Formulation technologies for oral vaccines

New, R. R. C.

doi:10.1111/cei.13352

Cited by 24 publications

(15 citation statements)

References 153 publications

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“…With subunit and recombinant vaccines, protection of the antigen from the harsh stomach environment will need to be addressed, and formulations can be tailored to the target species. [116][117][118][119][120] With distribution in the wild, vaccine formulations will need to be protected from environmental factors such as rain and sunshine.…”

Section: Development Of Reservoir-targeted Vaccinesmentioning

confidence: 99%

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Anti‐tick and pathogen transmission blocking vaccines

Oosterwijk

2021

Parasite Immunology

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Ticks and tick-borne diseases are a challenge for medical and veterinary public health and often controlled through the use of repellents and acaricides. Research on vaccination strategies to protect humans, companion animals, and livestock from ticks and tick-transmitted pathogens has accelerated through the use of proteomic and transcriptomic analyses. Comparative analyses of unfed versus engorged and uninfected versus infected ticks have provided valuable insights into candidates for antitick and pathogen transmission blocking vaccines. An intricate interplay between tick saliva and the host's immune system has revealed potential antigens to be used in vaccination strategies. Immunization of hosts with targeted anti-tick vaccines would ideally lead to a reduction in tick numbers and prevent transmission of tick-borne pathogens. Comprehensive control of tick-borne diseases would come from successful anti-tick vaccination, vaccination preventing transmission of tick-borne diseases or a combination. Due to the close interaction with wildlife and ticks, with wildlife reservoirs enabling propagation of pathogens between ticks, the vaccination of these reservoirs is an attractive target to reduce human contact with ticks and tick-borne diseases through a one-health approach. Wildlife vaccination presents formulation and regulatory challenges which should be considered early in the development of reservoir-targeted vaccines.

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Section: Development Of Reservoir-targeted Vaccinesmentioning

confidence: 99%

“…Formulations can be tailored to aid in oral delivery and immune stimulation. With subunit and recombinant vaccines, protection of the antigen from the harsh stomach environment will need to be addressed, and formulations can be tailored to the target species 116‐120 …”

Section: Reservoir‐targeted Vaccinesmentioning

confidence: 99%

Anti‐tick and pathogen transmission blocking vaccines

Oosterwijk

2021

Parasite Immunology

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“…Drugs in general are absorbed faster and access directly the blood circulation bypassing the liver; therefore, avoiding hepatic clearance [ 209 ]. The convenience of oral formulation has led to significant efforts in the formulation of oral vaccines [ 210 , 211 , 212 , 213 ]; however, oral mucosa delivery is not generally considered for conventional vaccines due to a limited accessibility and its low immunogenic potential.…”

Section: Potential Of Oral Mucosa Characterization In Diagnosis and Treatmentmentioning

confidence: 99%

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Gómez‐Casado

Sánchez-Solares

Izquierdo

et al. 2021

Foods

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Most prevalent food allergies during early childhood are caused by foods with a high allergenic protein content, such as milk, egg, nuts, or fish. In older subjects, some respiratory allergies progressively lead to food-induced allergic reactions, which can be severe, such as urticaria or asthma. Oral mucosa remodeling has been recently proven to be a feature of severe allergic phenotypes and autoimmune diseases. This remodeling process includes epithelial barrier disruption and the release of inflammatory signals. Although little is known about the immune processes taking place in the oral mucosa, there are a few reports describing the oral mucosa-associated immune system. In this review, we will provide an overview of the recent knowledge about the role of the oral mucosa in food-induced allergic reactions, as well as in severe respiratory allergies or food-induced autoimmune diseases, such as celiac disease.

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“…Other parts of the intestine also play a role, particularly the lamina propria, a compartment stretching the length of the intestine basal to the enterocytes, feeding into the intestinal lymphatics, and a population of intra-epithelial lymphocytes (IEL) embedded within the tight junctions of the much larger epithelial cells. For a general review of formulations for oral vaccines, see New [ 4 ].…”

Section: Architecture Of the Intestinal Tractmentioning

confidence: 99%

Oral Delivery of Biologics via the Intestine

New

2020

Pharmaceutics

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Biologics are currently one of the most promising avenues for therapeutic interventions in conditions such as metabolic disease, ageing and inflammatory disorders, and for chronic ailments, oral delivery of such medicines has for years been recognised as an important goal. Despite decades of intensive research, oral delivery of biologics is only just starting to prove feasible. There has been much talk about the barriers to uptake of biologics, and indeed, one function of the intestine is to prevent, in one way or another, passage of unwanted materials across the gut, and yet, grams of biological agents both large and small pass across the intestinal cell wall every day. This review first describes the functioning of the gut under normal circumstances, then identifies the principle biological mechanisms which have been harnessed successfully, to date, to achieve oral uptake, outlining the pros and cons of each approach. Examples with different biologics are given, and information on result of the latest clinical trials is provided, where available.

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Formulation technologies for oral vaccines

Cited by 24 publications

References 153 publications

Anti‐tick and pathogen transmission blocking vaccines

Anti‐tick and pathogen transmission blocking vaccines

Oral Mucosa as a Potential Site for Diagnosis and Treatment of Allergic and Autoimmune Diseases

Oral Delivery of Biologics via the Intestine

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