotitanium reagents followed by Dess Martin/ Swern oxidation produced alkynyl acylboronates. [63]…”